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    Slco4a1 solute carrier organic anion transporter family, member 4a1 [ Mus musculus (house mouse) ]

    Gene ID: 108115, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Slco4a1provided by MGI
    Official Full Name
    solute carrier organic anion transporter family, member 4a1provided by MGI
    Primary source
    MGI:MGI:1351866
    See related
    Ensembl:ENSMUSG00000038963 AllianceGenome:MGI:1351866
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    OATP-E; Slc21a12
    Summary
    Predicted to enable sodium-independent organic anion transmembrane transporter activity and thyroid hormone transmembrane transporter activity. Predicted to be involved in sodium-independent organic anion transport and thyroid hormone metabolic process. Predicted to act upstream of or within organic anion transport. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in central nervous system; hippocampus; retina inner nuclear layer; retina layer; and retina outer nuclear layer. Orthologous to human SLCO4A1 (solute carrier organic anion transporter family member 4A1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in kidney adult (RPKM 15.2), genital fat pad adult (RPKM 12.7) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 H4; 2 102.99 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (180098019..180116646)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (180456226..180474853)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene Mir1a-1 and Mir133a-2 host gene Neighboring gene microRNA 1a-1 Neighboring gene microRNA 133a-2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:180171931-180172146 Neighboring gene STARR-positive B cell enhancer mm9_chr2:180178418-180178718 Neighboring gene STARR-seq mESC enhancer starr_06732 Neighboring gene neurotensin receptor 1 Neighboring gene predicted gene, 30144 Neighboring gene STARR-positive B cell enhancer ABC_E9543 Neighboring gene MRG/MORF4L binding protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Solute carrier organic anion transporter family member 4A1 promotes colorectal cancer progression and is regulated by miR-1224-5p. Jiang Y, et al. Neoplasma, 2022 Jul. PMID 35331000
    2. Developmental and cell type-specific expression of thyroid hormone transporters in the mouse brain and in primary brain cells. Braun D, et al. Glia, 2011 Mar. PMID 21264952
    3. Molecular physiology of renal organic anion transporters. Sekine T, et al. Am J Physiol Renal Physiol, 2006 Feb. PMID 16403838
    4. Neuronal 3',3,5-triiodothyronine (T3) uptake and behavioral phenotype of mice deficient in Mct8, the neuronal T3 transporter mutated in Allan-Herndon-Dudley syndrome. Wirth EK, et al. J Neurosci, 2009 Jul 29. PMID 19641107, Free PMC Article
    5. Maternal bile acid transporter deficiency promotes neonatal demise. Zhang Y, et al. Nat Commun, 2015 Sep 29. PMID 26416771, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Solute carrier organic anion transporter family member 4A1 promotes colorectal cancer progression and is regulated by miR-1224-5p.
      Title: Solute carrier organic anion transporter family member 4A1 promotes colorectal cancer progression and is regulated by miR-1224-5p.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC28799, MGC28824

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables organic anion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables prostaglandin transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sodium-independent organic anion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thyroid hormone transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thyroid hormone transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium-independent organic anion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in thyroid hormone metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier organic anion transporter family member 4A1
    Names
    organic anion-transporting polypeptide E
    sodium-independent organic anion transporter E
    solute carrier family 21 (organic anion transporter), member 12
    solute carrier family 21 member 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355218.1 → NP_001342147.1  solute carrier organic anion transporter family member 4A1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AK033598, AL669926
      Consensus CDS
      CCDS17176.1
      UniProtKB/Swiss-Prot
      Q8BZT4, Q8K078
      Related
      ENSMUSP00000046502.7, ENSMUST00000038259.13
      Conserved Domains (1) summary
      pfam03137
      Location:103 → 665
      OATP; Organic Anion Transporter Polypeptide (OATP) family

    2. NM_148933.1 → NP_683735.1  solute carrier organic anion transporter family member 4A1

      See identical proteins and their annotated locations for NP_683735.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      BC030719
      Consensus CDS
      CCDS17176.1
      UniProtKB/Swiss-Prot
      Q8BZT4, Q8K078
      Related
      ENSMUSP00000045023.8, ENSMUST00000038225.8
      Conserved Domains (1) summary
      pfam03137
      Location:103 → 665
      OATP; Organic Anion Transporter Polypeptide (OATP) family

    RNA

    1. NR_149314.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' end, contains an alternate internal exon, and lacks another alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL669926

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      180098019..180116646
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157372.1 → XP_036013265.1  solute carrier organic anion transporter family member 4A1 isoform X2

      Related
      ENSMUST00000139902.8
      Conserved Domains (1) summary
      cl28910
      Location:5 → 313
      MFS; Major Facilitator Superfamily

    2. XM_036157366.1 → XP_036013259.1  solute carrier organic anion transporter family member 4A1 isoform X1

      Conserved Domains (1) summary
      cl28910
      Location:11 → 318
      MFS; Major Facilitator Superfamily

    3. XM_036157369.1 → XP_036013262.1  solute carrier organic anion transporter family member 4A1 isoform X2

      Conserved Domains (1) summary
      cl28910
      Location:5 → 313
      MFS; Major Facilitator Superfamily

    4. XM_036157367.1 → XP_036013260.1  solute carrier organic anion transporter family member 4A1 isoform X1

      Conserved Domains (1) summary
      cl28910
      Location:11 → 318
      MFS; Major Facilitator Superfamily

    RNA

    1. XR_003949978.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K078.2 GenPept UniProtKB/Swiss-Prot:Q8K078

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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