Gucy1a1 guanylate cyclase 1, soluble, alpha 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gucy1a1provided by MGI
Official Full Name: guanylate cyclase 1, soluble, alpha 1provided by MGI
Primary source: MGI:MGI:1926562
See related: Ensembl:ENSMUSG00000033910 AllianceGenome:MGI:1926562
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gucy1a3; sGC-alpha1; GCS-alpha-1; GCS-alpha-3; 1200016O07Rik
Summary: Predicted to enable guanylate cyclase activity and ion binding activity. Predicted to contribute to adenylate cyclase activity and cytidylate cyclase activity. Involved in retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission. Acts upstream of or within several processes, including cGMP biosynthetic process; positive regulation of nitric oxide mediated signal transduction; and relaxation of vascular associated smooth muscle. Located in GABA-ergic synapse and glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skeleton. Used to study primary open angle glaucoma. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to human GUCY1A1 (guanylate cyclase 1 soluble subunit alpha 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in lung adult (RPKM 25.7), CNS E18 (RPKM 15.8) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 E3; 3 35.97 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (81999734..82053253, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (82092427..82145946, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of Gucy1a3 causes poor post-stroke recovery by reducing angiogenesis via the HIF-1alpha/VEGFA signaling pathway in mice.
Title: Loss of Gucy1a3 causes poor post-stroke recovery by reducing angiogenesis via the HIF-1α/VEGFA signaling pathway in mice.
Hydrogen sulfide regulates the redox state of soluble guanylate cyclase in CSE[-/-] mice corpus cavernosum microcirculation.
Title: Hydrogen sulfide regulates the redox state of soluble guanylate cyclase in CSE(-/-) mice corpus cavernosum microcirculation.
Repurposing Riociguat to Target a Novel Paracrine Nitric Oxide-TRPC6 Pathway to Prevent Podocyte Injury.
Title: Repurposing Riociguat to Target a Novel Paracrine Nitric Oxide-TRPC6 Pathway to Prevent Podocyte Injury.
These studies identify MEK/ERK signaling as an important pathway by which TGFbeta regulates sGC expression in pulmonary artery smooth muscle cell.
Title: Transforming growth factor-β downregulates sGC subunit expression in pulmonary artery smooth muscle cells via MEK and ERK signaling.
Study shows notch signaling provides a constitutive drive on expression of the major nitric oxide receptor GUCY1A3 and GUCY1B3 in arteries from mice.
Title: Hypertension reduces soluble guanylyl cyclase expression in the mouse aorta via the Notch signaling pathway.
Exogenous or paracrine sources of NO promote the specification towards the myocyte lineage and expression of cardiac sarcomeric proteins of adult cardiac progenitor cells. This is contingent upon the expression and activity of the alpha1 subunit of guanylyl cyclase in CPC that is necessary for NO-mediated inhibition of the canonical Wnt/beta-catenin pathway.
Title: Paracrine nitric oxide induces expression of cardiac sarcomeric proteins in adult progenitor cells through soluble guanylyl cyclase/cyclic-guanosine monophosphate and Wnt/β-catenin inhibition.
These data demonstrate that a reduction in cardiac sGC activity worsens doxorubicin-induced cardiotoxicity in mice and identify sGC as a potential therapeutic target.
Title: Decreased Soluble Guanylate Cyclase Contributes to Cardiac Dysfunction Induced by Chronic Doxorubicin Treatment in Mice.
We suggest that Gucy1a3 activity promotes the phenotypic switching of smooth muscle cells from a contractile to a synthetic state, fostering the formation of atherosclerosis.
Title: Proatherosclerotic Effect of the α1-Subunit of Soluble Guanylyl Cyclase by Promoting Smooth Muscle Phenotypic Switching.
The authors elucidated this dependency by showing that guanylate cyclase-1 is a novel rhodopsin-binding protein.
Title: Guanylate cyclase 1 relies on rhodopsin for intracellular stability and ciliary trafficking.
Cellular markers revealed that vascular SMC differentiation decreased, whereas myofibroblast activation increased in the hyperoxic sGC-alpha1 KO pup lung.
Title: Soluble guanylate cyclase modulates alveolarization in the newborn lung.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (3) 1 citation

General gene information

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Markers

Gucy1a3 (e-PCR), detects polymorphism
- UniSTS:506963

Gucy1a3 (e-PCR), detects polymorphism
- UniSTS:525449

fl05f06.x1 (e-PCR)
- UniSTS:201902

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
contributes_to adenylate cyclase activity	ISO Inferred from Sequence Orthology more info
contributes_to cytidylate cyclase activity	ISO Inferred from Sequence Orthology more info
enables guanylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanylate cyclase activity	ISO Inferred from Sequence Orthology more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables ion binding	ISO Inferred from Sequence Orthology more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables phosphorus-oxygen lyase activity	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cGMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cGMP biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cGMP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cGMP-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cyclic nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of nitric oxide mediated signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nitric oxide-cGMP-mediated signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of nitric oxide mediated signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within relaxation of vascular associated smooth muscle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxygen levels	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in GABA-ergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
part_of guanylate cyclase complex, soluble	IBA Inferred from Biological aspect of Ancestor more info
part_of guanylate cyclase complex, soluble	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in synapse	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: guanylate cyclase soluble subunit alpha-1

Names: guanylate cyclase 1, soluble, alpha 3; guanylate cyclase soluble subunit alpha-3; soluble guanylate cyclase large subunit

NP_001343916.1

EC 4.6.1.2

NP_001343917.1

EC 4.6.1.2

NP_068696.2

EC 4.6.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001356987.1 → NP_001343916.1 guanylate cyclase soluble subunit alpha-1

Status: VALIDATED

Source sequence(s)

AC121563, BC094310, CO042590

Consensus CDS

CCDS17429.1

UniProtKB/Swiss-Prot

Q6GTG0, Q9DBQ3, Q9ERL9

Related

ENSMUSP00000142138.2, ENSMUST00000193924.6

Conserved Domains (2) summary

pfam00211
Location:472 → 643

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam07701
Location:277 → 466

HNOBA; Heme NO binding associated
NM_001356988.1 → NP_001343917.1 guanylate cyclase soluble subunit alpha-1

Status: VALIDATED

Source sequence(s)

AC121563, CO042590

Consensus CDS

CCDS17429.1

UniProtKB/Swiss-Prot

Q6GTG0, Q9DBQ3, Q9ERL9

Conserved Domains (2) summary

pfam00211
Location:472 → 643

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam07701
Location:277 → 466

HNOBA; Heme NO binding associated
NM_021896.6 → NP_068696.2 guanylate cyclase soluble subunit alpha-1

See identical proteins and their annotated locations for NP_068696.2

Status: VALIDATED

Source sequence(s)

AC121563, AK004815, BC057327, BY150724, CO042590

Consensus CDS

CCDS17429.1

UniProtKB/Swiss-Prot

Q6GTG0, Q9DBQ3, Q9ERL9

Related

ENSMUSP00000048918.7, ENSMUST00000048976.8

Conserved Domains (2) summary

pfam00211
Location:472 → 643

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam07701
Location:277 → 466

HNOBA; Heme NO binding associated