Tmco3 transmembrane and coiled-coil domains 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmco3provided by MGI
Official Full Name: transmembrane and coiled-coil domains 3provided by MGI
Primary source: MGI:MGI:2444946
See related: Ensembl:ENSMUSG00000038497 AllianceGenome:MGI:2444946
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: B230339H12Rik
Summary: Predicted to enable solute:proton antiporter activity. Predicted to be involved in cation transport and transmembrane transport. Predicted to act upstream of or within ion transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including cardiovascular system; central nervous system; gut; male reproductive gland or organ; and respiratory system. Orthologous to human TMCO3 (transmembrane and coiled-coil domains 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in colon adult (RPKM 21.8), kidney adult (RPKM 11.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 A1.1; 8 5.73 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (13333214..13372924)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (13288013..13322924)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TMCO3, a Putative K[+] :Proton Antiporter at the Golgi Apparatus, Is Important for Longitudinal Growth in Mice and Humans.
Title: TMCO3, a Putative K(+) :Proton Antiporter at the Golgi Apparatus, Is Important for Longitudinal Growth in Mice and Humans.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

RH136612 (e-PCR)
- UniSTS:210592

C87304 (e-PCR)
- UniSTS:179704

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables antiporter activity	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info
enables potassium:proton antiporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in monoatomic cation transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transmembrane and coiled-coil domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001364217.1 → NP_001351146.1 transmembrane and coiled-coil domain-containing protein 3 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AK046065, AK148252

Conserved Domains (2) summary

pfam00999
Location:274 → 645

Na_H_Exchanger; Sodium/hydrogen exchanger family

cl25732
Location:61 → 253

SMC_N; RecF/RecN/SMC N terminal domain
NM_172282.2 → NP_758486.1 transmembrane and coiled-coil domain-containing protein 3 isoform 1 precursor

See identical proteins and their annotated locations for NP_758486.1

Status: VALIDATED

Source sequence(s)

AK033499, AK148252, BY146007

Consensus CDS

CCDS40231.1

UniProtKB/Swiss-Prot

Q3UFX1, Q7TMT5, Q8BGL4, Q8BH01, Q8R303

Related

ENSMUSP00000040347.6, ENSMUST00000045229.7

Conserved Domains (2) summary

pfam00999
Location:274 → 646

Na_H_Exchanger; Sodium/hydrogen exchanger family

pfam01519
Location:88 → 195

DUF16; Protein of unknown function DUF16

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

13333214..13372924

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036153885.1 → XP_036009778.1 transmembrane and coiled-coil domain-containing protein 3 isoform X1

Conserved Domains (2) summary

COG1196
Location:61 → 253

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cl01133
Location:274 → 356

Na_H_Exchanger; Sodium/hydrogen exchanger family