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    Ric8b RIC8 guanine nucleotide exchange factor B [ Mus musculus (house mouse) ]

    Gene ID: 237422, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Ric8bprovided by MGI
    Official Full Name
    RIC8 guanine nucleotide exchange factor Bprovided by MGI
    Primary source
    MGI:MGI:2682307
    See related
    Ensembl:ENSMUSG00000035620 AllianceGenome:MGI:2682307
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ric-8; Ric-8b
    Summary
    Predicted to enable G-protein alpha-subunit binding activity and guanyl-nucleotide exchange factor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in cytosol. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and immune system. Orthologous to human RIC8B (RIC8 guanine nucleotide exchange factor B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 7.7), CNS E18 (RPKM 7.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10 C1; 10 41.63 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (84753136..84854201)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (84917268..85018337)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene regulatory factor X, 4 (influences HLA class II expression) Neighboring gene STARR-positive B cell enhancer ABC_E6894 Neighboring gene predicted gene, 53596 Neighboring gene predicted gene, 40728 Neighboring gene STARR-seq mESC enhancer starr_27430 Neighboring gene STARR-seq mESC enhancer starr_27432 Neighboring gene STARR-positive B cell enhancer ABC_E2956 Neighboring gene predicted gene, 34633 Neighboring gene STARR-seq mESC enhancer starr_27436 Neighboring gene STARR-seq mESC enhancer starr_27437 Neighboring gene STARR-seq mESC enhancer starr_27438 Neighboring gene predicted gene, 51826 Neighboring gene four and a half LIM domains 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The role of resistance to inhibitors of cholinesterase 8b in the control of heart rate. Sebastian S, et al. Physiol Genomics, 2021 Apr 1. PMID 33719582
    2. Increased ubiquitination and the crosstalk of G protein signaling in cardiac myocytes: involvement of Ric-8B in Gs suppression by Gq signal. Jenie RI, et al. Genes Cells, 2013 Dec. PMID 24134321
    3. Ric-8B promotes functional expression of odorant receptors. Von Dannecker LE, et al. Proc Natl Acad Sci U S A, 2006 Jun 13. PMID 16754875, Free PMC Article
    4. Conditional Deletion of Ric-8b in Olfactory Sensory Neurons Leads to Olfactory Impairment. Machado CF, et al. J Neurosci, 2017 Dec 13. PMID 29118104, Free PMC Article
    5. A functional N-terminal domain in C/EBPβ-LAP* is required for interacting with SWI/SNF and to repress Ric-8B gene transcription in osteoblasts. Aguilar R, et al. J Cell Physiol, 2014 Oct. PMID 24585571, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The role of resistance to inhibitors of cholinesterase 8b in the control of heart rate.
      Title: The role of resistance to inhibitors of cholinesterase 8b in the control of heart rate.
    2. A crucial role for Ric-8B in development and novel insights into the signals that regulate mTORC2.
      Title: Depletion of Ric-8B leads to reduced mTORC2 activity.
    3. Olfactory-specific Ric-8b knock-out mice of mixed sex do not express the Galphaolf protein in the olfactory epithelium. The mature olfactory sensory neuron layer is reduced and cell death increased. These mice have an impaired sense of smell. Ric-8b is essential for olfactory function, and it may also be essential for Galphaolf-dependent functions in the brain.
      Title: Conditional Deletion of Ric-8b in Olfactory Sensory Neurons Leads to Olfactory Impairment.
    4. Data show that the localization of maternally expressed RIC8 protein is highly dynamic and is dependent on the stage of folliculogenesis, oogenesis and cleavage, and imply that it may have a regulatory function in mammalian gametogenesis.
      Title: Expression Pattern and Localization Dynamics of Guanine Nucleotide Exchange Factor RIC8 during Mouse Oogenesis.
    5. Results indicate that a functional N-terminus in C/EBPbeta-LAP* is required for interacting with SWI/SNF and for Ric-8B gene repression in osteoblasts.
      Title: A functional N-terminal domain in C/EBPβ-LAP* is required for interacting with SWI/SNF and to repress Ric-8B gene transcription in osteoblasts.
    6. a new role of Ric-8B in the crosstalk of two distinct G protein signaling pathways, which are possibly involved in a part of mechanisms of chronic heart failure.
      Title: Increased ubiquitination and the crosstalk of G protein signaling in cardiac myocytes: involvement of Ric-8B in Gs suppression by Gq signal.
    7. data suggest that Ric-8 proteins are molecular chaperones required for the initial association of nascent Galpha subunits with cellular membranes
      Title: Ric-8 proteins are molecular chaperones that direct nascent G protein α subunit membrane association.
    8. Data show that the Ric-8B gene is negatively regulated during osteoblast differentiation by the transcription factor C/EBPbeta.
      Title: The Ric-8B gene is highly expressed in proliferating preosteoblastic cells and downregulated during osteoblast differentiation in a SWI/SNF- and C/EBPbeta-mediated manner.
    9. Ric-8BFL-catalyzed nucleotide exchange probably proceeds in the forward direction to produce Galpha-GTP in cells.
      Title: Ric-8B is a GTP-dependent G protein alphas guanine nucleotide exchange factor.
    10. Ric-8B plays a critical and specific role in the control of G alpha(s) protein levels by modulating G alpha(s) ubiquitination and positively regulates G(s) signaling
      Title: Ric-8B stabilizes the alpha subunit of stimulatory G protein by inhibiting its ubiquitination.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (3) 
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC58970

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G-protein alpha-subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    synembryn-B
    Names
    resistance to inhibitors of cholinesterase 8 homolog B
    resistance to inhibitors of cholinesterase 8B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013441.2 → NP_001013459.1  synembryn-B isoform 1

      See identical proteins and their annotated locations for NP_001013459.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AY940667, BC040762, BY272676
      Consensus CDS
      CCDS24084.1
      UniProtKB/Swiss-Prot
      Q58L65, Q80XE1
      Related
      ENSMUSP00000093032.4, ENSMUST00000095385.5
      Conserved Domains (1) summary
      pfam10165
      Location:66 → 483
      Ric8; Guanine nucleotide exchange factor synembryn

    2. NM_183172.2 → NP_898995.1  synembryn-B isoform 2

      See identical proteins and their annotated locations for NP_898995.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate in-frame exon in the coding region compared to variant 1. It encodes isoform 2, which is longer than isoform 1.
      Source sequence(s)
      BC040762, BC051080, BY272676
      Consensus CDS
      CCDS24085.1
      UniProtKB/Swiss-Prot
      Q80XE1
      Related
      ENSMUSP00000046981.8, ENSMUST00000038523.15
      Conserved Domains (1) summary
      pfam10165
      Location:66 → 537
      Ric8; Guanine nucleotide exchange factor synembryn

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      84753136..84854201
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155776.1 → XP_036011669.1  synembryn-B isoform X2

      Conserved Domains (1) summary
      pfam10165
      Location:66 → 493
      Ric8; Guanine nucleotide exchange factor synembryn

    2. XM_036155777.1 → XP_036011670.1  synembryn-B isoform X3

      Conserved Domains (1) summary
      pfam10165
      Location:66 → 451
      Ric8; Guanine nucleotide exchange factor synembryn

    3. XM_006513625.4 → XP_006513688.1  synembryn-B isoform X1

      Conserved Domains (1) summary
      pfam10165
      Location:66 → 524
      Ric8; Guanine nucleotide exchange factor synembryn

    RNA

    1. XR_380392.4 RNA Sequence

    2. XR_380394.5 RNA Sequence

    3. XR_004936177.1 RNA Sequence

    4. XR_380393.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80XE1.2 GenPept UniProtKB/Swiss-Prot:Q80XE1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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