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    Rhov ras homolog family member V [ Mus musculus (house mouse) ]

    Gene ID: 228543, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Rhovprovided by MGI
    Official Full Name
    ras homolog family member Vprovided by MGI
    Primary source
    MGI:MGI:2444227
    See related
    Ensembl:ENSMUSG00000034226 AllianceGenome:MGI:2444227
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Arhv; A030005A06Rik
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in several processes, including Cdc42 protein signal transduction; cell projection assembly; and endocytosis. Predicted to be located in endosome and plasma membrane. Is expressed in alimentary system; central nervous system; lower urinary tract; nose; and skin. Orthologous to human RHOV (ras homolog family member V). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in bladder adult (RPKM 11.6), testis adult (RPKM 5.9) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 E5; 2 59.97 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (119099682..119108489, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (119269201..119278008, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory inhibitor subunit 14D Neighboring gene serine protease inhibitor, Kunitz type 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:119076669-119076852 Neighboring gene STARR-seq mESC enhancer starr_05478 Neighboring gene STARR-positive B cell enhancer ABC_E3394 Neighboring gene ribosomal protein S27 pseudogene Neighboring gene VPS18 CORVET/HOPS core subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RNA profiling and chromatin immunoprecipitation-sequencing reveal that PTF1a stabilizes pancreas progenitor identity via the control of MNX1/HLXB9 and a network of other transcription factors. Thompson N, et al. Mol Cell Biol, 2012 Mar. PMID 22232429, Free PMC Article
    2. Profiling, Bioinformatic, and Functional Data on the Developing Olfactory/GnRH System Reveal Cellular and Molecular Pathways Essential for This Process and Potentially Relevant for the Kallmann Syndrome. Garaffo G, et al. Front Endocrinol (Lausanne), 2013. PMID 24427155, Free PMC Article
    3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC29297

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Cdc42 protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment or maintenance of cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    rho-related GTP-binding protein RhoV
    Names
    ras homolog gene family, member V

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145530.2 → NP_663505.1  rho-related GTP-binding protein RhoV

      See identical proteins and their annotated locations for NP_663505.1

      Status: VALIDATED

      Source sequence(s)
      AK037170, AL929318
      Consensus CDS
      CCDS16598.1
      UniProtKB/Swiss-Prot
      Q8VDU1
      Related
      ENSMUSP00000041411.8, ENSMUST00000037360.8
      Conserved Domains (1) summary
      cd04130
      Location:32 → 205
      Wrch_1; Wnt-1 responsive Cdc42 homolog (Wrch-1) is a Rho family GTPase similar to Cdc42

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      119099682..119108489 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011239465.1 → XP_011237767.1  rho-related GTP-binding protein RhoV isoform X1

      Conserved Domains (1) summary
      cd04130
      Location:77 → 250
      Wrch_1; Wnt-1 responsive Cdc42 homolog (Wrch-1) is a Rho family GTPase similar to Cdc42
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VDU1.1 GenPept UniProtKB/Swiss-Prot:Q8VDU1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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