U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Caps2 calcyphosphine 2 [ Mus musculus (house mouse) ]

    Gene ID: 353025, updated on 5-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Caps2provided by MGI
    Official Full Name
    calcyphosphine 2provided by MGI
    Primary source
    MGI:MGI:2441980
    See related
    Ensembl:ENSMUSG00000035694 AllianceGenome:MGI:2441980
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D630005B03Rik
    Summary
    Predicted to enable calcium ion binding activity. Orthologous to human CAPS2 (calcyphosine 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 1.4), bladder adult (RPKM 0.1) and 9 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Caps2 in Genome Data Viewer
    Location:
    10 D2; 10 60.18 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (111999254..112052466)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (112163349..112216561)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr10:111542860-111543160 Neighboring gene GLI pathogenesis-related 1 like 2 Neighboring gene STARR-seq mESC enhancer starr_27896 Neighboring gene NSA2 ribosome biogenesis homolog pseudogene Neighboring gene GLI pathogenesis-related 1 like 3 Neighboring gene STARR-seq mESC enhancer starr_27897 Neighboring gene STARR-seq mESC enhancer starr_27898 Neighboring gene STARR-seq mESC enhancer starr_27899 Neighboring gene STARR-seq mESC enhancer starr_27901 Neighboring gene STARR-seq mESC enhancer starr_27902 Neighboring gene potassium voltage gated channel, Shaw-related subfamily, member 2 Neighboring gene STARR-seq mESC enhancer starr_27903 Neighboring gene STARR-seq mESC enhancer starr_27905 Neighboring gene predicted gene, 40764

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Animal models of autism spectrum disorder (ASD): a synaptic-level approach to autistic-like behavior in mice. Shinoda Y, et al. Exp Anim, 2013. PMID 23615300
    2. CAPS2 deficiency affects environmental enrichment-induced adult neurogenesis and differentiation/survival of newborn neurons in the hippocampal dentate gyrus. Yagishita K, et al. Neurosci Lett, 2017 Nov 20. PMID 28963059
    3. Lack of stress responses to long-term effects of corticosterone in Caps2 knockout mice. Mishima Y, et al. Sci Rep, 2015 Mar 10. PMID 25754523, Free PMC Article
    4. Ca(2+)-dependent activator protein for secretion 2 and autistic-like phenotypes. Sadakata T, et al. Neurosci Res, 2010 Jul. PMID 20302894
    5. Cloning, characterization, and expression of calcyphosine 2, a novel human gene encoding an EF-hand Ca(2+)-binding protein. Wang S, et al. Biochem Biophys Res Commun, 2002 Feb 22. PMID 11846421

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CAPS2 Deficiency Impairs the Release of the Social Peptide Oxytocin, as Well as Oxytocin-Associated Social Behavior.
      Title: CAPS2 Deficiency Impairs the Release of the Social Peptide Oxytocin, as Well as Oxytocin-Associated Social Behavior.
    2. Epigenetic tuning of CAPS variants may allow modulation of endocrine adrenaline and noradrenaline release
      Title: An Alternative Exon of CAPS2 Influences Catecholamine Loading into LDCVs of Chromaffin Cells.
    3. that CAPS2 deficiency strongly impairs hippocampal adult neurogenesis and maturation of newborn neurons
      Title: CAPS2 deficiency affects environmental enrichment-induced adult neurogenesis and differentiation/survival of newborn neurons in the hippocampal dentate gyrus.
    4. These results suggest that Caps2 KO mice have altered endocrine responses to CORT administration, while maintaining CORT-induced anxiety/depressive-like behavior.
      Title: Lack of stress responses to long-term effects of corticosterone in Caps2 knockout mice.
    5. Naturally occurring splice variants of CAPS2 in CAPS1/CAPS2-deficient cells were studied and found that CAPS2 primes vesicles independently of its MUN domain.
      Title: Secretory vesicle priming by CAPS is independent of its SNARE-binding MUN domain.
    6. possible association of the dense-core vesicle secretion-related gene,CAPS2 with autism specturum disorder. (review)
      Title: Animal models of autism spectrum disorder (ASD): a synaptic-level approach to autistic-like behavior in mice.
    7. CAPS family proteins exert dual roles in DCV trafficking, mediating trafficking at both the secretion site for exocytosis and at the Golgi complex for biogenesis
      Title: Calcium-dependent activator protein for secretion 2 interacts with the class II ARF small GTPases and regulates dense-core vesicle trafficking.
    8. CAPS2 promotes activity-dependent brain-derived neurotrophic factor secretion during the postnatal period that is critical for the development of hippocampal GABAergic networks.
      Title: Calcium-dependent activator protein for secretion 2 (CAPS2) promotes BDNF secretion and is critical for the development of GABAergic interneuron network.
    9. CAPS2 KO mice will be a useful animal model to study the aspects of the neuropathology and behavior characteristics of neurodevelopmental disorders
      Title: Ca(2+)-dependent activator protein for secretion 2 and autistic-like phenotypes.
    10. The CAPS2-deficient mice show reduced secretion of BDNF and NT-3. And the cerebella of these mice exhibit developmental deficits, such as delayed development.
      Title: Developmentally regulated Ca2+-dependent activator protein for secretion 2 (CAPS2) is involved in BDNF secretion and is associated with autism susceptibility.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    calcyphosin-2
    Names
    calcyphosine 2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310675.1 → NP_001297604.1  calcyphosin-2 isoform 2

      See identical proteins and their annotated locations for NP_001297604.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC166263, AK085286
      Consensus CDS
      CCDS78896.1
      UniProtKB/Swiss-Prot
      E9Q2J8, G3X9M5, Q8BUG5, Q8C1J6
      UniProtKB/TrEMBL
      Q0VG46
      Related
      ENSMUSP00000089815.2, ENSMUST00000092176.8

    2. NM_178278.4 → NP_840062.2  calcyphosin-2 isoform 1

      See identical proteins and their annotated locations for NP_840062.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK015008, AK085286
      Consensus CDS
      CCDS24172.2
      UniProtKB/TrEMBL
      Q0VG46
      Related
      ENSMUSP00000129887.2, ENSMUST00000170013.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      111999254..112052466
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513814.4 → XP_006513877.1  calcyphosin-2 isoform X3

      See identical proteins and their annotated locations for XP_006513877.1

      UniProtKB/TrEMBL
      Q0VG46
      Conserved Domains (1) summary
      pfam13499
      Location:426 → 488
      EF-hand_7; EF-hand domain pair

    2. XM_006513815.1 → XP_006513878.1  calcyphosin-2 isoform X3

      See identical proteins and their annotated locations for XP_006513878.1

      UniProtKB/TrEMBL
      Q0VG46
      Conserved Domains (1) summary
      pfam13499
      Location:426 → 488
      EF-hand_7; EF-hand domain pair

    3. XM_006513816.1 → XP_006513879.1  calcyphosin-2 isoform X3

      See identical proteins and their annotated locations for XP_006513879.1

      UniProtKB/TrEMBL
      Q0VG46
      Conserved Domains (1) summary
      pfam13499
      Location:426 → 488
      EF-hand_7; EF-hand domain pair

    4. XM_036155868.1 → XP_036011761.1  calcyphosin-2 isoform X1

      UniProtKB/TrEMBL
      Q0VG46

    5. XM_011243499.1 → XP_011241801.1  calcyphosin-2 isoform X1

      See identical proteins and their annotated locations for XP_011241801.1

      UniProtKB/TrEMBL
      Q0VG46

    6. XM_006513818.1 → XP_006513881.1  calcyphosin-2 isoform X5

      UniProtKB/TrEMBL
      Q0VG46

    7. XM_006513817.4 → XP_006513880.1  calcyphosin-2 isoform X4

      UniProtKB/TrEMBL
      Q0VG46

    8. XM_006513813.4 → XP_006513876.1  calcyphosin-2 isoform X2

      UniProtKB/TrEMBL
      Q0VG46

    9. XM_006513820.4 → XP_006513883.1  calcyphosin-2 isoform X6

      UniProtKB/TrEMBL
      Q0VG46
      Conserved Domains (1) summary
      pfam13499
      Location:446 → 508
      EF-hand_7; EF-hand domain pair

    10. XM_006513821.4 → XP_006513884.1  calcyphosin-2 isoform X7

    11. XM_006513822.5 → XP_006513885.1  calcyphosin-2 isoform X8

    RNA

    1. XR_380413.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BUG5.2 GenPept UniProtKB/Swiss-Prot:Q8BUG5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous