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    Dpp4 dipeptidylpeptidase 4 [ Mus musculus (house mouse) ]

    Gene ID: 13482, updated on 16-Apr-2024

    Summary

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    Official Symbol
    Dpp4provided by MGI
    Official Full Name
    dipeptidylpeptidase 4provided by MGI
    Primary source
    MGI:MGI:94919
    See related
    Ensembl:ENSMUSG00000035000 AllianceGenome:MGI:94919
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cd26; THAM; Dpp-4
    Summary
    Predicted to enable several functions, including chemorepellent activity; peptidase activity; and protein homodimerization activity. Acts upstream of or within behavioral fear response; locomotory exploration behavior; and psychomotor behavior. Located in intercellular canaliculus. Is expressed in several structures, including genitourinary system; inner ear; intraembryonic coelom; liver; and primitive heart tube. Used to study Middle East respiratory syndrome. Human ortholog(s) of this gene implicated in Middle East respiratory syndrome and type 2 diabetes mellitus. Orthologous to human DPP4 (dipeptidyl peptidase 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in large intestine adult (RPKM 30.2), small intestine adult (RPKM 11.7) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dpp4 in Genome Data Viewer
    Location:
    2 C1.3; 2 35.85 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (62160417..62242635, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (62330073..62412315, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_04636 Neighboring gene U1 small nuclear ribonucleoprotein C pseudogene Neighboring gene solute carrier family 4, sodium bicarbonate cotransporter-like, member 10 Neighboring gene STARR-seq mESC enhancer starr_04637 Neighboring gene STARR-positive B cell enhancer mm9_chr2:62123780-62124080 Neighboring gene STARR-positive B cell enhancer mm9_chr2:62229877-62230177 Neighboring gene STARR-seq mESC enhancer starr_04638 Neighboring gene STARR-seq mESC enhancer starr_04639 Neighboring gene STARR-positive B cell enhancer ABC_E5925 Neighboring gene STARR-positive B cell enhancer ABC_E8786 Neighboring gene STARR-positive B cell enhancer ABC_E8787 Neighboring gene STARR-seq mESC enhancer starr_04641 Neighboring gene STARR-positive B cell enhancer ABC_E3379 Neighboring gene STARR-positive B cell enhancer ABC_E2037 Neighboring gene STARR-positive B cell enhancer ABC_E5926 Neighboring gene STARR-positive B cell enhancer ABC_E5927 Neighboring gene Gcg promoter region Neighboring gene predicted gene 13561 Neighboring gene glucagon

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Functional roles of CD26/DPP4 in bleomycin-induced pulmonary fibrosis. Koyanagi Y, et al. Physiol Rep, 2023 Mar. PMID 36949656, Free PMC Article
    2. Hepatocyte-derived DPP4 regulates portal GLP-1 bioactivity, modulates glucose production, and when absent influences NAFLD progression. Trzaskalski NA, et al. JCI Insight, 2023 Jan 24. PMID 36472923, Free PMC Article
    3. SARS-CoV-2 infection of sustentacular cells disrupts olfactory signaling pathways. Verma AK, et al. JCI Insight, 2022 Dec 22. PMID 36378534, Free PMC Article
    4. CD26 Deficiency Controls Macrophage Polarization Markers and Signal Transducers during Colitis Development and Resolution. Vukelic I, et al. Int J Mol Sci, 2022 May 14. PMID 35628317, Free PMC Article
    5. Prediabetes blunts DPP4 genetic control of postprandial glycaemia and insulin secretion. Patarrão RS, et al. Diabetologia, 2022 May. PMID 35190847, Free PMC Article

    See all (220) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dipeptidyl Peptidase 4 Stimulation Induces Adipogenesis-Related Gene Expression of Adipose Stromal Cells.
      Title: Dipeptidyl Peptidase 4 Stimulation Induces Adipogenesis-Related Gene Expression of Adipose Stromal Cells.
    2. Dipeptidylpeptidase 4 promotes survival and stemness of acute myeloid leukemia stem cells.
      Title: Dipeptidylpeptidase 4 promotes survival and stemness of acute myeloid leukemia stem cells.
    3. Functional roles of CD26/DPP4 in bleomycin-induced pulmonary fibrosis.
      Title: Functional roles of CD26/DPP4 in bleomycin-induced pulmonary fibrosis.
    4. Dipeptidyl Peptidase 4/Midline-1 Axis Promotes T Lymphocyte Motility in Atherosclerosis.
      Title: Dipeptidyl Peptidase 4/Midline-1 Axis Promotes T Lymphocyte Motility in Atherosclerosis.
    5. FFA-Fetuin-A regulates DPP-IV expression in pancreatic beta cells through TLR4-NFkB pathway.
      Title: FFA-Fetuin-A regulates DPP-IV expression in pancreatic beta cells through TLR4-NFkB pathway.
    6. Hepatocyte-derived DPP4 regulates portal GLP-1 bioactivity, modulates glucose production, and when absent influences NAFLD progression.
      Title: Hepatocyte-derived DPP4 regulates portal GLP-1 bioactivity, modulates glucose production, and when absent influences NAFLD progression.
    7. Nonenzymatic function of DPP4 promotes diabetes-associated cognitive dysfunction through IGF-2R/PKA/SP1/ERp29/IP3R2 pathway-mediated impairment of Treg function and M1 microglia polarization.
      Title: Nonenzymatic function of DPP4 promotes diabetes-associated cognitive dysfunction through IGF-2R/PKA/SP1/ERp29/IP3R2 pathway-mediated impairment of Treg function and M1 microglia polarization.
    8. Dipeptidyl peptidase IV inhibition delays developmental programming of obesity and metabolic disease in male offspring of obese mothers.
      Title: Dipeptidyl peptidase IV inhibition delays developmental programming of obesity and metabolic disease in male offspring of obese mothers.
    9. CD26 Deficiency Controls Macrophage Polarization Markers and Signal Transducers during Colitis Development and Resolution.
      Title: CD26 Deficiency Controls Macrophage Polarization Markers and Signal Transducers during Colitis Development and Resolution.
    10. Skin Fibrosis and Recovery Is Dependent on Wnt Activation via DPP4.
      Title: Skin Fibrosis and Recovery Is Dependent on Wnt Activation via DPP4.
    Submit: New GeneRIF Correction See all GeneRIFs (117)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chemorepellent activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables collagen binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dipeptidyl-peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dipeptidyl-peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine-type peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables virus receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in B-1a B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in T cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in T cell costimulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within behavioral fear response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within locomotory exploration behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of extracellular matrix disassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of neutrophil chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of natural killer cell mediated immunity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within psychomotor behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of T cell mediated immunity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell-cell adhesion mediated by integrin ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intercellular canaliculus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dipeptidyl peptidase 4
    Names
    DPP IV
    T-cell activation antigen CD26
    dipeptidyl peptidase IV
    thymocyte-activating molecule
    NP_001153015.1
    NP_034204.1
    XP_006498754.1
    XP_006498755.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159543.1 → NP_001153015.1  dipeptidyl peptidase 4 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK085370, AK163085, AL928804
      UniProtKB/TrEMBL
      Q3TR43
      Conserved Domains (3) summary
      pfam00930
      Location:102 → 472
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
      pfam00326
      Location:553 → 729
      Peptidase_S9; Prolyl oligopeptidase family
      pfam18811
      Location:36 → 56
      DPPIV_rep; Dipeptidyl peptidase IV (DPP IV) low complexity region

    2. NM_010074.3 → NP_034204.1  dipeptidyl peptidase 4 isoform 1

      See identical proteins and their annotated locations for NP_034204.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK085370, AK163085, AL928804
      Consensus CDS
      CCDS16065.1
      UniProtKB/Swiss-Prot
      P28843, Q3U514
      UniProtKB/TrEMBL
      Q3TR43
      Related
      ENSMUSP00000044050.8, ENSMUST00000047812.8
      Conserved Domains (3) summary
      COG1506
      Location:392 → 758
      DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
      pfam00326
      Location:553 → 757
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:102 → 472
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      62160417..62242635 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498691.5 → XP_006498754.1  dipeptidyl peptidase 4 isoform X2

      UniProtKB/TrEMBL
      Q3TR43
      Conserved Domains (3) summary
      pfam00930
      Location:102 → 472
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
      pfam18811
      Location:37 → 56
      DPPIV_rep; Dipeptidyl peptidase IV (DPP IV) low complexity region
      cl21494
      Location:553 → 678
      Abhydrolase; alpha/beta hydrolases

    2. XM_006498692.5 → XP_006498755.1  dipeptidyl peptidase 4 isoform X1

      UniProtKB/TrEMBL
      Q3TR43
      Conserved Domains (3) summary
      pfam00930
      Location:102 → 472
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
      pfam18811
      Location:37 → 56
      DPPIV_rep; Dipeptidyl peptidase IV (DPP IV) low complexity region
      cl21494
      Location:553 → 679
      Abhydrolase; alpha/beta hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P28843.3 GenPept UniProtKB/Swiss-Prot:P28843

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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