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    Acsm1 acyl-CoA synthetase medium-chain family member 1 [ Mus musculus (house mouse) ]

    Gene ID: 117147, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Acsm1provided by MGI
    Official Full Name
    acyl-CoA synthetase medium-chain family member 1provided by MGI
    Primary source
    MGI:MGI:2152200
    See related
    Ensembl:ENSMUSG00000033533 AllianceGenome:MGI:2152200
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Macs; Acas3; Bucs1
    Summary
    Enables benzoate-CoA ligase activity; butyrate-CoA ligase activity; and decanoate-CoA ligase activity. Acts upstream of or within fatty acid biosynthetic process. Located in mitochondrion. Is expressed in lung and urinary system. Orthologous to human ACSM1 (acyl-CoA synthetase medium chain family member 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver adult (RPKM 94.8), kidney adult (RPKM 81.4) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 F2; 7 64.02 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (119217035..119261738)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (119617757..119662515)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene acyl-CoA synthetase medium-chain family member 2 Neighboring gene predicted gene, 39078 Neighboring gene predicted gene, 39079 Neighboring gene STARR-seq mESC enhancer starr_20036 Neighboring gene acyl-CoA synthetase medium-chain family member 4 Neighboring gene THUMP domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. O-MACS, a novel member of the medium-chain acyl-CoA synthetase family, specifically expressed in the olfactory epithelium in a zone-specific manner. Oka Y, et al. Eur J Biochem, 2003 May. PMID 12709059
    2. Molecular identification and characterization of two medium-chain acyl-CoA synthetases, MACS1 and the Sa gene product. Fujino T, et al. J Biol Chem, 2001 Sep 21. PMID 11470804
    3. The miR-379/miR-410 cluster at the imprinted Dlk1-Dio3 domain controls neonatal metabolic adaptation. Labialle S, et al. EMBO J, 2014 Oct 1. PMID 25124681, Free PMC Article
    4. Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways. Thiagarajan RD, et al. PLoS One, 2011 Feb 28. PMID 21386911, Free PMC Article
    5. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables benzoate-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables benzoate-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables butyrate-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables butyrate-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables butyrate-CoA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables decanoate-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables decanoate-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables fatty acid ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty acid ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables fatty-acyl-CoA synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables long-chain fatty acid-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables long-chain fatty acid-CoA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables medium-chain fatty acid-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in acyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within fatty acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    acyl-coenzyme A synthetase ACSM1, mitochondrial
    Names
    acetyl-Coenzyme A synthetase 3
    benzoate--CoA ligase
    butyrate--CoA ligase 1
    butyryl Coenzyme A synthetase 1
    butyryl-coenzyme A synthetase 1
    lipoate-activating enzyme
    middle-chain acyl-CoA synthetase 1
    NP_001407267.1
    NP_001407268.1
    NP_473435.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001420338.1 → NP_001407267.1  acyl-coenzyme A synthetase ACSM1, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC134587

    2. NM_001420339.1 → NP_001407268.1  acyl-coenzyme A synthetase ACSM1, mitochondrial isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC134587

    3. NM_054094.6 → NP_473435.1  acyl-coenzyme A synthetase ACSM1, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_473435.1

      Status: VALIDATED

      Source sequence(s)
      AC134587
      Consensus CDS
      CCDS21783.1
      UniProtKB/Swiss-Prot
      Q3UED4, Q91VA0
      UniProtKB/TrEMBL
      D3Z106
      Related
      ENSMUSP00000036140.7, ENSMUST00000047929.13
      Conserved Domains (1) summary
      cl17068
      Location:42 → 569
      AFD_class_I; Adenylate forming domain, Class I superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      119217035..119261738
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91VA0.1 GenPept UniProtKB/Swiss-Prot:Q91VA0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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