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    Utp4 UTP4 small subunit processome component [ Mus musculus (house mouse) ]

    Gene ID: 21771, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Utp4provided by MGI
    Official Full Name
    UTP4 small subunit processome componentprovided by MGI
    Primary source
    MGI:MGI:1096573
    See related
    Ensembl:ENSMUSG00000041438 AllianceGenome:MGI:1096573
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Naic; Cirh1a; Cirhin; Tex292; Teg-292
    Summary
    Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and regulation of transcription, DNA-templated. Predicted to act upstream of or within rRNA processing. Predicted to be located in chromosome and fibrillar center. Predicted to be part of 90S preribosome; small-subunit processome; and t-UTP complex. Is expressed in peripheral nervous system ganglion; renal cortex; telencephalon ventricular layer; and thymus primordium. Human ortholog(s) of this gene implicated in cholestasis and primary biliary cholangitis. Orthologous to human UTP4 (UTP4 small subunit processome component). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver E14.5 (RPKM 18.0), liver E14 (RPKM 17.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Utp4 in Genome Data Viewer
    Location:
    8 D3; 8 53.32 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (107620272..107649726)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (106893640..106923094)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_22582 Neighboring gene predicted gene, 53451 Neighboring gene hyaluronan synthase 3 Neighboring gene ES cell cis-regulatory motif 8a Neighboring gene CTF8, chromosome transmission fidelity factor 8 Neighboring gene DERPC proline and glycine rich nuclear protein Neighboring gene STARR-seq mESC enhancer starr_22583 Neighboring gene ribosomal protein L10, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_22588 Neighboring gene syntrophin, basic 2 Neighboring gene STARR-seq mESC enhancer starr_22589 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:109526496-109526679 Neighboring gene predicted gene, 22085

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Tex261, a novel gene presumably related but distinct from steroidogenic acute regulatory (StAR) gene, is regulated during the development of germ cells. López-Fernández LA, et al. Biochem Biophys Res Commun, 1998 Jan 26. PMID 9464256
    2. Characterization of genes expressed early in mouse spermatogenesis, isolated from a subtractive cDNA library. López-Fernández LA, et al. Mamm Genome, 1996 Sep. PMID 8703127
    3. A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis. Chagnon P, et al. Am J Hum Genet, 2002 Dec. PMID 12417987, Free PMC Article
    4. Development of an efficient screening system to identify novel bone metabolism-related genes using the exchangeable gene trap mutagenesis mouse models. Kurogi S, et al. Sci Rep, 2017 Jan 20. PMID 28106071, Free PMC Article
    5. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in maturation of SSU-rRNA ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosomal small subunit biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of 90S preribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of small-subunit processome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of t-UTP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of t-UTP complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    U3 small nucleolar RNA-associated protein 4 homolog
    Names
    cirrhosis, autosomal recessive 1A
    testis-expressed gene 292 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358982.1 → NP_001345911.1  U3 small nucleolar RNA-associated protein 4 homolog

      Status: VALIDATED

      Source sequence(s)
      AC123864
      Consensus CDS
      CCDS52664.1
      UniProtKB/Swiss-Prot
      Q62306, Q62307, Q69Z48, Q6NVG9, Q8R2N2, Q8VEL5
      UniProtKB/TrEMBL
      Q3UJY3
      Conserved Domains (2) summary
      sd00039
      Location:21 → 57
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:16 → 306
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_011574.2 → NP_035704.2  U3 small nucleolar RNA-associated protein 4 homolog

      See identical proteins and their annotated locations for NP_035704.2

      Status: VALIDATED

      Source sequence(s)
      BC068113, CN718589, DV658234
      Consensus CDS
      CCDS52664.1
      UniProtKB/Swiss-Prot
      Q62306, Q62307, Q69Z48, Q6NVG9, Q8R2N2, Q8VEL5
      UniProtKB/TrEMBL
      Q3UJY3
      Related
      ENSMUSP00000048377.6, ENSMUST00000047629.7
      Conserved Domains (2) summary
      sd00039
      Location:21 → 57
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:16 → 306
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      107620272..107649726
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R2N2.3 GenPept UniProtKB/Swiss-Prot:Q8R2N2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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