Shc4 SHC (Src homology 2 domain containing) family, member 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Shc4provided by MGI
Official Full Name: SHC (Src homology 2 domain containing) family, member 4provided by MGI
Primary source: MGI:MGI:2655364
See related: Ensembl:ENSMUSG00000035109 AllianceGenome:MGI:2655364
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RaLP; Gm685; 6230417E10Rik; 9930029B02Rik
Summary: Enables protein domain specific binding activity and receptor tyrosine kinase binding activity. Acts upstream of or within several processes, including apoptotic process; positive regulation of cell population proliferation; and stem cell differentiation. Predicted to be located in postsynaptic membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; heart; sensory organ; and skin. Orthologous to human SHC4 (SHC adaptor protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in genital fat pad adult (RPKM 3.4), testis adult (RPKM 2.5) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 F1; 2 61.76 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (125469359..125566085, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (125627439..125724148, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

data also showed that the death signalling initiated by the ShcD/ERK interaction was accompanied by p21 phosphorylation. In summary, these data identified ShcD, via its interaction with ERK, as a proapoptotic protein under oxidative stress conditions.
Title: Studying the ShcD and ERK interaction under acute oxidative stress conditions in melanoma cells.
Shc4 is an important modulator in the switch of key pathway(s) involved in determining epiblast stem cell identity.
Title: Cellular heterogeneity during embryonic stem cell differentiation to epiblast stem cells is revealed by the ShcD/RaLP adaptor protein.
The unique tissue distribution patterns of Shc proteins likely contribute to their complex tissue-specific signaling functions during embryogenesis.
Title: Expression patterns of ShcD and Shc family adaptor proteins during mouse embryonic development.
A new member of the Shc family of docking proteins is characterised, which may mediate a specific aspect of signaling downstream of the MuSK receptor.
Title: Analysis of a Shc family adaptor protein, ShcD/Shc4, that associates with muscle-specific kinase.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D2Mit398 (e-PCR), detects polymorphism
- UniSTS:129299

NoName (e-PCR)
- UniSTS:234517

Shc4 (e-PCR), detects polymorphism
- UniSTS:532502

D2Mit105 (e-PCR), detects polymorphism
- UniSTS:128964

D2Dcr70 (e-PCR), detects polymorphism
- UniSTS:507629

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor tyrosine kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables receptor tyrosine kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: SHC-transforming protein 4

Names: SH2 domain protein C4; SHC-transforming protein D; mShcD; novel phosphotyrosine interaction domain (PTB/PID) and SH2 domains containing protein; rai-like protein RaLP; src homology 2 domain-containing-transforming protein C4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199022.3 → NP_950187.1 SHC-transforming protein 4

See identical proteins and their annotated locations for NP_950187.1

Status: VALIDATED

Source sequence(s)

AL844580, AL929166

Consensus CDS

CCDS16678.1

UniProtKB/Swiss-Prot

Q6S5L9

Related

ENSMUSP00000043146.8, ENSMUST00000042246.14

Conserved Domains (2) summary

cd09925
Location:513 → 614

SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)

cd01209
Location:181 → 347

PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

125469359..125566085 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036162265.1 → XP_036018158.1 SHC-transforming protein 4 isoform X2

UniProtKB/TrEMBL

A2AUN0

Related

ENSMUSP00000106106.2, ENSMUST00000110480.8

Conserved Domains (2) summary

cd09925
Location:227 → 328

SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)

cl17171
Location:1 → 61

PH-like; Pleckstrin homology-like domain
XM_006499655.5 → XP_006499718.3 SHC-transforming protein 4 isoform X1

Conserved Domains (2) summary

cd09925
Location:297 → 398

SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)

cl17171
Location:63 → 131

PH-like; Pleckstrin homology-like domain