Igfbp2 insulin-like growth factor binding protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Igfbp2provided by MGI
Official Full Name: insulin-like growth factor binding protein 2provided by MGI
Primary source: MGI:MGI:96437
See related: Ensembl:ENSMUSG00000039323 AllianceGenome:MGI:96437
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IBP-2; Igfbp-2; mIGFBP-2
Summary: The protein encoded by this gene is one of several similar proteins that bind insulin-like growth factors I and II (Igf-I and Igf-II). The encoded protein can be secreted into the bloodstream, where it binds Igf-I and Igf-II with high affinity, or it can remain intracellular, interacting with many different ligands. Two transcript variants, one encoding a secreted isoform and the other encoding a nonsecreted isoform, have been found for this gene. [provided by RefSeq, Sep 2015]
Expression: Biased expression in bladder adult (RPKM 311.4), liver E18 (RPKM 285.8) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 C3; 1 36.94 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (72863650..72891633)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (72824480..72852474)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The role of HMGA2 in activating the IGFBP2 expression to promote angiogenesis and LUAD metastasis via the PI3K/AKT/VEGFA signaling pathway.
Title: The role of HMGA2 in activating the IGFBP2 expression to promote angiogenesis and LUAD metastasis via the PI3K/AKT/VEGFA signaling pathway.
Loss of IGFBP2 mediates alveolar type 2 cell senescence and promotes lung fibrosis.
Title: Loss of IGFBP2 mediates alveolar type 2 cell senescence and promotes lung fibrosis.
FGF1 ameliorates obesity-associated hepatic steatosis by reversing IGFBP2 hypermethylation.
Title: FGF1 ameliorates obesity-associated hepatic steatosis by reversing IGFBP2 hypermethylation.
Insulin-like growth factor binding protein 2 null mice (Igfbp2-/-) are protected against trabecular bone loss after vertical sleeve gastrectomy.
Title: Insulin-like growth factor binding protein 2 null mice (Igfbp2-/-) are protected against trabecular bone loss after vertical sleeve gastrectomy.
Serum insulin-like growth factor binding protein 2 levels as biomarker for pancreatic ductal adenocarcinoma-associated malnutrition and muscle wasting.
Title: Serum insulin-like growth factor binding protein 2 levels as biomarker for pancreatic ductal adenocarcinoma-associated malnutrition and muscle wasting.
Sex-Specific Control of Muscle Mass: Elevated IGFBP Proteolysis and Reductions of IGF-1 Levels Are Associated with Substantial Loss of Carcass Weight in Male DU6PxIGFBP-2 Transgenic Mice.
Title: Sex-Specific Control of Muscle Mass: Elevated IGFBP Proteolysis and Reductions of IGF-1 Levels Are Associated with Substantial Loss of Carcass Weight in Male DU6PxIGFBP-2 Transgenic Mice.
Physiological Disturbance in Fatty Liver Energy Metabolism Converges on IGFBP2 Abundance and Regulation in Mice and Men.
Title: Physiological Disturbance in Fatty Liver Energy Metabolism Converges on IGFBP2 Abundance and Regulation in Mice and Men.
Downregulated microRNA-130b-5p prevents lipid accumulation and insulin resistance in a murine model of nonalcoholic fatty liver disease.
Title: Downregulated microRNA-130b-5p prevents lipid accumulation and insulin resistance in a murine model of nonalcoholic fatty liver disease.
An integrative systems approach identifies IGFBP-2, Mfap4, and Spp1 as novel candidates in Marfan syndrome-related pathophysiology.
Title: An integrative systems approach identifies novel candidates in Marfan syndrome-related pathophysiology.
Study in syngeneic mouse glioblastoma (GBM) model, human GBM samples, and cancer-immune cell co-culture revealed that IGFBP2-promoted immunosuppression associated with its induction of the mesenchymal feature of GBM cells and the inhibitory phosphorylated FcgammaRIIB of GBM exposed immune cells. Inhibition of IGFBP2 relieved immunosuppression by increasing CD8+ T and CD19+ B cells and decreasing CD163+ M2 macrophages.
Title: IGFBP2 promotes immunosuppression associated with its mesenchymal induction and FcγRIIB phosphorylation in glioblastoma.

Submit: New GeneRIF Correction See all GeneRIFs (47)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (1) 1 citation
Endonuclease-mediated (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Igfbp2 (e-PCR), detects polymorphism
- UniSTS:471313

L05439 (e-PCR)
- UniSTS:158806

NoName (e-PCR)
- UniSTS:548458

Igfbp2 (e-PCR), detects polymorphism
- UniSTS:143487

Igfbp2 (e-PCR), detects polymorphism
- UniSTS:461977

AI255832 (e-PCR)
- UniSTS:178409

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables growth factor binding	IEA Inferred from Electronic Annotation more info
enables insulin-like growth factor I binding	IBA Inferred from Biological aspect of Ancestor more info
enables insulin-like growth factor I binding	ISO Inferred from Sequence Orthology more info
enables insulin-like growth factor II binding	IBA Inferred from Biological aspect of Ancestor more info
enables insulin-like growth factor II binding	ISO Inferred from Sequence Orthology more info
enables insulin-like growth factor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of activated T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of insulin-like growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: insulin-like growth factor-binding protein 2

Names: IGF-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001310659.2 → NP_001297588.1 insulin-like growth factor-binding protein 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC115870, AC121498

Consensus CDS

CCDS78613.1

UniProtKB/TrEMBL

D3YU40

Related

ENSMUSP00000112706.2, ENSMUST00000120564.2

Conserved Domains (1) summary

pfam00086
Location:60 → 139

Thyroglobulin_1; Thyroglobulin type-1 repeat
NM_001420245.1 → NP_001407174.1 insulin-like growth factor-binding protein 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC115870, AC121498

UniProtKB/TrEMBL

D3YU40
NM_008342.4 → NP_032368.2 insulin-like growth factor-binding protein 2 isoform 1 precursor

See identical proteins and their annotated locations for NP_032368.2

Status: VALIDATED

Source sequence(s)

AC115870, AC121498

Consensus CDS

CCDS15036.1

UniProtKB/Swiss-Prot

P47877, Q61722, Q91VK7

UniProtKB/TrEMBL

Q9D057

Related

ENSMUSP00000046610.5, ENSMUST00000047328.11

Conserved Domains (2) summary

smart00121
Location:38 → 116

IB; Insulin growth factor-binding protein homologues

pfam00086
Location:207 → 286

Thyroglobulin_1; Thyroglobulin type-1 repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

72863650..72891633

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030250357.2 → XP_030106217.1 insulin-like growth factor-binding protein 2 isoform X1

UniProtKB/TrEMBL

D3YU40

Conserved Domains (1) summary

pfam00086
Location:60 → 139

Thyroglobulin_1; Thyroglobulin type-1 repeat