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    Smim14 small integral membrane protein 14 [ Mus musculus (house mouse) ]

    Gene ID: 68552, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Smim14provided by MGI
    Official Full Name
    small integral membrane protein 14provided by MGI
    Primary source
    MGI:MGI:1915802
    See related
    Ensembl:ENSMUSG00000037822 AllianceGenome:MGI:1915802
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MAd4; 1110003E01Rik; 1700127H04Rik; 5430439C17Rik
    Summary
    Acts upstream of or within blastocyst hatching. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including bone; central nervous system; definitive endoderm; early conceptus; and secondary oocyte. Orthologous to human SMIM14 (small integral membrane protein 14). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 25.8), genital fat pad adult (RPKM 20.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 C3.1; 5 33.69 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (65604187..65694492, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (65446844..65537149, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3577 Neighboring gene VISTA enhancer mm1569 Neighboring gene lipoic acid synthetase Neighboring gene STARR-seq mESC enhancer starr_13263 Neighboring gene STARR-positive B cell enhancer ABC_E4757 Neighboring gene UDP-glucose dehydrogenase Neighboring gene STARR-positive B cell enhancer ABC_E4758 Neighboring gene STARR-seq mESC enhancer starr_13264 Neighboring gene STARR-positive B cell enhancer ABC_E4759 Neighboring gene STARR-positive B cell enhancer ABC_E8059 Neighboring gene STARR-positive B cell enhancer ABC_E11290 Neighboring gene predicted gene, 40309 Neighboring gene ubiquitin-conjugating enzyme E2K Neighboring gene PDS5 cohesin associated factor A Neighboring gene predicted gene, 24399

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification and functional analysis of novel genes expressed in the Anterior Visceral Endoderm. Gonçalves L, et al. Int J Dev Biol, 2011. PMID 21553379
    2. Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. Cui W, et al. Sci Rep, 2016 Nov 21. PMID 27869233, Free PMC Article
    3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC7185

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blastocyst hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    small integral membrane protein 14

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001376971.1 → NP_001363900.1  small integral membrane protein 14

      Status: VALIDATED

      Source sequence(s)
      AC136513
      UniProtKB/Swiss-Prot
      Q91VT8
      UniProtKB/TrEMBL
      F8WHW8
      Conserved Domains (1) summary
      pfam11027
      Location:3 → 97
      DUF2615; Protein of unknown function (DUF2615)

    2. NM_001376972.1 → NP_001363901.1  small integral membrane protein 14

      Status: VALIDATED

      Source sequence(s)
      AC136513
      UniProtKB/Swiss-Prot
      Q91VT8
      UniProtKB/TrEMBL
      F8WHW8
      Conserved Domains (1) summary
      pfam11027
      Location:3 → 97
      DUF2615; Protein of unknown function (DUF2615)

    3. NM_001376973.1 → NP_001363902.1  small integral membrane protein 14

      Status: VALIDATED

      Source sequence(s)
      AC136513
      UniProtKB/Swiss-Prot
      Q91VT8
      UniProtKB/TrEMBL
      F8WHW8
      Related
      ENSMUSP00000113456.2, ENSMUST00000121661.8
      Conserved Domains (1) summary
      pfam11027
      Location:3 → 97
      DUF2615; Protein of unknown function (DUF2615)

    4. NM_001376974.1 → NP_001363903.1  small integral membrane protein 14

      Status: VALIDATED

      Source sequence(s)
      AC136513
      UniProtKB/Swiss-Prot
      Q91VT8
      UniProtKB/TrEMBL
      F8WHW8
      Conserved Domains (1) summary
      pfam11027
      Location:3 → 97
      DUF2615; Protein of unknown function (DUF2615)

    5. NM_001376975.1 → NP_001363904.1  small integral membrane protein 14

      Status: VALIDATED

      Source sequence(s)
      AC136513
      UniProtKB/Swiss-Prot
      Q91VT8
      UniProtKB/TrEMBL
      F8WHW8
      Conserved Domains (1) summary
      pfam11027
      Location:3 → 97
      DUF2615; Protein of unknown function (DUF2615)

    6. NM_001376976.1 → NP_001363905.1  small integral membrane protein 14

      Status: VALIDATED

      Source sequence(s)
      AC136513
      UniProtKB/Swiss-Prot
      Q91VT8
      UniProtKB/TrEMBL
      F8WHW8
      Conserved Domains (1) summary
      pfam11027
      Location:3 → 97
      DUF2615; Protein of unknown function (DUF2615)

    7. NM_001376977.1 → NP_001363906.1  small integral membrane protein 14

      Status: VALIDATED

      Source sequence(s)
      AC136513
      UniProtKB/Swiss-Prot
      Q91VT8
      UniProtKB/TrEMBL
      F8WHW8
      Conserved Domains (1) summary
      pfam11027
      Location:3 → 97
      DUF2615; Protein of unknown function (DUF2615)

    8. NM_001376978.1 → NP_001363907.1  small integral membrane protein 14

      Status: VALIDATED

      Source sequence(s)
      AC136513
      UniProtKB/Swiss-Prot
      Q91VT8
      UniProtKB/TrEMBL
      F8WHW8
      Conserved Domains (1) summary
      pfam11027
      Location:3 → 97
      DUF2615; Protein of unknown function (DUF2615)

    9. NM_001376979.1 → NP_001363908.1  small integral membrane protein 14

      Status: VALIDATED

      Source sequence(s)
      AC136513
      UniProtKB/Swiss-Prot
      Q91VT8
      UniProtKB/TrEMBL
      F8WHW8
      Conserved Domains (1) summary
      pfam11027
      Location:3 → 97
      DUF2615; Protein of unknown function (DUF2615)

    10. NM_133697.4 → NP_598458.1  small integral membrane protein 14

      See identical proteins and their annotated locations for NP_598458.1

      Status: VALIDATED

      Source sequence(s)
      AC136513, AK164394, CJ052807
      Consensus CDS
      CCDS19309.1
      UniProtKB/Swiss-Prot
      Q91VT8
      UniProtKB/TrEMBL
      F8WHW8
      Related
      ENSMUSP00000122363.2, ENSMUST00000139122.8
      Conserved Domains (1) summary
      pfam11027
      Location:3 → 97
      DUF2615; Protein of unknown function (DUF2615)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      65604187..65694492 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165458.1 → XP_036021351.1  small integral membrane protein 14 isoform X1

      UniProtKB/Swiss-Prot
      Q91VT8
      UniProtKB/TrEMBL
      F8WHW8
      Conserved Domains (1) summary
      pfam11027
      Location:3 → 97
      DUF2615; Protein of unknown function (DUF2615)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91VT8.1 GenPept UniProtKB/Swiss-Prot:Q91VT8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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