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    Slamf7 SLAM family member 7 [ Mus musculus (house mouse) ]

    Gene ID: 75345, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Slamf7provided by MGI
    Official Full Name
    SLAM family member 7provided by MGI
    Primary source
    MGI:MGI:1922595
    See related
    Ensembl:ENSMUSG00000038179 AllianceGenome:MGI:1922595
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    19A; CS1; 19A24; CRACC; 4930560D03Rik
    Summary
    Predicted to enable identical protein binding activity. Acts upstream of or within regulation of natural killer cell activation. Located in external side of plasma membrane. Orthologous to human SLAMF7 (SLAM family member 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 3.6), spleen adult (RPKM 2.3) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 H3; 1 79.54 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (171458506..171480522, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (171632403..171653037, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03041 Neighboring gene predicted gene, 35200 Neighboring gene CD244 molecule A Neighboring gene STARR-positive B cell enhancer ABC_E5848 Neighboring gene lymphocyte antigen 9 Neighboring gene STARR-positive B cell enhancer ABC_E5849 Neighboring gene STARR-positive B cell enhancer ABC_E800 Neighboring gene microRNA 7683 Neighboring gene STARR-positive B cell enhancer ABC_E11696 Neighboring gene STARR-positive B cell enhancer ABC_E2586 Neighboring gene CD48 antigen Neighboring gene translational machinery associated 7 homolog (S. cerevisiae), pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SLAMF7 regulates the inflammatory response in macrophages during polymicrobial sepsis. Wu Y, et al. J Clin Invest, 2023 Mar 15. PMID 36749634, Free PMC Article
    2. Signaling Lymphocytic Activation Molecule Family-7 Alleviates Corneal Inflammation by Promoting M2 Polarization. Zhu S, et al. J Infect Dis, 2021 Mar 3. PMID 32702113
    3. CRACC-CRACC interaction between Kupffer and NK cells contributes to poly I:C/D-GalN induced hepatitis. Li Y, et al. PLoS One, 2013. PMID 24098802, Free PMC Article
    4. SLAMF7 modulates B cells and adaptive immunity to regulate susceptibility to CNS autoimmunity. O'Connell P, et al. J Neuroinflammation, 2022 Oct 3. PMID 36199066, Free PMC Article
    5. SLAMF7 and IL-6R define distinct cytotoxic versus helper memory CD8(+) T cells. Loyal L, et al. Nat Commun, 2020 Dec 11. PMID 33311473, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SLAMF7 regulates the inflammatory response in macrophages during polymicrobial sepsis.
      Title: SLAMF7 regulates the inflammatory response in macrophages during polymicrobial sepsis.
    2. SLAMF7 modulates B cells and adaptive immunity to regulate susceptibility to CNS autoimmunity.
      Title: SLAMF7 modulates B cells and adaptive immunity to regulate susceptibility to CNS autoimmunity.
    3. Signaling Lymphocytic Activation Molecule Family-7 Alleviates Corneal Inflammation by Promoting M2 Polarization.
      Title: Signaling Lymphocytic Activation Molecule Family-7 Alleviates Corneal Inflammation by Promoting M2 Polarization.
    4. SLAMF7 Signaling Reprograms T Cells toward Exhaustion in the Tumor Microenvironment.
      Title: SLAMF7 Signaling Reprograms T Cells toward Exhaustion in the Tumor Microenvironment.
    5. SLAMF7 and IL-6R define distinct cytotoxic versus helper memory CD8(+) T cells.
      Title: SLAMF7 and IL-6R define distinct cytotoxic versus helper memory CD8(+) T cells.
    6. phagocytosis of haematopoietic tumour cells during SIRPalpha-CD47 blockade was strictly dependent on SLAM family receptors in vitro and in vivo; in both mouse and human cells, this function required a single SLAM family member, SLAMF7 (also known as CRACC, CS1, CD319), expressed on macrophages and tumour cell targets
      Title: SLAMF7 is critical for phagocytosis of haematopoietic tumour cells via Mac-1 integrin.
    7. CRACC-CRACC interaction between Kupffer and NK cells contributes to poly I:C/D-GalN induced hepatitis.
      Title: CRACC-CRACC interaction between Kupffer and NK cells contributes to poly I:C/D-GalN induced hepatitis.
    8. CRACC was a critical positive regulator of NK cell function mediated by EAT-2.
      Title: Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function.
    9. 2B4, NTB-A and CRACC have roles in the regulation of Natural Killer cell function [review]
      Title: Regulation of NK cell activity by 2B4, NTB-A and CRACC.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in T cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of natural killer cell activation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    SLAM family member 7
    Names
    leukocyte cell-surface antigen
    novel Ly9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347184.2 → NP_001334113.1  SLAM family member 7 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC083892, AC091521
      Consensus CDS
      CCDS83636.1
      UniProtKB/TrEMBL
      A0A0A6YW73, A0A0A6YWL9
      Related
      ENSMUSP00000141426.2, ENSMUST00000192024.6
      Conserved Domains (1) summary
      cl11960
      Location:31 → 122
      Ig; Immunoglobulin domain

    2. NM_001412826.1 → NP_001399755.1  SLAM family member 7 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC083892, AC091521
      UniProtKB/TrEMBL
      A0A0R4J2D8
      Related
      ENSMUSP00000106907.4, ENSMUST00000111276.9

    3. NM_144539.6 → NP_653122.2  SLAM family member 7 isoform 1 precursor

      See identical proteins and their annotated locations for NP_653122.2

      Status: VALIDATED

      Source sequence(s)
      AC083892, AC091521
      Consensus CDS
      CCDS15500.1
      UniProtKB/Swiss-Prot
      Q8BHK6, Q8BTL2, Q8CJ63, Q8CJ64, Q8CJ65, Q91XA0
      UniProtKB/TrEMBL
      A0A0R4J2D8
      Related
      ENSMUSP00000141871.2, ENSMUST00000192195.6
      Conserved Domains (1) summary
      cl11960
      Location:31 → 122
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      171458506..171480522 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011238876.4 → XP_011237178.1  SLAM family member 7 isoform X2

      See identical proteins and their annotated locations for XP_011237178.1

      UniProtKB/Swiss-Prot
      Q8BHK6, Q8BTL2, Q8CJ63, Q8CJ64, Q8CJ65, Q91XA0
      UniProtKB/TrEMBL
      A0A0R4J2D8
      Conserved Domains (1) summary
      cl11960
      Location:31 → 122
      Ig; Immunoglobulin domain

    2. XM_030243259.2 → XP_030099119.1  SLAM family member 7 isoform X3

      UniProtKB/TrEMBL
      A0A0A6YW73, A0A0A6YWL9
      Conserved Domains (1) summary
      cl11960
      Location:31 → 122
      Ig; Immunoglobulin domain

    3. XM_036154079.1 → XP_036009972.1  SLAM family member 7 isoform X4

      UniProtKB/TrEMBL
      Q18PI2
      Conserved Domains (2) summary
      cd00096
      Location:16 → 21
      Ig; Ig strand D [structural motif]
      cl11960
      Location:7 → 61
      Ig; Immunoglobulin domain

    4. XM_036154066.1 → XP_036009959.1  SLAM family member 7 isoform X1

      UniProtKB/TrEMBL
      A0A0R4J2D6, Q18PI2
      Related
      ENSMUSP00000141259.2, ENSMUST00000194531.6
      Conserved Domains (2) summary
      cd00096
      Location:27 → 32
      Ig; Ig strand A [structural motif]
      cl11960
      Location:27 → 122
      Ig; Immunoglobulin domain

    5. XM_011238875.4 → XP_011237177.1  SLAM family member 7 isoform X1

      See identical proteins and their annotated locations for XP_011237177.1

      UniProtKB/TrEMBL
      A0A0R4J2D6, Q18PI2
      Conserved Domains (2) summary
      cd00096
      Location:27 → 32
      Ig; Ig strand A [structural motif]
      cl11960
      Location:27 → 122
      Ig; Immunoglobulin domain

    6. XM_011238874.4 → XP_011237176.2  SLAM family member 7 isoform X1

      UniProtKB/TrEMBL
      A0A0R4J2D6, Q18PI2
      Conserved Domains (2) summary
      cd00096
      Location:27 → 32
      Ig; Ig strand A [structural motif]
      cl11960
      Location:27 → 122
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BHK6.2 GenPept UniProtKB/Swiss-Prot:Q8BHK6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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