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    Mrap melanocortin 2 receptor accessory protein [ Mus musculus (house mouse) ]

    Gene ID: 77037, updated on 5-Mar-2024

    Summary

    Official Symbol
    Mrapprovided by MGI
    Official Full Name
    melanocortin 2 receptor accessory proteinprovided by MGI
    Primary source
    MGI:MGI:1924287
    See related
    Ensembl:ENSMUSG00000039956 AllianceGenome:MGI:1924287
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Falp; ORF61; C21ORF61; 1110025G12Rik
    Summary
    Predicted to enable identical protein binding activity; melanocortin receptor binding activity; and signaling receptor regulator activity. Acts upstream of or within brown fat cell differentiation. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in endoplasmic reticulum and plasma membrane. Is expressed in several structures, including brain; olfactory epithelium; respiratory system; salivary gland; and urinary system. Used to study adrenal gland disease. Human ortholog(s) of this gene implicated in familial glucocorticoid deficiency. Orthologous to human MRAP (melanocortin 2 receptor accessory protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in adrenal adult (RPKM 314.9), subcutaneous fat pad adult (RPKM 188.2) and 6 other tissues See more
    Orthologs
    NEW
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    Genomic context

    Location:
    16 C3.3; 16 51.9 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (90535095..90546673)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (90738207..90749785)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr16:90727472-90727773 Neighboring gene MIS18 kinetochore protein A Neighboring gene predicted gene, 17518 Neighboring gene URB1 ribosome biogenesis 1 homolog (S. cerevisiae) Neighboring gene STARR-seq mESC enhancer starr_41464 Neighboring gene STARR-positive B cell enhancer ABC_E1929 Neighboring gene eva-1 homolog C Neighboring gene predicted gene, 36363

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables corticotropin hormone receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables corticotropin hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables type 1 melanocortin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables type 1 melanocortin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables type 3 melanocortin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables type 3 melanocortin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables type 4 melanocortin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables type 4 melanocortin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables type 5 melanocortin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables type 5 melanocortin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    melanocortin-2 receptor accessory protein
    Names
    fat cell-specific low molecular weight protein
    fat tissue-specific low MW protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029844.4NP_084120.1  melanocortin-2 receptor accessory protein

      See identical proteins and their annotated locations for NP_084120.1

      Status: VALIDATED

      Source sequence(s)
      AC126671
      Consensus CDS
      CCDS28317.1
      UniProtKB/Swiss-Prot
      Q3TZ49, Q8R439, Q9D159
      Related
      ENSMUSP00000043890.3, ENSMUST00000038197.3
      Conserved Domains (1) summary
      pfam15183
      Location:189
      MRAP; Melanocortin-2 receptor accessory protein family

    RNA

    1. NR_155757.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC126671
    2. NR_155758.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC126671
      Related
      ENSMUST00000125429.3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      90535095..90546673
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)