Ephx3 epoxide hydrolase 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ephx3provided by MGI
Official Full Name: epoxide hydrolase 3provided by MGI
Primary source: MGI:MGI:1919182
See related: Ensembl:ENSMUSG00000037577 AllianceGenome:MGI:1919182
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: EH3; Abhd9; 2310063B19Rik
Summary: Predicted to enable epoxide hydrolase activity. Predicted to be involved in epoxide metabolic process. Predicted to act upstream of or within lipid metabolic process. Predicted to be located in membrane. Predicted to be active in intracellular membrane-bounded organelle. Orthologous to human EPHX3 (epoxide hydrolase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in stomach adult (RPKM 8.4), lung adult (RPKM 2.9) and 6 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 17 B1; 17 17.39 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (32402742..32408444, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (32183770..32189470, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Epoxide hydrolase 3 (Ephx3) gene disruption reduces ceramide linoleate epoxide hydrolysis and impairs skin barrier function.
Title: Epoxide hydrolase 3 (Ephx3) gene disruption reduces ceramide linoleate epoxide hydrolysis and impairs skin barrier function.
Generation and characterization of epoxide hydrolase 3 (EPHX3)-deficient mice
Title: Generation and characterization of epoxide hydrolase 3 (EPHX3)-deficient mice.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

General gene information

Go to the top of the page Help

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables epoxide hydrolase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in epoxide metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: epoxide hydrolase 3

Names: abhydrolase domain-containing protein 9

NP_001028335.1

EC 3.3.2.10

NP_001334270.1

EC 3.3.2.10

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033163.4 → NP_001028335.1 epoxide hydrolase 3 isoform 1

See identical proteins and their annotated locations for NP_001028335.1

Status: VALIDATED

Source sequence(s)

CT033755

Consensus CDS

CCDS28615.1

UniProtKB/TrEMBL

A0A0R4J127, A6H695

Related

ENSMUSP00000085013.4, ENSMUST00000087721.10

Conserved Domains (2) summary

COG0596
Location:144 → 415

MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

cl21494
Location:139 → 262

Abhydrolase; alpha/beta hydrolases
NM_001347341.2 → NP_001334270.1 epoxide hydrolase 3 isoform 2

Status: VALIDATED

Source sequence(s)

CT033755

Consensus CDS

CCDS84290.1

UniProtKB/TrEMBL

A6H695, G3XA19

Related

ENSMUSP00000124600.2, ENSMUST00000162117.3