Casp4 caspase 4, apoptosis-related cysteine peptidase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Casp4provided by MGI
Official Full Name: caspase 4, apoptosis-related cysteine peptidaseprovided by MGI
Primary source: MGI:MGI:107700
See related: Ensembl:ENSMUSG00000033538 AllianceGenome:MGI:107700
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Caspl; ich-3; CASP-4; Casp11; CASP-11
Summary: This gene encodes a member of the cysteine proteases that plays important roles in apoptosis, cell migration and the inflammatory response. The encoded protein mediates production of pro-inflammatory cytokines by macrophages upon bacterial infection. Mice lacking the encoded protein are resistant to endotoxic shock induced by lipopolysaccharide. A 5-bp deletion encompassing a splice acceptor junction resulting in alternate splicing and a shorter non-functional isoform in certain mouse strains has been described. Although its official nomenclature is "caspase 4, apoptosis-related cysteine peptidase", this gene and its encoded protein have historically been called caspase 11. This gene is present in a cluster of three caspase genes on chromosome 9. [provided by RefSeq, Apr 2015]
Expression: Biased expression in large intestine adult (RPKM 7.7), bladder adult (RPKM 4.0) and 14 other tissues See more
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Genomic context

Location:: 9 A1; 9 2.46 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (5308816..5336791)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (5308849..5336791)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Downregulation of HMGB1 carried by macrophage-derived extracellular vesicles delays atherosclerotic plaque formation through Caspase-11-dependent macrophage pyroptosis.
Title: Downregulation of HMGB1 carried by macrophage-derived extracellular vesicles delays atherosclerotic plaque formation through Caspase-11-dependent macrophage pyroptosis.
Dectin-1 aggravates neutrophil inflammation through caspase-11/4-mediated macrophage pyroptosis in asthma.
Title: Dectin-1 aggravates neutrophil inflammation through caspase-11/4-mediated macrophage pyroptosis in asthma.
DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates inflammation and amyloid-beta deposition in Alzheimer's disease.
Title: DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates inflammation and amyloid-β deposition in Alzheimer's disease.
Catalytic activity and autoprocessing of murine caspase-11 mediate noncanonical inflammasome assembly in response to cytosolic LPS.
Title: Catalytic activity and autoprocessing of murine caspase-11 mediate noncanonical inflammasome assembly in response to cytosolic LPS.
LincRNA-EPS inhibits caspase-11 and NLRP3 inflammasomes in gingival fibroblasts to alleviate periodontal inflammation.
Title: LincRNA-EPS inhibits caspase-11 and NLRP3 inflammasomes in gingival fibroblasts to alleviate periodontal inflammation.
Caspase-11 deficiency attenuates neutrophil recruitment into the atherosclerotic lesion in apolipoprotein E-deficient mice.
Title: Caspase-11 deficiency attenuates neutrophil recruitment into the atherosclerotic lesion in apolipoprotein E-deficient mice.
High Lethality of Mycobacterium tuberculosis Infection in Mice Lacking the Phagocyte Oxidase and Caspase1/11.
Title: High Lethality of Mycobacterium tuberculosis Infection in Mice Lacking the Phagocyte Oxidase and Caspase1/11.
Ghrelin protects against ischemia/reperfusion-induced hepatic injury via inhibiting Caspase-11-mediated noncanonical pyroptosis.
Title: Ghrelin protects against ischemia/reperfusion-induced hepatic injury via inhibiting Caspase-11-mediated noncanonical pyroptosis.
Caspase-4 dimerisation and D289 auto-processing elicit an interleukin-1beta-converting enzyme.
Title: Caspase-4 dimerisation and D289 auto-processing elicit an interleukin-1β-converting enzyme.
Cytosolic LPS-induced caspase-11 oligomerization and activation is regulated by extended synaptotagmin 1.
Title: Cytosolic LPS-induced caspase-11 oligomerization and activation is regulated by extended synaptotagmin 1.

Submit: New GeneRIF Correction See all GeneRIFs (109)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1) 1 citation
Targeted (7) 1 citation
Endonuclease-mediated (6) 1 citation

General gene information

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Markers

px-35d2 (e-PCR)
- UniSTS:257633

Casp4 (e-PCR), detects polymorphism
- UniSTS:259201

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables CARD domain binding	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type endopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
NOT enables cysteine-type endopeptidase activity involved in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables lipid binding	IDA Inferred from Direct Assay more info	PubMed
enables lipid binding	ISO Inferred from Sequence Orthology more info
enables lipopolysaccharide binding	IDA Inferred from Direct Assay more info	PubMed
enables lipopolysaccharide binding	ISO Inferred from Sequence Orthology more info
enables peptidase activity	RCA inferred from Reviewed Computational Analysis more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin filament organization	TAS Traceable Author Statement more info	PubMed
NOT involved_in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to Gram-positive bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within ectopic germ cell programmed cell death	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within ectopic germ cell programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of interleukin-1 beta production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of macrophage cytokine production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in non-canonical inflammasome complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in non-canonical inflammasome complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of NLRP3 inflammasome complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of interleukin-1 beta production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of interleukin-18-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of macrophage cytokine production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of neuron apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within programmed cell death	IEA Inferred from Electronic Annotation more info
involved_in protein autoprocessing	IDA Inferred from Direct Assay more info	PubMed
involved_in protein autoprocessing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein maturation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within proteolysis	RCA inferred from Reviewed Computational Analysis more info	PubMed
involved_in pyroptosis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within pyroptosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pyroptosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of inflammatory response	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of NLRP1 inflammasome complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NLRP1 inflammasome complex	ISO Inferred from Sequence Orthology more info
part_of canonical inflammasome complex	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
part_of non-canonical inflammasome complex	IDA Inferred from Direct Assay more info	PubMed
part_of non-canonical inflammasome complex	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: caspase-4

Names: caspase 11, apoptosis-related cysteine peptidase; caspase 11, apoptosis-related cysteine protease; caspase 4, apoptosis-related cysteine protease; caspase-11 short form splicing; protease ICH-3

NP_001366247.1

EC 3.4.22.64

NP_001366248.1

EC 3.4.22.64

NP_001366249.1

EC 3.4.22.64

NP_001366250.1

EC 3.4.22.64

NP_001366251.1

EC 3.4.22.64

NP_001366252.1

EC 3.4.22.64

NP_031635.2

EC 3.4.22.64

XP_006509902.1

EC 3.4.22.64

XP_036010472.1

EC 3.4.22.64

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001379318.1 → NP_001366247.1 caspase-4 isoform 2

Status: REVIEWED

Source sequence(s)

AC141637

Conserved Domains (2) summary

smart00115
Location:66 → 315

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

cl14633
Location:1 → 29

DD; Death Domain Superfamily of protein-protein interaction domains
NM_001379319.1 → NP_001366248.1 caspase-4 isoform 3

Status: REVIEWED

Source sequence(s)

AC141637

Conserved Domains (1) summary

smart00115
Location:5 → 254

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
NM_001379320.1 → NP_001366249.1 caspase-4 isoform 4

Status: REVIEWED

Source sequence(s)

AC141637

Conserved Domains (2) summary

smart00115
Location:122 → 370

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

cd08325
Location:5 → 85

CARD_CASP1-like; Caspase activation and recruitment domain found in Caspase-1 and related proteins
NM_001379321.1 → NP_001366250.1 caspase-4 isoform 5

Status: REVIEWED

Source sequence(s)

AC141637

Conserved Domains (1) summary

cl00042
Location:3 → 196

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
NM_001379322.1 → NP_001366251.1 caspase-4 isoform 6

Status: REVIEWED

Source sequence(s)

AC141637

Conserved Domains (1) summary

smart00115
Location:5 → 253

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
NM_001379323.1 → NP_001366252.1 caspase-4 isoform 7

Status: REVIEWED

Source sequence(s)

AC141637

Conserved Domains (1) summary

smart00115
Location:42 → 291

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
NM_007609.3 → NP_031635.2 caspase-4 isoform 1

See identical proteins and their annotated locations for NP_031635.2

Status: REVIEWED

Source sequence(s)

AC141637, AK151547

Consensus CDS

CCDS22799.1

UniProtKB/Swiss-Prot

C6L648, O08735, P70343, Q3TAF3, Q6P8H1

Related

ENSMUSP00000027012.8, ENSMUST00000027012.14

Conserved Domains (2) summary

smart00115
Location:122 → 371

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

cd08325
Location:5 → 85

CARD_CASP1-like; Caspase activation and recruitment domain found in Caspase-1 and related proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

5308816..5336791

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036154579.1 → XP_036010472.1 caspase-4 isoform X1

Conserved Domains (2) summary

cd08325
Location:28 → 108

CARD_CASP1-like; Caspase activation and recruitment domain found in Caspase-1 and related proteins

cl00042
Location:145 → 327

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
XM_006509839.2 → XP_006509902.1 caspase-4 isoform X2

See identical proteins and their annotated locations for XP_006509902.1

Conserved Domains (1) summary

smart00115
Location:5 → 254

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues