Tmem127 transmembrane protein 127 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmem127provided by MGI
Official Full Name: transmembrane protein 127provided by MGI
Primary source: MGI:MGI:1916720
See related: Ensembl:ENSMUSG00000034850 AllianceGenome:MGI:1916720
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2310003P10Rik
Summary: Predicted to enable small GTPase binding activity. Acts upstream of or within endosome organization and regulation of TOR signaling. Predicted to be located in early endosome and plasma membrane. Predicted to be active in membrane. Is expressed in medulla oblongata basal plate and ventral grey horn. Human ortholog(s) of this gene implicated in pheochromocytoma. Orthologous to human TMEM127 (transmembrane protein 127). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in colon adult (RPKM 24.1), ovary adult (RPKM 23.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 F1; 2 61.87 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (127089868..127103028)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (127247904..127261108)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hepatic transmembrane protein 127 (Tmem127) expression is increased in insulin-resistant states.
Title: The tumor suppressor TMEM127 regulates insulin sensitivity in a tissue-specific manner.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

AI314202 (e-PCR)
- UniSTS:178703

AI317350 (e-PCR)
- UniSTS:159020

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within endosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of TOR signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of TOR signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of TOR signaling	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transmembrane protein 127

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.