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    Rtkn2 rhotekin 2 [ Mus musculus (house mouse) ]

    Gene ID: 170799, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Rtkn2provided by MGI
    Official Full Name
    rhotekin 2provided by MGI
    Primary source
    MGI:MGI:2158417
    See related
    Ensembl:ENSMUSG00000037846 AllianceGenome:MGI:2158417
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mbf; Plekhk1; B130039D23Rik
    Summary
    Acts upstream of or within hemopoiesis and positive regulation of cell population proliferation. Located in plasma membrane. Is expressed in embryo and lung. Orthologous to human RTKN2 (rhotekin 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in lung adult (RPKM 8.1), CNS E11.5 (RPKM 1.4) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10 B5.1; 10 35.06 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (67815371..67894259)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (67979566..68058429)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_27009 Neighboring gene zinc finger protein 365 Neighboring gene STARR-seq mESC enhancer starr_27010 Neighboring gene RIKEN cDNA 4930521O17 gene Neighboring gene STARR-positive B cell enhancer ABC_E5144 Neighboring gene STARR-seq mESC enhancer starr_27014 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:67544592-67544803 Neighboring gene STARR-seq mESC enhancer starr_27016 Neighboring gene AT-rich interaction domain 5B Neighboring gene STARR-seq mESC enhancer starr_27019 Neighboring gene STARR-seq mESC enhancer starr_27023 Neighboring gene STARR-positive B cell enhancer ABC_E9344 Neighboring gene STARR-seq mESC enhancer starr_27025 Neighboring gene predicted gene, 51770 Neighboring gene STARR-seq mESC enhancer starr_27026 Neighboring gene STARR-positive B cell enhancer ABC_E8342 Neighboring gene STARR-positive B cell enhancer ABC_E3891 Neighboring gene STARR-positive B cell enhancer ABC_E5145 Neighboring gene STARR-seq mESC enhancer starr_27031 Neighboring gene STARR-seq mESC enhancer starr_27032 Neighboring gene STARR-seq mESC enhancer starr_27034 Neighboring gene STARR-positive B cell enhancer ABC_E10619 Neighboring gene STARR-positive B cell enhancer ABC_E8343 Neighboring gene STARR-positive B cell enhancer ABC_E10620 Neighboring gene STARR-seq mESC enhancer starr_27036 Neighboring gene STARR-seq mESC enhancer starr_27037 Neighboring gene RIKEN cDNA 4930545H06 gene Neighboring gene STARR-seq mESC enhancer starr_27038

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genetic approach and phenotype-based complementation screening for identification of stroma cell-derived proteins involved in cell proliferation. Tulin EE, et al. Exp Cell Res, 2002 Jan 1. PMID 11740862
    2. Genome-wide association of multiple complex traits in outbred mice by ultra-low-coverage sequencing. Nicod J, et al. Nat Genet, 2016 Aug. PMID 27376238, Free PMC Article
    3. Differential chromatin binding of the lung lineage transcription factor NKX2-1 resolves opposing murine alveolar cell fates in vivo. Little DR, et al. Nat Commun, 2021 May 4. PMID 33947861, Free PMC Article
    4. WNT5a-ROR Signaling Is Essential for Alveologenesis. Li C, et al. Cells, 2020 Feb 7. PMID 32046118, Free PMC Article
    5. CIN85 interacting proteins in B cells-specific role for SHIP-1. Büchse T, et al. Mol Cell Proteomics, 2011 Oct. PMID 21725061, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC189880

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in hemopoiesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within hemopoiesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rhotekin-2
    Names
    PH domain-containing family K member 1
    membrane bound factor
    pleckstrin homology domain containing, family K member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359318.1 → NP_001346247.1  rhotekin-2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC160409, AK030986, AK052662, AK087239, AV026520
      Consensus CDS
      CCDS88018.1
      UniProtKB/Swiss-Prot
      Q14B46, Q8BFP3, Q8BFP8, Q8BFQ0
      UniProtKB/TrEMBL
      E9QP76
      Related
      ENSMUSP00000112946.2, ENSMUST00000118160.8
      Conserved Domains (3) summary
      smart00742
      Location:12 → 67
      Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
      cd13249
      Location:282 → 390
      PH_rhotekin2; Anillin Pleckstrin homology (PH) domain
      pfam08174
      Location:94 → 239
      Anillin; Cell division protein anillin

    2. NM_001359319.1 → NP_001346248.1  rhotekin-2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC160409, AK030986, AK045134, AK052662, AK087239, AV026520
      Consensus CDS
      CCDS88017.1
      UniProtKB/TrEMBL
      E9QP76
      Related
      ENSMUSP00000112419.2, ENSMUST00000117086.2
      Conserved Domains (3) summary
      smart00742
      Location:12 → 67
      Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
      cd13249
      Location:279 → 387
      PH_rhotekin2; Anillin Pleckstrin homology (PH) domain
      pfam08174
      Location:91 → 236
      Anillin; Cell division protein anillin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      67815371..67894259
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155654.1 → XP_036011547.1  rhotekin-2 isoform X2

      Conserved Domains (1) summary
      cd13249
      Location:4 → 112
      PH_rhotekin2; Anillin Pleckstrin homology (PH) domain

    2. XM_006513292.5 → XP_006513355.1  rhotekin-2 isoform X1

      Conserved Domains (1) summary
      cd13249
      Location:62 → 170
      PH_rhotekin2; Anillin Pleckstrin homology (PH) domain

    RNA

    1. XR_003948599.2 RNA Sequence

    2. XR_004936111.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001081346.1: Suppressed sequence

      Description
      NM_001081346.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.

    2. NM_133244.2: Suppressed sequence

      Description
      NM_133244.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14B46.2 GenPept UniProtKB/Swiss-Prot:Q14B46

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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