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    Slain2 SLAIN motif family, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 75991, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Slain2provided by MGI
    Official Full Name
    SLAIN motif family, member 2provided by MGI
    Primary source
    MGI:MGI:1923241
    See related
    Ensembl:ENSMUSG00000036087 AllianceGenome:MGI:1923241
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5033405K12Rik; 8030444K12Rik
    Summary
    Involved in cytoplasmic microtubule organization and regulation of microtubule polymerization. Predicted to be located in centrosome and cytosol. Predicted to colocalize with microtubule plus-end. Is expressed in several structures, including brain and liver lobe. Orthologous to human SLAIN2 (SLAIN motif family member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 52.4), heart adult (RPKM 16.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 C3.2; 5 38.44 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (73071705..73136184)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (72914362..72978841)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3582 Neighboring gene TXK tyrosine kinase Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:73152561-73152781 Neighboring gene tec protein tyrosine kinase Neighboring gene STARR-positive B cell enhancer ABC_E4762 Neighboring gene STARR-positive B cell enhancer ABC_E8061 Neighboring gene STARR-positive B cell enhancer ABC_E10324 Neighboring gene STARR-positive B cell enhancer ABC_E8821 Neighboring gene predicted gene, 54302 Neighboring gene predicted gene, 54289 Neighboring gene solute carrier family 10 (sodium/bile acid cotransporter family), member 4 Neighboring gene zygote arrest 1, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cardiac-specific elevations in thyroid hormone enhance contractility and prevent pressure overload-induced cardiac dysfunction. Trivieri MG, et al. Proc Natl Acad Sci U S A, 2006 Apr 11. PMID 16595628, Free PMC Article
    2. Microtubule plus-end tracking proteins SLAIN1/2 and ch-TOG promote axonal development. van der Vaart B, et al. J Neurosci, 2012 Oct 17. PMID 23077057, Free PMC Article
    3. SLAIN2 links microtubule plus end-tracking proteins and controls microtubule growth in interphase. van der Vaart B, et al. J Cell Biol, 2011 Jun 13. PMID 21646404, Free PMC Article
    4. An Alternative Splicing Program for Mouse Craniofacial Development. Hooper JE, et al. Front Physiol, 2020. PMID 33013468, Free PMC Article
    5. Methyltransferase-like 21e inhibits 26S proteasome activity to facilitate hypertrophy of type IIb myofibers. Wang C, et al. FASEB J, 2019 Aug. PMID 31162944, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Circ-Slain2 Alleviates Cartilage Degradation and Inflammation of TMJOA.
      Title: Circ-Slain2 Alleviates Cartilage Degradation and Inflammation of TMJOA.
    2. Slain2 attenuates brain injury following subarachnoid hemorrhage by controlling axonal microtubule structure in mice.
      Title: Slain2 attenuates brain injury following subarachnoid hemorrhage by controlling axonal microtubule structure in mice.
    3. SLAIN2 is expressed throughout development and is highly enriched in brain.
      Title: Microtubule plus-end tracking proteins SLAIN1/2 and ch-TOG promote axonal development.
    4. Results identify SLAIN2 as a key component of microtubule plus end interaction networks.
      Title: SLAIN2 links microtubule plus end-tracking proteins and controls microtubule growth in interphase.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1458, MGC47019

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic microtubule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic microtubule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytoplasmic microtubule organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule nucleation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of microtubule polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of microtubule polymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    colocalizes_with microtubule plus-end IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with microtubule plus-end ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    SLAIN motif-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113423.2 → NP_001106894.1  SLAIN motif-containing protein 2 isoform b

      See identical proteins and their annotated locations for NP_001106894.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant1. It encodes isoform b, which lacks an internal segment and is shorter, compared to isoform a.
      Source sequence(s)
      AK029260, BB618957, BC076573, BY423831, BY736933
      Consensus CDS
      CCDS51517.1
      UniProtKB/Swiss-Prot
      Q05DK1, Q3UJI9, Q6ZPQ5, Q8CI08
      Related
      ENSMUSP00000116528.2, ENSMUST00000144843.8
      Conserved Domains (1) summary
      pfam15301
      Location:130 → 581
      SLAIN; SLAIN motif-containing family

    2. NM_153567.3 → NP_705795.2  SLAIN motif-containing protein 2 isoform a

      See identical proteins and their annotated locations for NP_705795.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK029260, AK039970, BB618957, BC076573, BY423831, BY736933, CF534366, CF728452, CK619668
      Consensus CDS
      CCDS19335.2
      UniProtKB/Swiss-Prot
      Q8CI08
      Related
      ENSMUSP00000115871.2, ENSMUST00000143829.5
      Conserved Domains (1) summary
      pfam15301
      Location:130 → 607
      SLAIN; SLAIN motif-containing family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      73071705..73136184
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504171.3 → XP_006504234.1  SLAIN motif-containing protein 2 isoform X1

      Conserved Domains (1) summary
      pfam15301
      Location:1 → 466
      SLAIN; SLAIN motif-containing family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CI08.2 GenPept UniProtKB/Swiss-Prot:Q8CI08

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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