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    Ranbp17 RAN binding protein 17 [ Mus musculus (house mouse) ]

    Gene ID: 66011, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Ranbp17provided by MGI
    Official Full Name
    RAN binding protein 17provided by MGI
    Primary source
    MGI:MGI:1929706
    See related
    Ensembl:ENSMUSG00000040594 AllianceGenome:MGI:1929706
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable nuclear export signal receptor activity. Predicted to be involved in protein export from nucleus. Predicted to act upstream of or within nucleocytoplasmic transport. Predicted to be located in nucleus. Predicted to be part of nuclear pore. Predicted to be active in cytoplasm. Orthologous to human RANBP17 (RAN binding protein 17). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 5.0), CNS E11.5 (RPKM 1.1) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 A4; 11 19.21 cM
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (33161794..33463789, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (33211794..33513784, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12115 Neighboring gene T cell leukemia, homeobox 3 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene acidic (leucine-rich) nuclear phosphoprotein 32 family, pseudogene Neighboring gene mediator complex subunit 29 pseudogene Neighboring gene high mobility group box 2 pseudogene Neighboring gene CRISPRi-validated Ranbp17 enhancer cluster Neighboring gene STARR-seq mESC enhancer starr_29136 Neighboring gene predicted gene, 36005 Neighboring gene gamma-aminobutyric acid type A receptor subunit pi

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RANBP17 is localized to the XY body of spermatocytes and interacts with SPEM1 on the manchette of elongating spermatids. Bao J, et al. Mol Cell Endocrinol, 2011 Feb 20. PMID 21184802, Free PMC Article
    2. Identification of a novel putative Ran-binding protein and its close homologue. Koch P, et al. Biochem Biophys Res Commun, 2000 Nov 11. PMID 11071879
    3. Tagging genes with cassette-exchange sites. Cobellis G, et al. Nucleic Acids Res, 2005 Mar 1. PMID 15741177, Free PMC Article
    4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interactions between RANBP17 and SPEM1, for the first time, point to a potential function of SPEM1 in the RANBP17-mediated nucleocytoplasmic transport.
      Title: RANBP17 is localized to the XY body of spermatocytes and interacts with SPEM1 on the manchette of elongating spermatids.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • 4932704E15Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nuclear export signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within nucleocytoplasmic transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protein export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ran-binding protein 17

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362875.1 → NP_001349804.1  ran-binding protein 17 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL669814, AL683843, AL772409
      UniProtKB/TrEMBL
      Q8BWS4
      Conserved Domains (2) summary
      smart00913
      Location:30 → 95
      IBN_N; Importin-beta N-terminal domain
      cl26694
      Location:8 → 167
      Xpo1; Exportin 1-like protein

    2. NM_023146.3 → NP_075635.1  ran-binding protein 17 isoform 1

      See identical proteins and their annotated locations for NP_075635.1

      Status: VALIDATED

      Source sequence(s)
      AK016583, AL669814, AL683843, AL772409, BY731762
      Consensus CDS
      CCDS24534.1
      UniProtKB/Swiss-Prot
      Q99NF8, Q9D4E3
      UniProtKB/TrEMBL
      Q8BWS4
      Related
      ENSMUSP00000099879.4, ENSMUST00000102815.10
      Conserved Domains (1) summary
      pfam03810
      Location:30 → 95
      IBN_N; Importin-beta N-terminal domain

    RNA

    1. NR_110973.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK035897, AK050150, AL669814, AL772409, BY731762, CB527189

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      33161794..33463789 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514776.5 → XP_006514839.1  ran-binding protein 17 isoform X1

      UniProtKB/TrEMBL
      Q8BWS4
      Conserved Domains (2) summary
      smart00913
      Location:30 → 95
      IBN_N; Importin-beta N-terminal domain
      COG5101
      Location:8 → 167
      CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]

    2. XM_011243739.4 → XP_011242041.1  ran-binding protein 17 isoform X2

      UniProtKB/TrEMBL
      Q8BWS4
      Conserved Domains (2) summary
      smart00913
      Location:30 → 95
      IBN_N; Importin-beta N-terminal domain
      COG5101
      Location:8 → 167
      CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]

    RNA

    1. XR_380976.5 RNA Sequence

    2. XR_380979.5 RNA Sequence

    3. XR_380977.5 RNA Sequence

    4. XR_003949487.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99NF8.1 GenPept UniProtKB/Swiss-Prot:Q99NF8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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