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    Tomm6 translocase of outer mitochondrial membrane 6 [ Mus musculus (house mouse) ]

    Gene ID: 66119, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Tomm6provided by MGI
    Official Full Name
    translocase of outer mitochondrial membrane 6provided by MGI
    Primary source
    MGI:MGI:1913369
    See related
    Ensembl:ENSMUSG00000033475 AllianceGenome:MGI:1913369
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110002E23Rik
    Summary
    Predicted to act upstream of or within protein transport. Located in mitochondrion. Is expressed in several structures, including central nervous system; genitourinary system; gut; sensory organ; and thymus. Orthologous to human TOMM6 (translocase of outer mitochondrial membrane 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 33.4), stomach adult (RPKM 30.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 C; 17 23.87 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (47997570..47999311, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (47686645..47688386, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene cyclin D3 Neighboring gene STARR-positive B cell enhancer ABC_E9169 Neighboring gene bystin-like Neighboring gene predicted gene 20517 Neighboring gene STARR-positive B cell enhancer ABC_E10959 Neighboring gene mediator complex subunit 20 Neighboring gene Kpna2 retrotransposed pseudogene Neighboring gene ubiquitin specific peptidase 49 Neighboring gene STARR-positive B cell enhancer ABC_E4218 Neighboring gene prickle planar cell polarity protein 4 Neighboring gene translocase of outer mitochondrial membrane 6, opposite strand Neighboring gene fibroblast growth factor receptor substrate 3 Neighboring gene fibroblast growth factor receptor substrate 3, opposite strand

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus. Chung YC, et al. Gene Expr Patterns, 2011 Jan-Feb. PMID 20932939
    2. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
    3. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mitochondrial outer membrane translocase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial import receptor subunit TOM6 homolog
    Names
    overexpressed breast tumor protein homolog
    translocase of outer membrane 6 kDa subunit homolog
    translocase of outer mitochondrial membrane 6 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164729.1 → NP_001158201.1  mitochondrial import receptor subunit TOM6 homolog

      See identical proteins and their annotated locations for NP_001158201.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC089325, CA319049, CA321392
      Consensus CDS
      CCDS37643.1
      UniProtKB/Swiss-Prot
      Q9CQN3
      Related
      ENSMUSP00000108926.2, ENSMUST00000113301.2
      Conserved Domains (1) summary
      pfam15184
      Location:1 → 74
      TOM6p; Mitochondrial import receptor subunit TOM6 homolog

    2. NM_025365.3 → NP_079641.1  mitochondrial import receptor subunit TOM6 homolog

      See identical proteins and their annotated locations for NP_079641.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK010470, BC089325, CA321392
      Consensus CDS
      CCDS37643.1
      UniProtKB/Swiss-Prot
      Q9CQN3
      Related
      ENSMUSP00000108927.4, ENSMUST00000113302.10
      Conserved Domains (1) summary
      pfam15184
      Location:1 → 74
      TOM6p; Mitochondrial import receptor subunit TOM6 homolog

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      47997570..47999311 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQN3.1 GenPept UniProtKB/Swiss-Prot:Q9CQN3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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