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    Gmeb2 glucocorticoid modulatory element binding protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 229004, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Gmeb2provided by MGI
    Official Full Name
    glucocorticoid modulatory element binding protein 2provided by MGI
    Primary source
    MGI:MGI:2652836
    See related
    Ensembl:ENSMUSG00000038705 AllianceGenome:MGI:2652836
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in 1st branchial arch and heart. Orthologous to human GMEB2 (glucocorticoid modulatory element binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 14.6), colon adult (RPKM 10.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 H4; 2 103.63 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (180893240..180933481, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (181251449..181288106, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4531 Neighboring gene fibronectin type III domain containing 11 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene helicase with zinc finger 2, transcriptional coactivator Neighboring gene proviral integration site 2 pseudogene Neighboring gene stathmin-like 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    2. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142, Free PMC Article
    3. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glucocorticoid modulatory element-binding protein 2
    Names
    GMEB-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419396.1 → NP_001406325.1  glucocorticoid modulatory element-binding protein 2

      Status: VALIDATED

      Source sequence(s)
      AL845506
      UniProtKB/Swiss-Prot
      P58929, Q6PCY0

    2. NM_001419397.1 → NP_001406326.1  glucocorticoid modulatory element-binding protein 2

      Status: VALIDATED

      Source sequence(s)
      AL845506
      UniProtKB/Swiss-Prot
      P58929, Q6PCY0

    3. NM_198169.3 → NP_937812.1  glucocorticoid modulatory element-binding protein 2

      See identical proteins and their annotated locations for NP_937812.1

      Status: VALIDATED

      Source sequence(s)
      AL845506
      Consensus CDS
      CCDS17206.1
      UniProtKB/Swiss-Prot
      P58929, Q6PCY0
      Related
      ENSMUSP00000037075.7, ENSMUST00000049032.13
      Conserved Domains (1) summary
      smart00258
      Location:90 → 163
      SAND; SAND domain

    RNA

    1. NR_185068.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL845506

    2. NR_185069.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL845506

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      180893240..180933481 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011239938.3 → XP_011238240.1  glucocorticoid modulatory element-binding protein 2 isoform X3

      See identical proteins and their annotated locations for XP_011238240.1

      UniProtKB/TrEMBL
      Q6ZPV0
      Conserved Domains (1) summary
      cl02536
      Location:7 → 51
      SAND; SAND domain

    2. XM_006500604.3 → XP_006500667.1  glucocorticoid modulatory element-binding protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006500667.1

      UniProtKB/Swiss-Prot
      P58929, Q6PCY0
      Conserved Domains (1) summary
      smart00258
      Location:90 → 163
      SAND; SAND domain

    3. XM_006500602.3 → XP_006500665.1  glucocorticoid modulatory element-binding protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006500665.1

      UniProtKB/Swiss-Prot
      P58929, Q6PCY0
      Conserved Domains (1) summary
      smart00258
      Location:90 → 163
      SAND; SAND domain

    4. XM_006500605.4 → XP_006500668.1  glucocorticoid modulatory element-binding protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006500668.1

      UniProtKB/Swiss-Prot
      P58929, Q6PCY0
      Conserved Domains (1) summary
      smart00258
      Location:90 → 163
      SAND; SAND domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P58929.2 GenPept UniProtKB/Swiss-Prot:P58929

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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