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    Gpr63 G protein-coupled receptor 63 [ Mus musculus (house mouse) ]

    Gene ID: 81006, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Gpr63provided by MGI
    Official Full Name
    G protein-coupled receptor 63provided by MGI
    Primary source
    MGI:MGI:2135884
    See related
    Ensembl:ENSMUSG00000040372 AllianceGenome:MGI:2135884
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Psp24-2; PSP24beta
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within signal transduction. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Is expressed in gut; male reproductive gland or organ; metanephros; nervous system; and thymus. Orthologous to human GPR63 (G protein-coupled receptor 63). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cerebellum adult (RPKM 4.1), CNS E18 (RPKM 1.2) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gpr63 in Genome Data Viewer
    Location:
    4 A3; 4 10.53 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (24966054..25012726)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (24966054..25009238)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31379 Neighboring gene STARR-seq mESC enhancer starr_09783 Neighboring gene predicted gene, 46848 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 4 Neighboring gene RIKEN cDNA C230012O17 gene Neighboring gene four and a half LIM domains 5 Neighboring gene UFM1 specific ligase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Gpr63 is a modifier of microcephaly in Ttc21b mouse mutants. Snedeker J, et al. PLoS Genet, 2019 Nov. PMID 31730647, Free PMC Article
    2. Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45. Kawasawa Y, et al. Biochem Biophys Res Commun, 2000 Oct 5. PMID 11027574
    3. Atlas of gene expression in the developing kidney at microanatomic resolution. Brunskill EW, et al. Dev Cell, 2008 Nov. PMID 19000842, Free PMC Article
    4. Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Ghai R, et al. Proc Natl Acad Sci U S A, 2013 Feb 19. PMID 23382219, Free PMC Article
    5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    probable G-protein coupled receptor 63
    Names
    G protein-coupled receptor PSP24-2
    PSP24-beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001379626.1 → NP_001366555.1  probable G-protein coupled receptor 63

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AL772199, AL772223
      UniProtKB/Swiss-Prot
      Q8BZ93, Q9EQQ3
      Conserved Domains (1) summary
      cd15404
      Location:88 → 388
      7tmA_GPR63; G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_001379627.1 → NP_001366556.1  probable G-protein coupled receptor 63

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AL772199, AL772223
      UniProtKB/Swiss-Prot
      Q8BZ93, Q9EQQ3
      Conserved Domains (1) summary
      cd15404
      Location:88 → 388
      7tmA_GPR63; G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. NM_030733.4 → NP_109658.2  probable G-protein coupled receptor 63

      See identical proteins and their annotated locations for NP_109658.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 all encode the same protein.
      Source sequence(s)
      AL772199, AL772223
      Consensus CDS
      CCDS18008.1
      UniProtKB/Swiss-Prot
      Q8BZ93, Q9EQQ3
      Related
      ENSMUSP00000039312.2, ENSMUST00000038920.2
      Conserved Domains (1) summary
      cd15404
      Location:88 → 388
      7tmA_GPR63; G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      24966054..25012726
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538383.5 → XP_006538446.1  probable G-protein coupled receptor 63 isoform X1

      See identical proteins and their annotated locations for XP_006538446.1

      UniProtKB/Swiss-Prot
      Q8BZ93, Q9EQQ3
      Conserved Domains (1) summary
      cd15404
      Location:88 → 388
      7tmA_GPR63; G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9EQQ3.2 GenPept UniProtKB/Swiss-Prot:Q9EQQ3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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