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    Itih2 inter-alpha trypsin inhibitor, heavy chain 2 [ Mus musculus (house mouse) ]

    Gene ID: 16425, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Itih2provided by MGI
    Official Full Name
    inter-alpha trypsin inhibitor, heavy chain 2provided by MGI
    Primary source
    MGI:MGI:96619
    See related
    Ensembl:ENSMUSG00000037254 AllianceGenome:MGI:96619
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Intin2; Itih-2; ITI-HC2
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in hyaluronan metabolic process. Predicted to act upstream of or within negative regulation of peptidase activity. Located in collagen-containing extracellular matrix. Is expressed in germ cell of testis; gut; liver; and meninges. Orthologous to human ITIH2 (inter-alpha-trypsin inhibitor heavy chain 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver E18 (RPKM 372.8), liver E14 (RPKM 211.7) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 A1; 2 6.89 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (10099408..10135492, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (10094591..10130683, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ATP synthase F1 subunit gamma Neighboring gene predicted gene, 23608 Neighboring gene Kin17 DNA and RNA binding protein Neighboring gene inter-alpha-trypsin inhibitor, heavy chain 5 Neighboring gene STARR-seq mESC enhancer starr_03643 Neighboring gene predicted gene, 31496

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The three heavy-chain precursors for the inter-alpha-inhibitor family in mouse: new members of the multicopper oxidase protein group with differential transcription in liver and brain. Chan P, et al. Biochem J, 1995 Mar 1. PMID 7534067, Free PMC Article
    2. The genes for the inter-alpha-inhibitor family share a homologous organization in human and mouse. Salier JP, et al. Mamm Genome, 1992. PMID 1371941
    3. Homologous chromosomal locations of the four genes for inter-alpha-inhibitor and pre-alpha-inhibitor family in human and mouse: assignment of the ancestral gene for the lipocalin superfamily. Salier JP, et al. Genomics, 1992 Sep. PMID 1385302
    4. Developmentally regulated transcription of the four liver-specific genes for inter-alpha-inhibitor family in mouse. Salier JP, et al. Biochem J, 1993 Nov 15. PMID 7504460, Free PMC Article
    5. Spermatogonia-dependent expression of testicular genes in mice. Tanaka K, et al. Dev Biol, 2002 Jun 15. PMID 12051830

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hyaluronic acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in hyaluronan metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    inter-alpha-trypsin inhibitor heavy chain H2
    Names
    ITI heavy chain H2
    inter-alpha-inhibitor heavy chain 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010582.4 → NP_034712.3  inter-alpha-trypsin inhibitor heavy chain H2 precursor

      Status: VALIDATED

      Source sequence(s)
      AL772367
      Consensus CDS
      CCDS15677.2
      UniProtKB/Swiss-Prot
      A2AKU6, Q3UZM0, Q61703
      Related
      ENSMUSP00000046530.9, ENSMUST00000042290.14
      Conserved Domains (3) summary
      smart00609
      Location:56 → 185
      VIT; Vault protein Inter-alpha-Trypsin domain
      cd01461
      Location:307 → 488
      vWA_interalpha_trypsin_inhibitor; vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to ...
      pfam06668
      Location:735 → 921
      ITI_HC_C; Inter-alpha-trypsin inhibitor heavy chain C-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      10099408..10135492 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61703.1 GenPept UniProtKB/Swiss-Prot:Q61703

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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