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    Gpr26 G protein-coupled receptor 26 [ Mus musculus (house mouse) ]

    Gene ID: 233919, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Gpr26provided by MGI
    Official Full Name
    G protein-coupled receptor 26provided by MGI
    Primary source
    MGI:MGI:2441758
    See related
    Ensembl:ENSMUSG00000040125 AllianceGenome:MGI:2441758
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A730021D22; 9630036A11Rik
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to act upstream of or within signal transduction. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Is expressed in central nervous system. Orthologous to human GPR26 (G protein-coupled receptor 26). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cortex adult (RPKM 6.7), frontal lobe adult (RPKM 5.3) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 F3; 7 75.28 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (131567891..131587362)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (131966162..131985633)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33146 Neighboring gene predicted gene, 34725 Neighboring gene STARR-seq mESC enhancer starr_20288 Neighboring gene carboxypeptidase X, M14 family member 2 Neighboring gene STARR-seq mESC enhancer starr_20291 Neighboring gene carbohydrate sulfotransferase 15 Neighboring gene STARR-positive B cell enhancer ABC_E8215 Neighboring gene predicted gene 10584

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Constitutive activity of GPR26 regulated by ubiquitin-dependent degradation and its antitumor role. Liu F, et al. FEBS J, 2021 Aug. PMID 33577134
    2. GPR26-deficient mice display increased anxiety- and depression-like behaviors accompanied by reduced phosphorylated cyclic AMP responsive element-binding protein level in central amygdala. Zhang LL, et al. Neuroscience, 2011 Nov 24. PMID 21924326
    3. Targeted inactivation of GPR26 leads to hyperphagia and adiposity by activating AMPK in the hypothalamus. Chen D, et al. PLoS One, 2012. PMID 22815809, Free PMC Article
    4. Tissue distribution and functional analyses of the constitutively active orphan G protein coupled receptors, GPR26 and GPR78. Jones PG, et al. Biochim Biophys Acta, 2007 Jun. PMID 17363172
    5. Tlx3 Exerts Direct Control in Specifying Excitatory Over Inhibitory Neurons in the Dorsal Spinal Cord. Monteiro FA, et al. Front Cell Dev Biol, 2021. PMID 33996801, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Constitutive activity of GPR26 regulated by ubiquitin-dependent degradation and its antitumor role.
      Title: Constitutive activity of GPR26 regulated by ubiquitin-dependent degradation and its antitumor role.
    2. These findings identified a key role of GPR26 as a central regulator of energy homeostasis though modulation of hypothalamic AMPK activation.
      Title: Targeted inactivation of GPR26 leads to hyperphagia and adiposity by activating AMPK in the hypothalamus.
    3. data indicate that Gpr26 is important for emotion regulation in mice, a function probably mediated by the phosphorylation of CREB in the central amygdala.
      Title: GPR26-deficient mice display increased anxiety- and depression-like behaviors accompanied by reduced phosphorylated cyclic AMP responsive element-binding protein level in central amygdala.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    G-protein coupled receptor 26

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173410.3 → NP_775586.1  G-protein coupled receptor 26

      See identical proteins and their annotated locations for NP_775586.1

      Status: PROVISIONAL

      Source sequence(s)
      AC105062
      Consensus CDS
      CCDS21920.1
      UniProtKB/Swiss-Prot
      Q80T55, Q8BXZ5, Q8BZA7
      UniProtKB/TrEMBL
      Q0VBG4
      Related
      ENSMUSP00000041664.5, ENSMUST00000045840.5
      Conserved Domains (1) summary
      cd15219
      Location:7 → 305
      7tmA_GPR26_GPR78-like; G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      131567891..131587362
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507766.4 → XP_006507829.1  G-protein coupled receptor 26 isoform X1

      Conserved Domains (2) summary
      cd14964
      Location:7 → 33
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:7 → 261
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BZA7.1 GenPept UniProtKB/Swiss-Prot:Q8BZA7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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