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    Atg2b autophagy related 2B [ Mus musculus (house mouse) ]

    Gene ID: 76559, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Atg2bprovided by MGI
    Official Full Name
    autophagy related 2Bprovided by MGI
    Primary source
    MGI:MGI:1923809
    See related
    Ensembl:ENSMUSG00000041341 AllianceGenome:MGI:1923809
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA4067; 2410024A21Rik; C030004M05Rik; C630028L02Rik
    Summary
    Predicted to enable lipid transfer activity and phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in autophagy of mitochondrion; autophagy of nucleus; and macroautophagy. Predicted to be located in nucleoplasm. Predicted to be active in phagophore assembly site. Predicted to be extrinsic component of membrane. Orthologous to human ATG2B (autophagy related 2B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 6.2), testis adult (RPKM 5.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    12 E; 12 55.82 cM
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (105579798..105651554, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (105613539..105685297, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_33182 Neighboring gene bradykinin receptor, beta 2 Neighboring gene STARR-positive B cell enhancer ABC_E4041 Neighboring gene bradykinin receptor, beta 1 Neighboring gene STARR-seq mESC enhancer starr_33186 Neighboring gene STARR-seq mESC enhancer starr_33187 Neighboring gene STARR-positive B cell enhancer ABC_E5352 Neighboring gene GSK3B interacting protein Neighboring gene adenylate kinase 7 Neighboring gene STARR-seq mESC enhancer starr_33192 Neighboring gene STARR-seq mESC enhancer starr_33193

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Development and application of a recombination-based library versus library high- throughput yeast two-hybrid (RLL-Y2H) screening system. Yang F, et al. Nucleic Acids Res, 2018 Feb 16. PMID 29165646, Free PMC Article
    2. Mouse satellite DNA is transcribed in senescent cardiac muscle. Gaubatz JW, et al. J Biol Chem, 1990 Oct 15. PMID 1698780
    3. Loss of Atg2b and Gskip Impairs the Maintenance of the Hematopoietic Stem Cell Pool Size. Sakai SS, et al. Mol Cell Biol, 2022 Jan 20. PMID 34748402, Free PMC Article
    4. Macrophage autophagy in immunity to Cryptococcus neoformans and Candida albicans. Nicola AM, et al. Infect Immun, 2012 Sep. PMID 22710871, Free PMC Article
    5. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA4067

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lipid transfer activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-membrane adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in autophagy of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagy of peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in piecemeal microautophagy of the nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in reticulophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in phagophore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in phagophore assembly site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    autophagy-related protein 2 homolog B
    Names
    ATG2 autophagy related 2 homolog B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001403515.1 → NP_001390444.1  autophagy-related protein 2 homolog B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC068459, AC158526

    2. NM_029654.5 → NP_083930.5  autophagy-related protein 2 homolog B isoform 1

      See identical proteins and their annotated locations for NP_083930.5

      Status: VALIDATED

      Source sequence(s)
      AC068459, AC158526
      Consensus CDS
      CCDS36550.1
      UniProtKB/Swiss-Prot
      A0PJL7, Q80XK6, Q8BIQ4, Q8BIV0, Q8R1H5, Q9CWK6
      Related
      ENSMUSP00000037441.8, ENSMUST00000041055.9
      Conserved Domains (3) summary
      pfam09333
      Location:1977 → 2071
      ATG_C; Autophagy-related protein C terminal domain
      pfam12624
      Location:11 → 105
      Chorein_N; N-terminal region of Chorein or VPS13
      pfam13329
      Location:1239 → 1359
      ATG2_CAD; Autophagy-related protein 2 CAD motif

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      105579798..105651554 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157656.1 → XP_036013549.1  autophagy-related protein 2 homolog B isoform X3

      UniProtKB/TrEMBL
      A0A1Y7VNP1
      Conserved Domains (1) summary
      pfam09333
      Location:916 → 1010
      ATG_C; Autophagy-related protein C terminal domain

    2. XM_006516361.3 → XP_006516424.1  autophagy-related protein 2 homolog B isoform X2

      UniProtKB/TrEMBL
      A0A1Y7VNP1
      Related
      ENSMUSP00000152527.2, ENSMUST00000221015.2
      Conserved Domains (1) summary
      pfam09333
      Location:917 → 1011
      ATG_C; Autophagy-related protein C terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80XK6.3 GenPept UniProtKB/Swiss-Prot:Q80XK6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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