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    Thyn1 thymocyte nuclear protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 77862, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Thyn1provided by MGI
    Official Full Name
    thymocyte nuclear protein 1provided by MGI
    Primary source
    MGI:MGI:1925112
    See related
    Ensembl:ENSMUSG00000035443 AllianceGenome:MGI:1925112
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MY105; Thy28; MDS012; HSPC144; D730042P09Rik
    Summary
    Located in nucleus. Orthologous to human THYN1 (thymocyte nuclear protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 15.5), CNS E11.5 (RPKM 15.3) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 A4; 9 12.06 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (26910950..26918632)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (26999642..27007336)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene zinc finger CCCH type containing 11A pseudogene Neighboring gene acyl-Coenzyme A dehydrogenase family, member 8 Neighboring gene STARR-positive B cell enhancer ABC_E8282 Neighboring gene VPS26 retromer complex component B Neighboring gene STARR-positive B cell enhancer ABC_E8283 Neighboring gene STARR-positive B cell enhancer ABC_E3819 Neighboring gene non-SMC condensin II complex, subunit D3 Neighboring gene STARR-seq mESC enhancer starr_23617 Neighboring gene junction adhesion molecule 3 Neighboring gene STARR-seq mESC enhancer starr_23618 Neighboring gene predicted gene, 57534

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Normal B cell development and Pax5 expression in Thy28/ThyN1-deficient mice. Kitaura F, et al. PLoS One, 2019. PMID 31329649, Free PMC Article
    2. Thy28 protects against anti-CD3-mediated thymic cell death in vivo. Toyota H, et al. Apoptosis, 2015 Apr. PMID 25547913
    3. Thy28 partially prevents apoptosis induction following engagement of membrane immunoglobulin in WEHI-231 B lymphoma cells. Toyota H, et al. Cell Mol Biol Lett, 2012 Mar. PMID 22139584, Free PMC Article
    4. Modulation of mThy28 nuclear protein expression during thymocyte development. Jiang X, et al. Tissue Cell, 2003 Dec. PMID 14580360
    5. Anti-IgM-induced down-regulation of nuclear Thy28 protein expression in Ramos B lymphoma cells. Jiang XZ, et al. Apoptosis, 2003 Oct. PMID 14601557

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Thy28-deficient mice showed normal development of B cells and unaltered Pax5 expression.
      Title: Normal B cell development and Pax5 expression in Thy28/ThyN1-deficient mice.
    2. Modulation of Thy28 expression plays a crucial role in the determination of thymic cell fate.
      Title: Thy28 protects against anti-CD3-mediated thymic cell death in vivo.
    3. Thy28 regulates mIg-mediated apoptotic events through the JNK-H(2)O(2) activation pathway, concomitant with an accumulation of cells in G1 phase associated with upregulation of p27(Kip1)
      Title: Thy28 partially prevents apoptosis induction following engagement of membrane immunoglobulin in WEHI-231 B lymphoma cells.
    4. down-regulation of the nuclear Thy28 expression appears to correlate with the induction of apoptosis in Ramos B lymphoma cells
      Title: Anti-IgM-induced down-regulation of nuclear Thy28 protein expression in Ramos B lymphoma cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    thymocyte nuclear protein 1
    Names
    mThy28
    thymocyte protein thy28

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001326361.1 → NP_001313290.1  thymocyte nuclear protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks a frame-shifting internal exon, compared to variant 1. This variant encodes a shorter protein (isoform 2) with a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK077639, BE953030, BY253816, DV062524
      Consensus CDS
      CCDS90522.1
      UniProtKB/TrEMBL
      Q8BJZ7
      Related
      ENSMUSP00000151200.2, ENSMUST00000213770.2
      Conserved Domains (1) summary
      cl00728
      Location:56 → 161
      EVE; EVE domain

    2. NM_144543.2 → NP_653126.1  thymocyte nuclear protein 1 isoform 1

      See identical proteins and their annotated locations for NP_653126.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AB080370, BE953030, CB236103
      Consensus CDS
      CCDS22937.1
      UniProtKB/Swiss-Prot
      Q91YJ3
      Related
      ENSMUSP00000037614.9, ENSMUST00000039161.10
      Conserved Domains (1) summary
      cl00728
      Location:56 → 225
      EVE; EVE domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      26910950..26918632
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510691.4 → XP_006510754.1  thymocyte nuclear protein 1 isoform X3

    2. XM_006510692.5 → XP_006510755.1  thymocyte nuclear protein 1 isoform X4

    3. XM_006510688.5 → XP_006510751.1  thymocyte nuclear protein 1 isoform X1

      Conserved Domains (1) summary
      cl00728
      Location:79 → 248
      EVE; EVE domain

    4. XM_006510689.5 → XP_006510752.1  thymocyte nuclear protein 1 isoform X2

      Conserved Domains (1) summary
      cl00728
      Location:79 → 184
      EVE; EVE domain

    RNA

    1. XR_004935604.1 RNA Sequence

    2. XR_001779072.3 RNA Sequence

    3. XR_003948057.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91YJ3.1 GenPept UniProtKB/Swiss-Prot:Q91YJ3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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