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    Fnbp1l formin binding protein 1-like [ Mus musculus (house mouse) ]

    Gene ID: 214459, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Fnbp1lprovided by MGI
    Official Full Name
    formin binding protein 1-likeprovided by MGI
    Primary source
    MGI:MGI:1925642
    See related
    Ensembl:ENSMUSG00000039735 AllianceGenome:MGI:1925642
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TOCA1; toca-1; 2610318I01Rik
    Summary
    Predicted to enable GTPase binding activity. Predicted to be involved in several processes, including plasma membrane tubulation; positive regulation of filopodium assembly; and vesicle transport along actin filament. Predicted to act upstream of or within cilium assembly. Predicted to be located in cytoplasmic vesicle and cytosol. Is expressed in central nervous system; dorsal root ganglion; gut; male reproductive gland or organ; and neural retina. Orthologous to human FNBP1L (formin binding protein 1 like). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in CNS E18 (RPKM 92.2), CNS E14 (RPKM 86.3) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fnbp1l in Genome Data Viewer
    Location:
    3 G1; 3 53.63 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (122332368..122413363, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (122538719..122619714, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2681 Neighboring gene STARR-positive B cell enhancer ABC_E9224 Neighboring gene STARR-positive B cell enhancer ABC_E11214 Neighboring gene predicted gene, 57718 Neighboring gene STARR-positive B cell enhancer ABC_E6115 Neighboring gene breast cancer anti-estrogen resistance 3 Neighboring gene STARR-positive B cell enhancer mm9_chr3:122165198-122165499 Neighboring gene STARR-seq mESC enhancer starr_08882 Neighboring gene STARR-seq mESC enhancer starr_08885 Neighboring gene predicted gene, 34349 Neighboring gene microRNA 7657 Neighboring gene STARR-seq mESC enhancer starr_08890 Neighboring gene STARR-seq mESC enhancer starr_08892 Neighboring gene predicted gene 43568 Neighboring gene eptidyl-prolyl cis-trans isomerase A pseudogene 3_2252.1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Myogenesis defect due to Toca-1 knockdown can be suppressed by expression of N-WASP. George B, et al. Biochim Biophys Acta, 2014 Sep. PMID 24861867
    2. Identification and characterization of human FNBP1L gene in silico. Katoh M, et al. Int J Mol Med, 2004 Jan. PMID 14654988
    3. miR-129-3p controls cilia assembly by regulating CP110 and actin dynamics. Cao J, et al. Nat Cell Biol, 2012 Jun 10. PMID 22684256
    4. Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes. Bulfone A, et al. J Neurosci, 2005 Aug 17. PMID 16107646, Free PMC Article
    5. Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Miller JA, et al. Development, 2013 Nov. PMID 24154525, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC30506

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in clathrin-dependent endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in membrane invagination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in plasma membrane tubulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle budding from membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle transport along actin filament ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    formin-binding protein 1-like
    Names
    transducer of Cdc42-dependent actin assembly protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114665.2 → NP_001108137.1  formin-binding protein 1-like isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC099584, AC138720
      Consensus CDS
      CCDS51062.1
      UniProtKB/TrEMBL
      A0A5F8MPQ8, E9PUI5
      Related
      ENSMUSP00000124947.2, ENSMUST00000162947.3
      Conserved Domains (3) summary
      cd07675
      Location:5 → 256
      F-BAR_FNBP1L; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 1-Like
      cd11628
      Location:399 → 479
      HR1_CIP4_FNBP1L; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of vertebrate Cdc42-Interacting Protein 4 and FormiN Binding Protein 1-Like
      cd12072
      Location:541 → 597
      SH3_FNBP1L; Src Homology 3 domain of Formin Binding Protein 1-Like

    2. NM_153118.3 → NP_694758.2  formin-binding protein 1-like isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two in-frame exons in the coding region compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
      Source sequence(s)
      AC099584, AC138720
      Consensus CDS
      CCDS17811.2
      UniProtKB/TrEMBL
      A0A5F8MPQ8, E9PUK3
      Related
      ENSMUSP00000124439.2, ENSMUST00000162409.8
      Conserved Domains (3) summary
      cd07675
      Location:5 → 256
      F-BAR_FNBP1L; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 1-Like
      cd11628
      Location:341 → 421
      HR1_CIP4_FNBP1L; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of vertebrate Cdc42-Interacting Protein 4 and FormiN Binding Protein 1-Like
      cd12072
      Location:483 → 539
      SH3_FNBP1L; Src Homology 3 domain of Formin Binding Protein 1-Like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      122332368..122413363 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K012.2 GenPept UniProtKB/Swiss-Prot:Q8K012

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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