Tcl1 T cell lymphoma breakpoint 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tcl1provided by MGI
Official Full Name: T cell lymphoma breakpoint 1provided by MGI
Primary source: MGI:MGI:1097166
See related: Ensembl:ENSMUSG00000041359 AllianceGenome:MGI:1097166
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tcl1a
Summary: Predicted to enable identical protein binding activity; protein kinase binding activity; and protein serine/threonine kinase activator activity. Involved in activation of protein kinase B activity. Acts upstream of or within negative regulation of gene expression; regulation of stem cell population maintenance; and stem cell population maintenance. Located in cell cortex and pronucleus. Is expressed in several structures, including early conceptus; hemolymphoid system gland; liver; and seminiferous cord. Orthologous to human TCL1A (TCL1 family AKT coactivator A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward ovary adult (RPKM 9.8) See more
Orthologs: human all
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Genomic context

Location:: 12 E; 12 55.28 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (105183012..105188996, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (105216753..105222737, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Oncogenic role and target properties of the lysine-specific demethylase KDM1A in chronic lymphocytic leukemia.
Title: Oncogenic role and target properties of the lysine-specific demethylase KDM1A in chronic lymphocytic leukemia.
Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis.
Title: Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis.
The proto-oncogene TCL1A deregulates cell cycle and genomic stability in CLL.
Title: The proto-oncogene TCL1A deregulates cell cycle and genomic stability in CLL.
Evidence for Non-Cancer-Specific T Cell Exhaustion in the Tcl1 Mouse Model for Chronic Lymphocytic Leukemia.
Title: Evidence for Non-Cancer-Specific T Cell Exhaustion in the Tcl1 Mouse Model for Chronic Lymphocytic Leukemia.
Protein kinase Akt2/PKBbeta is involved in blastomere proliferation of preimplantation mouse embryos.
Title: Protein kinase Akt2/PKBβ is involved in blastomere proliferation of preimplantation mouse embryos.
TCL1 transgenic mice as a model for CD49d-high chronic lymphocytic leukemia.
Title: TCL1 transgenic mice as a model for CD49d-high chronic lymphocytic leukemia.
acalabrutinib showed increased BTK selectivity compared with ibrutinib while demonstrating significant antitumor efficacy in vivo on par with ibrutinib. Similarly, in the TCL1 adoptive transfer model, decreased phosphorylation of BTK, PLCgamma2, and S6 was observed. Most notably, treatment with acalabrutinib resulted in a significant increase in survival compared with mice receiving vehicle
Title: The Bruton Tyrosine Kinase (BTK) Inhibitor Acalabrutinib Demonstrates Potent On-Target Effects and Efficacy in Two Mouse Models of Chronic Lymphocytic Leukemia.
suggests that in the TCL1-tg mouse, main tumor support may not be derived from CD4+ T cells, but from the monocytic population
Title: CD4+ T cells, but not non-classical monocytes, are dispensable for the development of chronic lymphocytic leukemia in the TCL1-tg murine model.
we revealed that one of the key functions of KLF4-induced TCL1 during reprogramming is to promote the metabolic shift from oxidative phosphorylation to glycolysis.
Title: A Role for KLF4 in Promoting the Metabolic Shift via TCL1 during Induced Pluripotent Stem Cell Generation.
results indicate that decreased Cav-1 in Emu-TCL1 mice significantly delays the onset of CLL and decreases leukemic progression by inhibiting MAPK-Erk signaling, suggesting a role for Cav-1 in the proliferation and progression of CLL
Title: Absence of caveolin-1 leads to delayed development of chronic lymphocytic leukemia in Eμ-TCL1 mouse model.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Tcl1 (e-PCR), detects polymorphism
- UniSTS:257029

PMC24451P1 (e-PCR)
- UniSTS:272256

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in activation of protein kinase B activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of stem cell population maintenance	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within somatic stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in ooplasm	IDA Inferred from Direct Assay more info	PubMed
located_in pronucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: T-cell leukemia/lymphoma protein 1A

Names: TCL-1; oncogene TCL-1; oncogene TCL1; protein p14 TCL1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001289468.1 → NP_001276397.1 T-cell leukemia/lymphoma protein 1A isoform 2

See identical proteins and their annotated locations for NP_001276397.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) has a longer and distinct C-terminus.

Source sequence(s)

AK149361, DV653827, DV660020

Consensus CDS

CCDS70418.1

UniProtKB/TrEMBL

Q3UES7

Related

ENSMUSP00000098632.4, ENSMUST00000101071.4

Conserved Domains (1) summary

pfam01840
Location:1 → 98

TCL1_MTCP1; TCL1/MTCP1 family
NM_001309484.1 → NP_001296413.1 T-cell leukemia/lymphoma protein 1A isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks an alternate internal exon and contains an alternate internal exon, resulting in the use of an alternate start codon, compared to variant 2. The encoded isoform (3) has a shorter and distinct N-terminus, compared to isoform 2.

Source sequence(s)

CJ087217, DV646075, DV649899, DV653827, DV660020
NM_001309485.1 → NP_001296414.1 T-cell leukemia/lymphoma protein 1A isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses an alternate splice site in its 3' coding region and contains an alternate internal exon, resulting in a frameshift and an early stop codon, compared to variant 2. The encoded isoform (4) has a shorter and distinct C-terminus, compared to isoform 2.

Source sequence(s)

CA558861, DV646075, DV653827, DV655843, DV660020

Consensus CDS

CCDS83999.1

UniProtKB/TrEMBL

H3BJP6

Related

ENSMUSP00000135069.2, ENSMUST00000176579.2

Conserved Domains (1) summary

pfam01840
Location:1 → 80

TCL1_MTCP1; TCL1/MTCP1 family
NM_009337.3 → NP_033363.1 T-cell leukemia/lymphoma protein 1A isoform 1

See identical proteins and their annotated locations for NP_033363.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes isoform 1.

Source sequence(s)

AK163387, BC052336, DV653827

Consensus CDS

CCDS36549.1

UniProtKB/Swiss-Prot

P56280

UniProtKB/TrEMBL

H3BJA0

Related

ENSMUSP00000036066.9, ENSMUST00000041316.15

Conserved Domains (1) summary

pfam01840
Location:1 → 110

TCL1_MTCP1; TCL1/MTCP1 family

RNA

NR_110339.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

CJ087554, DV648028, DV653827, DV660020, DV663230