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    Tab3 TGF-beta activated kinase 1/MAP3K7 binding protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 66724, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Tab3provided by MGI
    Official Full Name
    TGF-beta activated kinase 1/MAP3K7 binding protein 3provided by MGI
    Primary source
    MGI:MGI:1913974
    See related
    Ensembl:ENSMUSG00000035476 AllianceGenome:MGI:1913974
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Map3k7ip3; mKIAA4135; 4921526G09Rik
    Summary
    Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity and zinc ion binding activity. Predicted to be involved in positive regulation of I-kappaB kinase/NF-kappaB signaling. Is expressed in several structures, including adrenal gland; gonad; liver; lung; and spleen. Orthologous to human TAB3 (TGF-beta activated kinase 1 (MAP3K7) binding protein 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver E14 (RPKM 4.3), placenta adult (RPKM 4.2) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    X C1; X 39.32 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (84617466..84678075)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (85573854..85634469)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene 16463 Neighboring gene ferritin, heavy polypeptide-like 17, member A Neighboring gene STARR-seq mESC enhancer starr_47493 Neighboring gene STARR-seq mESC enhancer starr_47494 Neighboring gene predicted gene, 39523 Neighboring gene STARR-seq mESC enhancer starr_47495 Neighboring gene STARR-seq mESC enhancer starr_47496 Neighboring gene STARR-positive B cell enhancer ABC_E8762 Neighboring gene glycerol kinase Neighboring gene replication protein A 14 kDa subunit pseudogene Neighboring gene TLR adaptor interacting with endolysosomal SLC15A4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TAB3 defect induces augmented cardioprotection loss from ischemic injury. Sheng Y, et al. Cell Biol Int, 2017 Jul. PMID 28462515
    2. Smads keep TABs on inflammation. Seth RB, et al. Nat Immunol, 2007 May. PMID 17440456
    3. Essential roles of K63-linked polyubiquitin-binding proteins TAB2 and TAB3 in B cell activation via MAPKs. Ori D, et al. J Immunol, 2013 Apr 15. PMID 23509369
    4. TAB3, a new binding partner of the protein kinase TAK1. Cheung PC, et al. Biochem J, 2004 Feb 15. PMID 14670075, Free PMC Article
    5. Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by NZF domains of TAB2 and TAB3. Sato Y, et al. EMBO J, 2009 Dec 16. PMID 19927120, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Findings indicate that the absence of TAB3 plays a harmful role in ischemic heart disease
      Title: TAB3 defect induces augmented cardioprotection loss from ischemic injury.
    2. TAB2 and TAB3 are essential for B cell activation leading to antigen-specific antibody responses, as well as B-1 and marginal zone B cell development.
      Title: Essential roles of K63-linked polyubiquitin-binding proteins TAB2 and TAB3 in B cell activation via MAPKs.
    3. MiR-23b suppresses IL-17-, tumor necrosis factor alpha (TNF-alpha)- or IL-1beta-induced NF-kappaB activation and inflammatory cytokine expression by targeting TAB2, TAB3 and IKK-alpha.
      Title: The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • KIAA4135

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables K63-linked polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
    Names
    TAK1-binding protein 3
    TGF-beta-activated kinase 1-binding protein 3
    mitogen-activated protein kinase kinase kinase 7-interacting protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358447.1 → NP_001345376.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

      Status: VALIDATED

      Source sequence(s)
      AL645567, AL645586, BC090666
      Consensus CDS
      CCDS41049.1
      UniProtKB/Swiss-Prot
      Q571K4
      UniProtKB/TrEMBL
      B1ASY9
      Conserved Domains (3) summary
      smart00547
      Location:691 → 713
      ZnF_RBZ; Zinc finger domain
      cd14362
      Location:9 → 50
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      sd00029
      Location:691 → 710
      zf-RanBP2; RanBP2-type Zn finger [structural motif]

    2. NM_025729.4 → NP_080005.2  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

      See identical proteins and their annotated locations for NP_080005.2

      Status: VALIDATED

      Source sequence(s)
      AK048222, AK220185, BC090666
      Consensus CDS
      CCDS41049.1
      UniProtKB/Swiss-Prot
      Q571K4
      UniProtKB/TrEMBL
      B1ASY9
      Related
      ENSMUSP00000039668.4, ENSMUST00000048250.10
      Conserved Domains (3) summary
      smart00547
      Location:691 → 713
      ZnF_RBZ; Zinc finger domain
      cd14362
      Location:9 → 50
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      sd00029
      Location:691 → 710
      zf-RanBP2; RanBP2-type Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      84617466..84678075
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251478.2 → XP_030107338.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1

      UniProtKB/Swiss-Prot
      Q571K4
      UniProtKB/TrEMBL
      B1ASY9
      Conserved Domains (3) summary
      smart00547
      Location:691 → 713
      ZnF_RBZ; Zinc finger domain
      cd14362
      Location:9 → 50
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      sd00029
      Location:691 → 710
      zf-RanBP2; RanBP2-type Zn finger [structural motif]

    2. XM_030251476.2 → XP_030107336.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1

      UniProtKB/Swiss-Prot
      Q571K4
      UniProtKB/TrEMBL
      B1ASY9
      Conserved Domains (3) summary
      smart00547
      Location:691 → 713
      ZnF_RBZ; Zinc finger domain
      cd14362
      Location:9 → 50
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      sd00029
      Location:691 → 710
      zf-RanBP2; RanBP2-type Zn finger [structural motif]

    3. XM_030251479.2 → XP_030107339.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1

      UniProtKB/Swiss-Prot
      Q571K4
      UniProtKB/TrEMBL
      B1ASY9
      Conserved Domains (3) summary
      smart00547
      Location:691 → 713
      ZnF_RBZ; Zinc finger domain
      cd14362
      Location:9 → 50
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      sd00029
      Location:691 → 710
      zf-RanBP2; RanBP2-type Zn finger [structural motif]

    4. XM_006528238.5 → XP_006528301.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006528301.1

      UniProtKB/Swiss-Prot
      Q571K4
      UniProtKB/TrEMBL
      B1ASY9
      Conserved Domains (3) summary
      smart00547
      Location:691 → 713
      ZnF_RBZ; Zinc finger domain
      cd14362
      Location:9 → 50
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      sd00029
      Location:691 → 710
      zf-RanBP2; RanBP2-type Zn finger [structural motif]

    5. XM_030251477.2 → XP_030107337.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1

      UniProtKB/Swiss-Prot
      Q571K4
      UniProtKB/TrEMBL
      B1ASY9
      Conserved Domains (3) summary
      smart00547
      Location:691 → 713
      ZnF_RBZ; Zinc finger domain
      cd14362
      Location:9 → 50
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      sd00029
      Location:691 → 710
      zf-RanBP2; RanBP2-type Zn finger [structural motif]

    6. XM_006528239.4 → XP_006528302.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006528302.1

      UniProtKB/Swiss-Prot
      Q571K4
      UniProtKB/TrEMBL
      B1ASY9
      Conserved Domains (3) summary
      smart00547
      Location:691 → 713
      ZnF_RBZ; Zinc finger domain
      cd14362
      Location:9 → 50
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      sd00029
      Location:691 → 710
      zf-RanBP2; RanBP2-type Zn finger [structural motif]

    RNA

    1. XR_003953021.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q571K4.2 GenPept UniProtKB/Swiss-Prot:Q571K4

    Gene LinkOut

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