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    Plekhg1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 [ Mus musculus (house mouse) ]

    Gene ID: 213783, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Plekhg1provided by MGI
    Official Full Name
    pleckstrin homology domain containing, family G (with RhoGef domain) member 1provided by MGI
    Primary source
    MGI:MGI:2676551
    See related
    Ensembl:ENSMUSG00000040624 AllianceGenome:MGI:2676551
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm521; mKIAA1209; D10Ertd733e
    Summary
    Predicted to be located in nucleoplasm. Is expressed in brain; embryo; and retina. Orthologous to human PLEKHG1 (pleckstrin homology and RhoGEF domain containing G1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 3.8), limb E14.5 (RPKM 3.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10 A1; 10 2.06 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (3690206..3917303)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (3740251..3967303)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene iodotyrosine deiodinase Neighboring gene STARR-seq mESC enhancer starr_25674 Neighboring gene RIKEN cDNA A330032P22 gene Neighboring gene predicted gene, 30164 Neighboring gene STARR-seq mESC enhancer starr_25673 Neighboring gene STARR-seq mESC enhancer starr_25672 Neighboring gene STARR-seq mESC enhancer starr_25671 Neighboring gene STARR-seq mESC enhancer starr_25666 Neighboring gene mitochondrial ribosomal protein S36 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2926 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like Neighboring gene ring finger protein 4 pseudogene Neighboring gene STARR-seq mESC enhancer starr_25663 Neighboring gene STARR-seq mESC enhancer starr_25662 Neighboring gene predicted gene, 40591

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The histone H3-lysine 4-methyltransferase Mll4 regulates the development of growth hormone-releasing hormone-producing neurons in the mouse hypothalamus. Huisman C, et al. Nat Commun, 2021 Jan 11. PMID 33431871, Free PMC Article
    2. A Role for Sensory end Organ-Derived Signals in Regulating Muscle Spindle Proprioceptor Phenotype. Wu D, et al. J Neurosci, 2019 May 29. PMID 30926747, Free PMC Article
    3. The spatiotemporal expression pattern of microRNAs in the developing mouse nervous system. Shu P, et al. J Biol Chem, 2019 Mar 8. PMID 30578296, Free PMC Article
    4. Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord. Tamplin OJ, et al. Dev Biol, 2011 Dec 15. PMID 22008794
    5. Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Lumayag S, et al. Proc Natl Acad Sci U S A, 2013 Feb 5. PMID 23341629, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    pleckstrin homology domain-containing family G member 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033253.3 → NP_001028425.1  pleckstrin homology domain-containing family G member 1

      See identical proteins and their annotated locations for NP_001028425.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC153570, AK135923
      Consensus CDS
      CCDS56671.1
      UniProtKB/TrEMBL
      F6S200, Q3UX37
      Related
      ENSMUSP00000040495.7, ENSMUST00000042438.13
      Conserved Domains (2) summary
      cd00160
      Location:114 → 290
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13243
      Location:272 → 417
      PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain

    2. NM_001159942.1 → NP_001153414.1  pleckstrin homology domain-containing family G member 1

      See identical proteins and their annotated locations for NP_001153414.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC153570, AK034403, AK135923
      Consensus CDS
      CCDS56671.1
      UniProtKB/TrEMBL
      F6S200, Q3UX37
      Related
      ENSMUSP00000114056.2, ENSMUST00000120274.8
      Conserved Domains (2) summary
      cd00160
      Location:114 → 290
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13243
      Location:272 → 417
      PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      3690206..3917303
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243078.2 → XP_011241380.1  pleckstrin homology domain-containing family G member 1 isoform X3

      See identical proteins and their annotated locations for XP_011241380.1

      UniProtKB/TrEMBL
      F6S200, Q3UX37
      Conserved Domains (2) summary
      cd00160
      Location:114 → 290
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13243
      Location:272 → 417
      PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain

    2. XM_011243077.2 → XP_011241379.1  pleckstrin homology domain-containing family G member 1 isoform X3

      See identical proteins and their annotated locations for XP_011241379.1

      UniProtKB/TrEMBL
      F6S200, Q3UX37
      Conserved Domains (2) summary
      cd00160
      Location:114 → 290
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13243
      Location:272 → 417
      PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain

    3. XM_006512439.5 → XP_006512502.1  pleckstrin homology domain-containing family G member 1 isoform X1

      UniProtKB/TrEMBL
      A0A5F8MPP0
      Related
      ENSMUSP00000159056.2, ENSMUST00000239159.2
      Conserved Domains (2) summary
      cd00160
      Location:211 → 387
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13243
      Location:369 → 514
      PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain

    4. XM_006512442.5 → XP_006512505.1  pleckstrin homology domain-containing family G member 1 isoform X2

      UniProtKB/TrEMBL
      F6S200
      Conserved Domains (2) summary
      cd00160
      Location:154 → 330
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13243
      Location:312 → 457
      PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain

    5. XM_006512443.5 → XP_006512506.1  pleckstrin homology domain-containing family G member 1 isoform X3

      See identical proteins and their annotated locations for XP_006512506.1

      UniProtKB/TrEMBL
      F6S200, Q3UX37
      Conserved Domains (2) summary
      cd00160
      Location:114 → 290
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13243
      Location:272 → 417
      PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain

    RNA

    1. XR_004936151.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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