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    Asb10 ankyrin repeat and SOCS box-containing 10 [ Mus musculus (house mouse) ]

    Gene ID: 117590, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Asb10provided by MGI
    Official Full Name
    ankyrin repeat and SOCS box-containing 10provided by MGI
    Primary source
    MGI:MGI:2152836
    See related
    Ensembl:ENSMUSG00000038204 AllianceGenome:MGI:2152836
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Asb-10
    Summary
    Predicted to be involved in intracellular signal transduction. Predicted to be located in cytoplasm and nucleus. Is expressed in limb and limb mesenchyme. Orthologous to human ASB10 (ankyrin repeat and SOCS box containing 10). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in heart adult (RPKM 42.5) and mammary gland adult (RPKM 4.3) See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 A3; 5 11.93 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (24737695..24745976, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (24532697..24540978, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 Neighboring gene VISTA enhancer mm1191 Neighboring gene gastrulation brain homeobox 1 Neighboring gene STARR-positive B cell enhancer mm9_chr5:24035915-24036216 Neighboring gene IQ motif containing with AAA domain 1 like Neighboring gene STARR-positive B cell enhancer ABC_E6314 Neighboring gene ATP-binding cassette, sub-family F member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Functional analysis of Asb-1 using genetic modification in mice. Kile BT, et al. Mol Cell Biol, 2001 Sep. PMID 11509662, Free PMC Article
    2. Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. Sundberg JP, et al. PLoS One, 2017. PMID 28700664, Free PMC Article
    3. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    4. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat and SOCS box protein 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310476.1 → NP_001297405.1  ankyrin repeat and SOCS box protein 10 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC116136, AK028538, AK052929
      Consensus CDS
      CCDS80229.1
      UniProtKB/TrEMBL
      D3YU18
      Related
      ENSMUSP00000112743.2, ENSMUST00000117900.8
      Conserved Domains (5) summary
      cd00204
      Location:103 → 220
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03587
      Location:406 → 445
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
      pfam12796
      Location:137 → 230
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:102 → 153
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:133 → 163
      ANK; ANK repeat [structural motif]

    2. NM_080444.5 → NP_536692.1  ankyrin repeat and SOCS box protein 10 isoform 1

      See identical proteins and their annotated locations for NP_536692.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC116136, AK028538, AK052929
      Consensus CDS
      CCDS19124.1
      UniProtKB/Swiss-Prot
      B2RUP6, Q91ZT7
      UniProtKB/TrEMBL
      D3Z651
      Related
      ENSMUSP00000041539.7, ENSMUST00000048302.13
      Conserved Domains (5) summary
      cd00204
      Location:118 → 235
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03587
      Location:421 → 460
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
      pfam12796
      Location:152 → 245
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:117 → 168
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:148 → 178
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      24737695..24745976 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91ZT7.1 GenPept UniProtKB/Swiss-Prot:Q91ZT7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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