Slco1a1 solute carrier organic anion transporter family, member 1a1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slco1a1provided by MGI
Official Full Name: solute carrier organic anion transporter family, member 1a1provided by MGI
Primary source: MGI:MGI:1351891
See related: Ensembl:ENSMUSG00000041698 AllianceGenome:MGI:1351891
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Oatp1; OATP-1; Oatp1a1; Slc21a1; A530084B21
Summary: Enables organic anion transmembrane transporter activity. Acts upstream of or within organic anion transport and response to stilbenoid. Located in basolateral plasma membrane. Is integral component of plasma membrane. Is expressed in brain ventricular layer; metanephros; submandibular gland primordium; and thymus primordium. Orthologous to human SLCO1A2 (solute carrier organic anion transporter family member 1A2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver adult (RPKM 3.1) and liver E18 (RPKM 0.2) See more
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Genomic context

Location:: 6 G2; 6 73.09 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (141853007..141892688, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (141907281..141946962, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Organic anion-transporting polypeptides exert strong impact on disposition and toxicity of antitumor drugs. (Review)
Title: The impact of Organic Anion-Transporting Polypeptides (OATPs) on disposition and toxicity of antitumor drugs: Insights from knockout and humanized mice.
important roles for OATP1A/1B in transporter-mediated uptake and disposition of doxorubicin, are reported.
Title: Contribution of Organic Anion-Transporting Polypeptides 1A/1B to Doxorubicin Uptake and Clearance.
Data indicate that organic anion-transporting polypeptides Oatp1a/1b-null mice had increased levels of carboxylesterase (Ces) enzymes, which caused higher conversion of irinotecan to SN-38 in plasma, potentially complicating pharmacokinetic analyses.
Title: OATP1A/1B transporters affect irinotecan and SN-38 pharmacokinetics and carboxylesterase expression in knockout and humanized transgenic mice.
PDZK1 regulates intracellular trafficking of Oatp1a1.
Title: Oatp1a1 requires PDZK1 to traffic to the plasma membrane by selective recruitment of microtubule-based motor proteins.
Loss of Oatp1a1 function exacerbates cholestatic liver injury in mice and suggest that Oatp1a1 plays a unique role in liver adaptive responses to obstructive cholestasis.
Title: Organic anion transporting polypeptide 1a1 null mice are sensitive to cholestatic liver injury.
Dysfunction of organic anion transporting polypeptide 1a1 alters intestinal bacteria and bile acid metabolism.
Title: Dysfunction of organic anion transporting polypeptide 1a1 alters intestinal bacteria and bile acid metabolism in mice.
Oatp1a1 is more highly expressed in males than in females. Null mice showed inhibited hepatocyte transporter functions and an altered urinary metabolome.
Title: Characterization of organic anion-transporting polypeptide (Oatp) 1a1 and 1a4 null mice reveals altered transport function and urinary metabolomic profiles.
Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs.
Title: Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs.
Report critical role of PPAR-alpha in perfluorooctanoic acid- and perfluorodecanoic acid-induced downregulation of Oatp1a1 uptake transporter in mouse liver.
Title: Critical role of PPAR-alpha in perfluorooctanoic acid- and perfluorodecanoic acid-induced downregulation of Oatp uptake transporters in mouse livers.
organic anion transporting polypeptide-1 (Oatp1) were down-regulated by taurocholate and not affected by cholestyramine feeding
Title: Effects of bile salt flux variations on the expression of hepatic bile salt transporters in vivo in mice.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

D6Mit136 (e-PCR), detects polymorphism
- UniSTS:130680

Slco1a1 (e-PCR), detects polymorphism
- UniSTS:546032

AI790453 (e-PCR)
- UniSTS:164342

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables bile acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables organic anion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables organic anion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables sodium-independent organic anion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in bile acid and bile salt transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within organic anion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in response to stilbenoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in sodium-independent organic anion transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within transmembrane transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: solute carrier organic anion transporter family member 1A1

Names: sodium-independent organic anion-transporting polypeptide 1; solute carrier family 21 (organic anion transporter), member 1; solute carrier family 21 member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013797.5 → NP_038825.1 solute carrier organic anion transporter family member 1A1

See identical proteins and their annotated locations for NP_038825.1

Status: VALIDATED

Source sequence(s)

AC156277, AF223067, BB848260

Consensus CDS

CCDS39691.1

UniProtKB/Swiss-Prot

Q9QXZ6

UniProtKB/TrEMBL

Q53ZW9, Q7TQB3

Related

ENSMUSP00000037022.6, ENSMUST00000042119.6

Conserved Domains (3) summary

cd06174
Location:23 → 396

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

cd01330
Location:436 → 488

KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...

TIGR00805
Location:1 → 625

oat; sodium-independent organic anion transporter