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    Sh3bp4 SH3-domain binding protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 98402, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Sh3bp4provided by MGI
    Official Full Name
    SH3-domain binding protein 4provided by MGI
    Primary source
    MGI:MGI:2138297
    See related
    Ensembl:ENSMUSG00000036206 AllianceGenome:MGI:2138297
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BOG25
    Summary
    Predicted to enable GDP-dissociation inhibitor activity; identical protein binding activity; and small GTPase binding activity. Predicted to be involved in several processes, including negative regulation of GTPase activity; negative regulation of TOR signaling; and protein localization to lysosome. Predicted to act upstream of or within endocytosis. Predicted to be located in clathrin-coated pit; cytoplasmic vesicle; and nucleus. Predicted to be active in cytoplasm. Is expressed in cerebral cortex marginal layer and olfactory cortex marginal layer. Orthologous to human SH3BP4 (SH3 domain binding protein 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in lung adult (RPKM 16.2), ovary adult (RPKM 14.6) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 D; 1 45.05 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (88998061..89082940)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (89070333..89155087)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34194 Neighboring gene RIKEN cDNA 1700067G17 gene Neighboring gene STARR-seq mESC enhancer starr_01654 Neighboring gene STARR-seq mESC enhancer starr_01655 Neighboring gene STARR-positive B cell enhancer ABC_E2002 Neighboring gene cytidine 5'-triphosphate synthase 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_01658 Neighboring gene predicted gene, 34331 Neighboring gene STARR-seq mESC enhancer starr_01661 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene RIKEN cDNA C030007H22 gene Neighboring gene predicted gene, 41913

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TTP at Ser245 phosphorylation by AKT is required for binding to 14-3-3. Chiba S, et al. J Biochem, 2009 Mar. PMID 19122209
    2. SH3BP4 Regulates Intestinal Stem Cells and Tumorigenesis by Modulating β-Catenin Nuclear Localization. Antas P, et al. Cell Rep, 2019 Feb 26. PMID 30811977, Free PMC Article
    3. SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling. Kim YM, et al. Mol Cell, 2012 Jun 29. PMID 22575674, Free PMC Article
    4. Accelerating functional gene discovery in osteoarthritis. Butterfield NC, et al. Nat Commun, 2021 Jan 20. PMID 33473114, Free PMC Article
    5. Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. Nakahara M, et al. Mamm Genome, 2013 Jun. PMID 23604909

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SH3BP4 is a negative regulator of the Rag GTPase complex and amino acid-dependent mTORC1 signaling
      Title: SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling.
    2. TTP Ser(245) is the principal target for the modulation of this protein via the AKT signalling cascade.
      Title: TTP at Ser245 phosphorylation by AKT is required for binding to 14-3-3.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GDP-dissociation inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to amino acid stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of catalytic activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    SH3 domain-binding protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001420833.1 → NP_001407762.1  SH3 domain-binding protein 4

      Status: VALIDATED

      Source sequence(s)
      AC126024, AC133168, AC153647
      UniProtKB/Swiss-Prot
      Q8BXV5, Q8BY95, Q8C007, Q921I6

    2. NM_001420834.1 → NP_001407763.1  SH3 domain-binding protein 4

      Status: VALIDATED

      Source sequence(s)
      AC126024, AC133168, AC153647
      UniProtKB/Swiss-Prot
      Q8BXV5, Q8BY95, Q8C007, Q921I6

    3. NM_001420835.1 → NP_001407764.1  SH3 domain-binding protein 4

      Status: VALIDATED

      Source sequence(s)
      AC126024, AC133168, AC153647
      UniProtKB/Swiss-Prot
      Q8BXV5, Q8BY95, Q8C007, Q921I6

    4. NM_133816.4 → NP_598577.1  SH3 domain-binding protein 4

      See identical proteins and their annotated locations for NP_598577.1

      Status: VALIDATED

      Source sequence(s)
      AC126024, AC133168, AC153647
      Consensus CDS
      CCDS15147.1
      UniProtKB/Swiss-Prot
      Q8BXV5, Q8BY95, Q8C007, Q921I6
      Related
      ENSMUSP00000067581.5, ENSMUST00000066279.11
      Conserved Domains (3) summary
      cd11757
      Location:59 → 110
      SH3_SH3BP4; Src Homology 3 domain of SH3 domain-binding protein 4
      pfam07653
      Location:657 → 721
      SH3_2; Variant SH3 domain
      cl02517
      Location:323 → 403
      ZU5; ZU5 domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      88998061..89082940
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243890.2 → XP_030099750.1  SH3 domain-binding protein 4 isoform X2

      Conserved Domains (2) summary
      pfam07653
      Location:557 → 621
      SH3_2; Variant SH3 domain
      cl02517
      Location:223 → 303
      ZU5; ZU5 domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q921I6.1 GenPept UniProtKB/Swiss-Prot:Q921I6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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