Hif1an hypoxia-inducible factor 1, alpha subunit inhibitor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hif1anprovided by MGI
Official Full Name: hypoxia-inducible factor 1, alpha subunit inhibitorprovided by MGI
Primary source: MGI:MGI:2442345
See related: Ensembl:ENSMUSG00000036450 AllianceGenome:MGI:2442345
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FIH; FIH1; 2310046M24Rik; A830014H24Rik
Summary: Predicted to enable several functions, including 2-oxoglutarate-dependent dioxygenase activity; NF-kappaB binding activity; and transition metal ion binding activity. Predicted to be involved in several processes, including negative regulation of Notch signaling pathway; negative regulation of transcription from RNA polymerase II promoter in response to hypoxia; and protein hydroxylation. Predicted to be located in cytosol; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and skeletal muscle. Orthologous to human HIF1AN (hypoxia inducible factor 1 subunit alpha inhibitor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in heart adult (RPKM 12.4), CNS E11.5 (RPKM 11.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C3; 19 37.98 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (44551293..44564713)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (44562854..44576274)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deficiency of factor-inhibiting HIF creates a tumor-promoting immune microenvironment.
Title: Deficiency of factor-inhibiting HIF creates a tumor-promoting immune microenvironment.
The Deubiquitinase OTUB1 Is a Key Regulator of Energy Metabolism.
Title: The Deubiquitinase OTUB1 Is a Key Regulator of Energy Metabolism.
Knockout of Factor-Inhibiting HIF (Hif1an) in Colon Epithelium Attenuates Chronic Colitis but Does Not Reduce Colorectal Cancer in Mice.
Title: Knockout of Factor-Inhibiting HIF (Hif1an) in Colon Epithelium Attenuates Chronic Colitis but Does Not Reduce Colorectal Cancer in Mice.
FIH-1-modulated HIF-1alpha C-TAD promotes acute kidney injury to chronic kidney disease progression via regulating KLF5 signaling.
Title: FIH-1-modulated HIF-1α C-TAD promotes acute kidney injury to chronic kidney disease progression via regulating KLF5 signaling.
MicroRNA-1-3p enhances osteoblast differentiation of MC3T3-E1 cells by interacting with hypoxia-inducible factor 1 alpha inhibitor (HIF1AN).
Title: MicroRNA-1-3p enhances osteoblast differentiation of MC3T3-E1 cells by interacting with hypoxia-inducible factor 1 α inhibitor (HIF1AN).
miR212 promotes renal interstitial fibrosis by inhibiting hypoxiainducible factor 1alpha inhibitor.
Title: miR‑212 promotes renal interstitial fibrosis by inhibiting hypoxia‑inducible factor 1‑α inhibitor.
HIF1AN was confirmed as a direct target of miR-135-5p. [miR-135-5p]
Title: MiR-135-5p promotes osteoblast differentiation by targeting HIF1AN in MC3T3-E1 cells.
FIH-1 has a role in disrupting the LRRK1/EGFR complex to positively regulate keratinocyte migration
Title: FIH-1 disrupts an LRRK1/EGFR complex to positively regulate keratinocyte migration.
miR-31/FIH1 pathway associates with liver fibrosis, perhaps by participation in the TGF-beta/Smad3 signalling of hepatic stellate cells.
Title: The role of the miR-31/FIH1 pathway in TGF-β-induced liver fibrosis.
gankyrin binds to and sequester factor inhibiting hypoxia-inducible factor-1 (FIH-1), which results in decreased interaction between FIH-1 and hypoxia-inducible factor-1alpha (HIF-1alpha) and increased activity of HIF-1 to promote VEGF production.
Title: Overexpression of gankyrin in mouse hepatocytes induces hemangioma by suppressing factor inhibiting hypoxia-inducible factor-1 (FIH-1) and activating hypoxia-inducible factor-1.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (6)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Hif1an (e-PCR), detects polymorphism
- UniSTS:531397

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NF-kappaB binding	ISO Inferred from Sequence Orthology more info
enables Notch binding	ISO Inferred from Sequence Orthology more info
enables [protein]-asparagine 3-dioxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables [protein]-asparagine 3-dioxygenase activity	ISO Inferred from Sequence Orthology more info
enables ankyrin repeat binding	IBA Inferred from Biological aspect of Ancestor more info
enables ankyrin repeat binding	ISO Inferred from Sequence Orthology more info
enables carboxylic acid binding	ISO Inferred from Sequence Orthology more info
enables dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables ferrous iron binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables peptidyl-aspartic acid 3-dioxygenase activity	ISO Inferred from Sequence Orthology more info
enables peptidyl-histidine dioxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidyl-histidine dioxygenase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myoblast differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: hypoxia-inducible factor 1-alpha inhibitor

Names: hypoxia-inducible factor asparagine hydroxylase

NP_795932.2

EC 1.14.11.30

EC 1.14.11.n4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.