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    Ssx2ip SSX family member 2 interacting protein [ Mus musculus (house mouse) ]

    Gene ID: 99167, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Ssx2ipprovided by MGI
    Official Full Name
    SSX family member 2 interacting proteinprovided by MGI
    Primary source
    MGI:MGI:2139150
    See related
    Ensembl:ENSMUSG00000036825 AllianceGenome:MGI:2139150
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Adip
    Summary
    Predicted to enable protein domain specific binding activity. Acts upstream of or within regulation of Rac protein signal transduction and regulation of cell motility. Located in cell leading edge; centriolar satellite; and ciliary basal body. Orthologous to human SSX2IP (SSX family member 2 interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 30.6), liver E14 (RPKM 23.9) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    3 H2; 3 71.03 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (146110397..146145899)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (146404642..146440144)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene 10636 Neighboring gene STARR-seq mESC enhancer starr_09222 Neighboring gene predicted gene, 22078 Neighboring gene STARR-positive B cell enhancer ABC_E9230 Neighboring gene chitobiase Neighboring gene spermatogenesis associated 1 Neighboring gene STARR-positive B cell enhancer ABC_E6144 Neighboring gene G protein subunit gamma 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. WDR8 is a centriolar satellite and centriole-associated protein that promotes ciliary vesicle docking during ciliogenesis. Kurtulmus B, et al. J Cell Sci, 2016 Feb 1. PMID 26675238
    2. OCRL regulates lysosome positioning and mTORC1 activity through SSX2IP-mediated microtubule anchoring. Wang B, et al. EMBO Rep, 2021 Jul 5. PMID 33987909, Free PMC Article
    3. Afadin- and alpha-actinin-binding protein ADIP directly binds beta'-COP, a subunit of the coatomer complex. Asada M, et al. Biochem Biophys Res Commun, 2004 Aug 20. PMID 15358183
    4. The novel centriolar satellite protein SSX2IP targets Cep290 to the ciliary transition zone. Klinger M, et al. Mol Biol Cell, 2014 Feb. PMID 24356449, Free PMC Article
    5. ADIP, a novel Afadin- and alpha-actinin-binding protein localized at cell-cell adherens junctions. Asada M, et al. J Biol Chem, 2003 Feb 7. PMID 12446711

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. OCRL regulates lysosome positioning and mTORC1 activity through SSX2IP-mediated microtubule anchoring.
      Title: OCRL regulates lysosome positioning and mTORC1 activity through SSX2IP-mediated microtubule anchoring.
    2. The novel centriolar satellite protein SSX2IP targets Cep290 to the ciliary transition zone.
      Title: The novel centriolar satellite protein SSX2IP targets Cep290 to the ciliary transition zone.
    3. The results indicate that ADIP plays an essential role in PDGF-induced cell movement by interacting with afadin and Vav2 and regulating the activation of Rac.
      Title: Role of scaffold protein afadin dilute domain-interacting protein (ADIP) in platelet-derived growth factor-induced cell movement by activating Rac protein through Vav2 protein.
    4. localization at cell-cell adherens junctions
      Title: ADIP, a novel Afadin- and alpha-actinin-binding protein localized at cell-cell adherens junctions.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell projection organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in centrosome cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intraciliary transport involved in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intraciliary transport involved in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of Rac protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cell motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell leading edge IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in centriolar satellite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriolar satellite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    afadin- and alpha-actinin-binding protein
    Names
    SSX 2 interacting protein
    afadin DIL domain-interacting protein
    synovial sarcoma, X 2 interacting protein
    synovial sarcoma, X breakpoint 2 interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001253768.2 → NP_001240697.1  afadin- and alpha-actinin-binding protein isoform b

      See identical proteins and their annotated locations for NP_001240697.1

      Status: VALIDATED

      Source sequence(s)
      AC124987, AK049080, AK077112, AK173064, BE945817
      Consensus CDS
      CCDS57260.1
      UniProtKB/TrEMBL
      A0A0R4J1A9, Q69ZV4
      Related
      ENSMUSP00000101755.2, ENSMUST00000106149.8
      Conserved Domains (1) summary
      pfam11559
      Location:63 → 214
      ADIP; Afadin- and alpha -actinin-Binding

    2. NM_001253769.2 → NP_001240698.1  afadin- and alpha-actinin-binding protein isoform b

      See identical proteins and their annotated locations for NP_001240698.1

      Status: VALIDATED

      Source sequence(s)
      AC124987, AK043865, AK049080, AK173064, BE945817
      Consensus CDS
      CCDS57260.1
      UniProtKB/TrEMBL
      A0A0R4J1A9, Q69ZV4
      Related
      ENSMUSP00000101757.2, ENSMUST00000106151.8
      Conserved Domains (1) summary
      pfam11559
      Location:63 → 214
      ADIP; Afadin- and alpha -actinin-Binding

    3. NM_001253770.2 → NP_001240699.1  afadin- and alpha-actinin-binding protein isoform b

      See identical proteins and their annotated locations for NP_001240699.1

      Status: VALIDATED

      Source sequence(s)
      AC124987, AK031356, AK049080, AK173064, BE945817
      Consensus CDS
      CCDS57260.1
      UniProtKB/TrEMBL
      A0A0R4J1A9, Q69ZV4
      Related
      ENSMUSP00000045663.5, ENSMUST00000039021.11
      Conserved Domains (1) summary
      pfam11559
      Location:63 → 214
      ADIP; Afadin- and alpha -actinin-Binding

    4. NM_001355661.1 → NP_001342590.1  afadin- and alpha-actinin-binding protein isoform a

      Status: VALIDATED

      Source sequence(s)
      AC124987
      Consensus CDS
      CCDS38665.1
      UniProtKB/Swiss-Prot
      Q8BG59, Q8C7X0, Q8K2F7, Q8VC66
      UniProtKB/TrEMBL
      Q69ZV4
      Conserved Domains (2) summary
      pfam11559
      Location:63 → 214
      ADIP; Afadin- and alpha -actinin-Binding
      pfam17380
      Location:140 → 301
      DUF5401; Family of unknown function (DUF5401)

    5. NM_001411104.1 → NP_001398033.1  afadin- and alpha-actinin-binding protein isoform a

      Status: VALIDATED

      Source sequence(s)
      AC124987
      UniProtKB/Swiss-Prot
      Q8BG59, Q8C7X0, Q8K2F7, Q8VC66

    6. NM_001411105.1 → NP_001398034.1  afadin- and alpha-actinin-binding protein isoform a

      Status: VALIDATED

      Source sequence(s)
      AC124987
      UniProtKB/Swiss-Prot
      Q8BG59, Q8C7X0, Q8K2F7, Q8VC66

    7. NM_001411107.1 → NP_001398036.1  afadin- and alpha-actinin-binding protein isoform a

      Status: VALIDATED

      Source sequence(s)
      AC124987
      UniProtKB/Swiss-Prot
      Q8BG59, Q8C7X0, Q8K2F7, Q8VC66

    8. NM_001411108.1 → NP_001398037.1  afadin- and alpha-actinin-binding protein isoform a

      Status: VALIDATED

      Source sequence(s)
      AC124987
      UniProtKB/Swiss-Prot
      Q8BG59, Q8C7X0, Q8K2F7, Q8VC66

    9. NM_001411109.1 → NP_001398038.1  afadin- and alpha-actinin-binding protein isoform a

      Status: VALIDATED

      Source sequence(s)
      AC124987
      UniProtKB/Swiss-Prot
      Q8BG59, Q8C7X0, Q8K2F7, Q8VC66

    10. NM_001411110.1 → NP_001398039.1  afadin- and alpha-actinin-binding protein isoform b

      Status: VALIDATED

      Source sequence(s)
      AC124987
      UniProtKB/TrEMBL
      A0A0R4J1A9

    11. NM_001411114.1 → NP_001398043.1  afadin- and alpha-actinin-binding protein isoform b

      Status: VALIDATED

      Source sequence(s)
      AC124987
      UniProtKB/TrEMBL
      A0A0R4J1A9

    12. NM_001411115.1 → NP_001398044.1  afadin- and alpha-actinin-binding protein isoform b

      Status: VALIDATED

      Source sequence(s)
      AC124987
      UniProtKB/TrEMBL
      A0A0R4J1A9

    13. NM_001411116.1 → NP_001398045.1  afadin- and alpha-actinin-binding protein isoform c

      Status: VALIDATED

      Source sequence(s)
      AC124987

    14. NM_001411117.1 → NP_001398046.1  afadin- and alpha-actinin-binding protein isoform c

      Status: VALIDATED

      Source sequence(s)
      AC124987

    15. NM_001411118.1 → NP_001398047.1  afadin- and alpha-actinin-binding protein isoform c

      Status: VALIDATED

      Source sequence(s)
      AC124987

    16. NM_001411119.1 → NP_001398048.1  afadin- and alpha-actinin-binding protein isoform d

      Status: VALIDATED

      Source sequence(s)
      AC124987

    17. NM_001411120.1 → NP_001398049.1  afadin- and alpha-actinin-binding protein isoform d

      Status: VALIDATED

      Source sequence(s)
      AC124987

    18. NM_001411121.1 → NP_001398050.1  afadin- and alpha-actinin-binding protein isoform e

      Status: VALIDATED

      Source sequence(s)
      AC124987

    19. NM_138744.4 → NP_620083.1  afadin- and alpha-actinin-binding protein isoform a

      See identical proteins and their annotated locations for NP_620083.1

      Status: VALIDATED

      Source sequence(s)
      AC124987, AK049080, AK173064, BE945817
      Consensus CDS
      CCDS38665.1
      UniProtKB/Swiss-Prot
      Q8BG59, Q8C7X0, Q8K2F7, Q8VC66
      UniProtKB/TrEMBL
      Q69ZV4
      Related
      ENSMUSP00000101759.3, ENSMUST00000106153.9
      Conserved Domains (2) summary
      pfam11559
      Location:63 → 214
      ADIP; Afadin- and alpha -actinin-Binding
      pfam17380
      Location:140 → 301
      DUF5401; Family of unknown function (DUF5401)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      146110397..146145899
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VC66.1 GenPept UniProtKB/Swiss-Prot:Q8VC66

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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