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    Trim17 tripartite motif-containing 17 [ Mus musculus (house mouse) ]

    Gene ID: 56631, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Trim17provided by MGI
    Official Full Name
    tripartite motif-containing 17provided by MGI
    Primary source
    MGI:MGI:1861440
    See related
    Ensembl:ENSMUSG00000036964 AllianceGenome:MGI:1861440
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    terf; Rnf16
    Summary
    Predicted to enable protein-macromolecule adaptor activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including autophagy; innate immune response; and protein autoubiquitination. Predicted to be active in cytoplasm. Orthologous to human TRIM17 (tripartite motif containing 17). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 63.4), whole brain E14.5 (RPKM 20.0) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 B1.3; 11 36.38 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (58845511..58863923)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (58954671..58973075)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3954 Neighboring gene STARR-positive B cell enhancer ABC_E114 Neighboring gene predicted gene, 51864 Neighboring gene STARR-positive B cell enhancer ABC_E5230 Neighboring gene STARR-positive B cell enhancer ABC_E6989 Neighboring gene RIKEN cDNA 2310058D17 gene Neighboring gene H2B clustered histone 27 Neighboring gene H2B clustered histone 26 Neighboring gene H2A clustered histone 25 Neighboring gene STARR-seq mESC enhancer starr_29613 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:58796334-58796535 Neighboring gene H3.4 histone, cluster member Neighboring gene tripartite motif-containing 11 Neighboring gene obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF Neighboring gene predicted gene 10435

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Trim17, a novel E3 ubiquitin-ligase, initiates neuronal apoptosis. Lassot I, et al. Cell Death Differ, 2010 Dec. PMID 20559321, Free PMC Article
    2. Chromosome mapping of RNF16 and rnf16, human, mouse and rat genes coding for testis RING finger protein (terf), a member of the RING finger family. Ogawa S, et al. Cytogenet Cell Genet, 2000. PMID 10894938
    3. Control of neuronal apoptosis by reciprocal regulation of NFATc3 and Trim17. Mojsa B, et al. Cell Death Differ, 2015 Feb. PMID 25215946, Free PMC Article
    4. TRIM44 interacts with and stabilizes terf, a TRIM ubiquitin E3 ligase. Urano T, et al. Biochem Biophys Res Commun, 2009 May 29. PMID 19358823
    5. Trim17-mediated ubiquitination and degradation of Mcl-1 initiate apoptosis in neurons. Magiera MM, et al. Cell Death Differ, 2013 Feb. PMID 22976837, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NFATc3 interacted in a SUMO-dependent manner with Trim17, an E3 ubiquitin ligase necessary for neuronal apoptosis
      Title: Control of neuronal apoptosis by reciprocal regulation of NFATc3 and Trim17.
    2. Trim17 contributes to the ubiquitination and the proteasomal degradation of Mcl-1 in neurons.
      Title: Trim17-mediated ubiquitination and degradation of Mcl-1 initiate apoptosis in neurons.
    3. Overexpression and silencing data indicate that Trim17 is necessary and sufficient for inducing the Bax-dependent intrinsic pathway of neuronal apoptosis and that its pro-apoptotic effect depends on its E3 activity.
      Title: Trim17, a novel E3 ubiquitin-ligase, initiates neuronal apoptosis.
    4. terf interacts with TRIM44;TRIM44 inhibited ubiquitination of terf, and thus stabilized the protein.
      Title: TRIM44 interacts with and stabilizes terf, a TRIM ubiquitin E3 ligase.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase TRIM17
    Names
    RING-type E3 ubiquitin transferase TRIM17
    ring finger protein 16
    tripartite motif protein 17
    tripartite motif protein TRIM17
    tripartite motif-containing protein 17
    NP_112449.1
    XP_006533874.1
    XP_006533875.1
    XP_011247459.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031172.3 → NP_112449.1  E3 ubiquitin-protein ligase TRIM17

      See identical proteins and their annotated locations for NP_112449.1

      Status: VALIDATED

      Source sequence(s)
      AL662809, BC055112
      Consensus CDS
      CCDS24756.1
      UniProtKB/Swiss-Prot
      A2AB82, Q7TPM3, Q99PP8
      Related
      ENSMUSP00000074639.7, ENSMUST00000075141.7
      Conserved Domains (4) summary
      PTZ00121
      Location:64 → 271
      PTZ00121; MAEBL; Provisional
      cd15812
      Location:296 → 472
      SPRY_PRY_TRIM17; PRY/SPRY domain of tripartite motif-binding protein 17 (TRIM17), also known as testis RING finger protein (terf)
      cd19762
      Location:98 → 139
      Bbox2_TRIM7-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins TRIM7, TRIM27 and similar proteins
      cl17238
      Location:13 → 66
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      58845511..58863923
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249157.4 → XP_011247459.1  E3 ubiquitin-protein ligase TRIM17 isoform X1

      See identical proteins and their annotated locations for XP_011247459.1

      UniProtKB/Swiss-Prot
      A2AB82, Q7TPM3, Q99PP8
      Conserved Domains (4) summary
      PTZ00121
      Location:64 → 271
      PTZ00121; MAEBL; Provisional
      cd15812
      Location:296 → 472
      SPRY_PRY_TRIM17; PRY/SPRY domain of tripartite motif-binding protein 17 (TRIM17), also known as testis RING finger protein (terf)
      cd19762
      Location:98 → 139
      Bbox2_TRIM7-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins TRIM7, TRIM27 and similar proteins
      cl17238
      Location:13 → 66
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    2. XM_006533811.4 → XP_006533874.1  E3 ubiquitin-protein ligase TRIM17 isoform X1

      See identical proteins and their annotated locations for XP_006533874.1

      UniProtKB/Swiss-Prot
      A2AB82, Q7TPM3, Q99PP8
      Conserved Domains (4) summary
      PTZ00121
      Location:64 → 271
      PTZ00121; MAEBL; Provisional
      cd15812
      Location:296 → 472
      SPRY_PRY_TRIM17; PRY/SPRY domain of tripartite motif-binding protein 17 (TRIM17), also known as testis RING finger protein (terf)
      cd19762
      Location:98 → 139
      Bbox2_TRIM7-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins TRIM7, TRIM27 and similar proteins
      cl17238
      Location:13 → 66
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    3. XM_006533812.5 → XP_006533875.1  E3 ubiquitin-protein ligase TRIM17 isoform X1

      See identical proteins and their annotated locations for XP_006533875.1

      UniProtKB/Swiss-Prot
      A2AB82, Q7TPM3, Q99PP8
      Conserved Domains (4) summary
      PTZ00121
      Location:64 → 271
      PTZ00121; MAEBL; Provisional
      cd15812
      Location:296 → 472
      SPRY_PRY_TRIM17; PRY/SPRY domain of tripartite motif-binding protein 17 (TRIM17), also known as testis RING finger protein (terf)
      cd19762
      Location:98 → 139
      Bbox2_TRIM7-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins TRIM7, TRIM27 and similar proteins
      cl17238
      Location:13 → 66
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TPM3.1 GenPept UniProtKB/Swiss-Prot:Q7TPM3

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