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    Clec18a C-type lectin domain family 18, member A [ Mus musculus (house mouse) ]

    Gene ID: 353287, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Clec18aprovided by MGI
    Official Full Name
    C-type lectin domain family 18, member Aprovided by MGI
    Primary source
    MGI:MGI:2672935
    See related
    Ensembl:ENSMUSG00000033633 AllianceGenome:MGI:2672935
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mrcl
    Summary
    Predicted to enable polysaccharide binding activity. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to several human genes including CLEC18B (C-type lectin domain family 18 member B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cortex adult (RPKM 1.7), frontal lobe adult (RPKM 1.2) and 9 other tissues See more
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    Genomic context

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    Location:
    8 E1; 8 57.93 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (111796128..111819056, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (111069496..111092424, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene alanyl-tRNA synthetase 1 Neighboring gene predicted gene, 38523 Neighboring gene nuclear encoded tRNA glycine 2 (anticodon GCC) Neighboring gene exosome component 6 Neighboring gene pyruvate dehydrogenase phosphatase regulatory subunit Neighboring gene RIKEN cDNA 9430091E24 gene Neighboring gene golgi apparatus protein 1 Neighboring gene STARR-seq mESC enhancer starr_22692 Neighboring gene STARR-positive B cell enhancer ABC_E708 Neighboring gene predicted gene, 53455

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Endosomal TLR3 co-receptor CLEC18A enhances host immune response to viral infection. Huang YL, et al. Commun Biol, 2021 Feb 18. PMID 33603190, Free PMC Article
    2. The mannose receptor mediates uptake of soluble but not of cell-associated antigen for cross-presentation. Burgdorf S, et al. J Immunol, 2006 Jun 1. PMID 16709836
    3. Comparison of the gene expression profiles from normal and Fgfrl1 deficient mouse kidneys reveals downstream targets of Fgfrl1 signaling. Gerber SD, et al. PLoS One, 2012. PMID 22432025, Free PMC Article
    4. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Endosomal TLR3 co-receptor CLEC18A enhances host immune response to viral infection.
      Title: Endosomal TLR3 co-receptor CLEC18A enhances host immune response to viral infection.
    2. Dendritic cells use the mannose receptor for endocytosis of a particular antigen type (soluble ovalbumin) intended for cross-presentation.
      Title: The mannose receptor mediates uptake of soluble but not of cell-associated antigen for cross-presentation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (3) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables polysaccharide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polysaccharide binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    C-type lectin domain family 18 member A
    Names
    mannose receptor-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001402947.1 → NP_001389876.1  C-type lectin domain family 18 member A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC093451

    2. NM_181549.4 → NP_853527.2  C-type lectin domain family 18 member A isofomr 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC093451
      UniProtKB/TrEMBL
      A0A087WP55
      Related
      ENSMUSP00000141073.2, ENSMUST00000188466.7
      Conserved Domains (2) summary
      cd00037
      Location:316 → 440
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
      cd05380
      Location:55 → 189
      SCP_euk; SCP_euk: SCP-like extracellular protein domain, as found mainly in eukaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5 from vespid venom. It has been proposed ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      111796128..111819056 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248418.2 → XP_011246720.1  C-type lectin domain family 18 member A isoform X6

      Conserved Domains (2) summary
      cd00037
      Location:390 → 514
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
      cd05380
      Location:129 → 263
      CAP_euk; Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins

    2. XM_006531143.3 → XP_006531206.3  C-type lectin domain family 18 member A isoform X7

      UniProtKB/TrEMBL
      A0A087WP55
      Related
      ENSMUSP00000139569.2, ENSMUST00000191030.7
      Conserved Domains (2) summary
      cd00037
      Location:368 → 492
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
      cd05380
      Location:107 → 241
      CAP_euk; Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins

    3. XM_030243639.2 → XP_030099499.1  C-type lectin domain family 18 member A isoform X3

      Conserved Domains (3) summary
      cd00037
      Location:359 → 483
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
      cd00054
      Location:305 → 341
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd05380
      Location:129 → 263
      CAP_euk; Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins

    4. XM_030243637.2 → XP_030099497.1  C-type lectin domain family 18 member A isoform X1

      Conserved Domains (3) summary
      cd00037
      Location:390 → 514
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
      smart00180
      Location:315 → 360
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      cd05380
      Location:129 → 263
      CAP_euk; Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins

    5. XM_030243641.2 → XP_030099501.1  C-type lectin domain family 18 member A isoform X5

      Conserved Domains (2) summary
      cd00037
      Location:337 → 461
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
      cd05380
      Location:76 → 210
      CAP_euk; Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins

    6. XM_030243638.2 → XP_030099498.1  C-type lectin domain family 18 member A isoform X2

      Conserved Domains (3) summary
      cd00037
      Location:368 → 492
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
      smart00180
      Location:293 → 338
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      cd05380
      Location:107 → 241
      CAP_euk; Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins

    7. XM_030243642.2 → XP_030099502.1  C-type lectin domain family 18 member A isoform X8

      Conserved Domains (2) summary
      cd00037
      Location:243 → 367
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
      cd05380
      Location:1 → 116
      CAP_euk; Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins

    8. XM_030243640.2 → XP_030099500.1  C-type lectin domain family 18 member A isoform X4

      UniProtKB/Swiss-Prot
      Q7TMA7, Q7TSP9, Q7TSQ0, Q7TSQ1, Q7TSQ7
      Conserved Domains (2) summary
      cd00037
      Location:341 → 465
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
      cd05380
      Location:80 → 214
      CAP_euk; Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins

    9. XM_011248419.2 → XP_011246721.1  C-type lectin domain family 18 member A isoform X9

      UniProtKB/TrEMBL
      A0A087WP55
      Conserved Domains (1) summary
      cd05380
      Location:129 → 263
      CAP_euk; Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TSQ1.1 GenPept UniProtKB/Swiss-Prot:Q7TSQ1

    Gene LinkOut

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