Srsf2 serine and arginine-rich splicing factor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Srsf2provided by MGI
Official Full Name: serine and arginine-rich splicing factor 2provided by MGI
Primary source: MGI:MGI:98284
See related: Ensembl:ENSMUSG00000034120 AllianceGenome:MGI:98284
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SC35; MRF-1; Pr264; Sfrs2; Sfrs10; D11Wsu175e
Summary: The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. [provided by RefSeq, Sep 2010]
Expression: Ubiquitous expression in ovary adult (RPKM 340.2), thymus adult (RPKM 275.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 81.49 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (116740723..116744511, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (116849897..116853675, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SRSF2 mutation reduces polycythemia and impairs hematopoietic progenitor functions in JAK2V617F-driven myeloproliferative neoplasm.
Title: SRSF2 mutation reduces polycythemia and impairs hematopoietic progenitor functions in JAK2V617F-driven myeloproliferative neoplasm.
SRSF2-P95H decreases JAK/STAT signaling in hematopoietic cells and delays myelofibrosis development in mice.
Title: SRSF2-P95H decreases JAK/STAT signaling in hematopoietic cells and delays myelofibrosis development in mice.
SRSF2 in Sertoli cells is essential for testicular development and spermatogenesis in mice.
Title: SRSF2 in Sertoli cells is essential for testicular development and spermatogenesis in mice.
RUNX1 deficiency cooperates with SRSF2 mutation to induce multilineage hematopoietic defects characteristic of MDS.
Title: RUNX1 deficiency cooperates with SRSF2 mutation to induce multilineage hematopoietic defects characteristic of MDS.
Srsf2[P95H/+] co-operates with loss of TET2 to promote myeloid bias and initiate a chronic myelomonocytic leukemia-like disease in mice.
Title: Srsf2(P95H/+) co-operates with loss of TET2 to promote myeloid bias and initiate a chronic myelomonocytic leukemia-like disease in mice.
Genome-wide screening identifies cell-cycle control as a synthetic lethal pathway with SRSF2P95H mutation.
Title: Genome-wide screening identifies cell-cycle control as a synthetic lethal pathway with SRSF2P95H mutation.
Loss of SRSF2 triggers hepatic progenitor cell activation and tumor development in mice.
Title: Loss of SRSF2 triggers hepatic progenitor cell activation and tumor development in mice.
In a new conditional murine Srsf2(P95H) model, where the P95H mutation is expressed physiologically and heterozygously from its endogenous locus after Cre activation, the mutation must occur in the hemopoietic stem-cell-containing populations to promote myelomonocytic bias and expansion with transcriptional and RNA splicing changes. With age, nontransplanted mutant animals develop progressive, transplantablable disease.
Title: Srsf2(P95H) initiates myeloid bias and myelodysplastic/myeloproliferative syndrome from hemopoietic stem cells.
Mutant Srsf2 leads to a compromised Hematopoietic stem cell function by causing abnormal RNA splicing and expression, contributing to the deregulated hematopoiesis that recapitulates the Myelodysplastic syndromes phenotypes, possibly as a result of additional genetic and/or environmental insults.
Title: Physiological Srsf2 P95H expression causes impaired hematopoietic stem cell functions and aberrant RNA splicing in mice.
Posttranslational modification of SR proteins underlies the regulation of their mRNA export activities and distinguishes pluripotent from differentiated cells.
Title: Cellular differentiation state modulates the mRNA export activity of SR proteins.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11Wsu175e (e-PCR), detects polymorphism
- UniSTS:141827

Sfrs2 (e-PCR), detects polymorphism
- UniSTS:479264

UniSTS:479265 (e-PCR)
- UniSTS:479265

Sfrs2 (e-PCR), detects polymorphism
- UniSTS:479265

D4S2570E (e-PCR)
- UniSTS:58217

Sfrs2 (e-PCR), detects polymorphism
- UniSTS:463224

Sfrs2 (e-PCR), detects polymorphism
- UniSTS:526982

UniSTS:275635 (e-PCR)
- UniSTS:275635

Sfrs2 (e-PCR), detects polymorphism
- UniSTS:275635

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables pre-mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase C binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA splicing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of alternative mRNA splicing, via spliceosome	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in interchromatin granule	ISO Inferred from Sequence Orthology more info
is_active_in nuclear speck	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear speck	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear speck	ISO Inferred from Sequence Orthology more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perichromatin fibrils	ISO Inferred from Sequence Orthology more info
part_of spliceosomal complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: serine/arginine-rich splicing factor 2

Names: myelin regulatory factor 1; putative myelin regulatory factor 1; splicing component, 35 kDa; splicing factor Sc35; splicing factor, arginine/serine-rich 2 (SC-35)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011358.2 → NP_035488.1 serine/arginine-rich splicing factor 2

See identical proteins and their annotated locations for NP_035488.1

Status: REVIEWED

Source sequence(s)

AK086103, BG093253, CJ043688

Consensus CDS

CCDS25680.1

UniProtKB/Swiss-Prot

Q542L3, Q60701, Q62093

Related

ENSMUSP00000090059.7, ENSMUST00000092404.13

Conserved Domains (1) summary

cd12311
Location:16 → 88

RRM_SRSF2_SRSF8; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor SRSF2, SRSF8 and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

116740723..116744511 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030245724.2 → XP_030101584.1 serine/arginine-rich splicing factor 2 isoform X1

UniProtKB/Swiss-Prot

Q542L3, Q60701, Q62093

Conserved Domains (1) summary

cd12311
Location:16 → 88

RRM_SRSF2_SRSF8; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor SRSF2, SRSF8 and similar proteins
XM_011248835.4 → XP_011247137.1 serine/arginine-rich splicing factor 2 isoform X1

See identical proteins and their annotated locations for XP_011247137.1

UniProtKB/Swiss-Prot

Q542L3, Q60701, Q62093

Conserved Domains (1) summary

cd12311
Location:16 → 88

RRM_SRSF2_SRSF8; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor SRSF2, SRSF8 and similar proteins