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    Il17rd interleukin 17 receptor D [ Mus musculus (house mouse) ]

    Gene ID: 171463, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Il17rdprovided by MGI
    Official Full Name
    interleukin 17 receptor Dprovided by MGI
    Primary source
    MGI:MGI:2159727
    See related
    Ensembl:ENSMUSG00000040717 AllianceGenome:MGI:2159727
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sef; mSef; Sef-S; IL-17RD; 2810004A10Rik
    Summary
    Predicted to enable interleukin-17 receptor activity. Involved in negative regulation of epithelial to mesenchymal transition and negative regulation of transforming growth factor beta receptor signaling pathway. Predicted to be located in Golgi apparatus and nucleoplasm. Is expressed in several structures, including alimentary system; brain; branchial arch; extraembryonic component; and sensory organ. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 18 with or without anosmia. Orthologous to human IL17RD (interleukin 17 receptor D). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in limb E14.5 (RPKM 5.6), lung adult (RPKM 4.4) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    14 A3; 14 16.09 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (26760990..26829243)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (27038964..27107286)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 Neighboring gene STARR-seq mESC enhancer starr_36250 Neighboring gene STARR-seq mESC enhancer starr_36251 Neighboring gene predicted gene, 41114 Neighboring gene STARR-positive B cell enhancer mm9_chr14:27843023-27843323 Neighboring gene STARR-seq mESC enhancer starr_36253 Neighboring gene homeobox gene expressed in ES cells Neighboring gene STARR-seq mESC enhancer starr_36262 Neighboring gene STARR-seq mESC enhancer starr_36263 Neighboring gene Rho guanine nucleotide exchange factor 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:28044030-28044193 Neighboring gene predicted gene 7591 Neighboring gene predicted gene, 34848

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. IL-17RD/sef exacerbates experimental mouse colitis and inflammation-associated tumorigenesis by regulating the proportion of T cell subsets. Fu Y, et al. FEBS Lett, 2022 Feb. PMID 34939667
    2. Loss of interleukin-17 receptor D promotes chronic inflammation-associated tumorigenesis. Girondel C, et al. Oncogene, 2021 Jan. PMID 33177649
    3. Sef is a negative regulator of fiber cell differentiation in the ocular lens. Newitt P, et al. Differentiation, 2010 Jul. PMID 20542628, Free PMC Article
    4. A shedding soluble form of interleukin-17 receptor D exacerbates collagen-induced arthritis through facilitating TNF-α-dependent receptor clustering. Liu S, et al. Cell Mol Immunol, 2021 Aug. PMID 32963355, Free PMC Article
    5. Orphan receptor IL-17RD regulates Toll-like receptor signalling via SEFIR/TIR interactions. Mellett M, et al. Nat Commun, 2015 Mar 26. PMID 25808990

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Endothelial IL17RD promotes Western diet-induced aortic myeloid cell infiltration.
      Title: Endothelial IL17RD promotes Western diet-induced aortic myeloid cell infiltration.
    2. A shedding soluble form of interleukin-17 receptor D exacerbates collagen-induced arthritis through facilitating TNF-alpha-dependent receptor clustering.
      Title: A shedding soluble form of interleukin-17 receptor D exacerbates collagen-induced arthritis through facilitating TNF-α-dependent receptor clustering.
    3. IL-17RD/sef exacerbates experimental mouse colitis and inflammation-associated tumorigenesis by regulating the proportion of T cell subsets.
      Title: IL-17RD/sef exacerbates experimental mouse colitis and inflammation-associated tumorigenesis by regulating the proportion of T cell subsets.
    4. Loss of interleukin-17 receptor D promotes chronic inflammation-associated tumorigenesis.
      Title: Loss of interleukin-17 receptor D promotes chronic inflammation-associated tumorigenesis.
    5. Deficiency of IL-17RD expression in cells leads to enhanced pro-inflammatory signalling and gene expression in response to TLR stimulation, and Il17rd(-/-) mice are more susceptible to TLR-induced septic shock.
      Title: Orphan receptor IL-17RD regulates Toll-like receptor signalling via SEFIR/TIR interactions.
    6. Demonstrate SEF expression in a healthy ovary during folliculogenesis and suggest hormonal regulation of its expression may be an important factor involved in intra-ovarian control mechanisms.
      Title: Expression and regulation of the tumor suppressor, SEF, during folliculogenesis in humans and mice.
    7. these studies indicate that Sef has specific roles in osteoblast and osteoclast lineages and that its absence results in increased osteoblast and osteoclast activity with a net increase in cortical bone mass.
      Title: Deficiency of Sef is associated with increased postnatal cortical bone mass by regulating Runx2 activity.
    8. Orphan receptor IL-17RD tunes IL-17A signalling and is required for neutrophilia.
      Title: Orphan receptor IL-17RD tunes IL-17A signalling and is required for neutrophilia.
    9. Since expression of IL-17 is elevated in 3-month-old MRL/lpr mice, we suggest that it plays a role in the pathophysiology of autoimmune dacryoadenitis in these mice.
      Title: Expression of interleukin-17 in autoimmune dacryoadenitis in MRL/lpr mice.
    10. Over-expressing Sef specifically in the lens of transgenic mice led to impaired lens and eye development that resulted in microphthalmia.
      Title: Sef is a negative regulator of fiber cell differentiation in the ocular lens.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC118454

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables interleukin-17 receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of epithelial to mesenchymal transition IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    interleukin-17 receptor D
    Names
    IL-17 receptor D
    interleukin-17 receptor-like protein
    sef homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411765.1 → NP_001398694.1  interleukin-17 receptor D isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC124603, AC125152

    2. NM_134437.4 → NP_602319.1  interleukin-17 receptor D isoform 1 precursor

      See identical proteins and their annotated locations for NP_602319.1

      Status: VALIDATED

      Source sequence(s)
      AC124603, AC125152
      Consensus CDS
      CCDS26885.1
      UniProtKB/Swiss-Prot
      B2RRY7, Q8JZL1, Q8K447, Q8R5J8
      Related
      ENSMUSP00000036076.4, ENSMUST00000035336.5
      Conserved Domains (2) summary
      pfam08357
      Location:356 → 511
      SEFIR; SEFIR domain
      pfam16742
      Location:48 → 169
      IL17R_D_N; N-terminus of interleukin 17 receptor D

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      26760990..26829243
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006518668.2 → XP_006518731.1  interleukin-17 receptor D isoform X2

      UniProtKB/TrEMBL
      Q3V0D5
      Related
      ENSMUSP00000153543.2, ENSMUST00000225146.2
      Conserved Domains (2) summary
      pfam08357
      Location:212 → 367
      SEFIR; SEFIR domain
      pfam16742
      Location:1 → 25
      IL17R_D_N; N-terminus of interleukin 17 receptor D

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_027265.1: Suppressed sequence

      Description
      NM_027265.1: This RefSeq was permanently suppressed because it is primarily UTR sequence.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8JZL1.1 GenPept UniProtKB/Swiss-Prot:Q8JZL1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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