Cysltr2 cysteinyl leukotriene receptor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cysltr2provided by MGI
Official Full Name: cysteinyl leukotriene receptor 2provided by MGI
Primary source: MGI:MGI:1917336
See related: Ensembl:ENSMUSG00000033470 AllianceGenome:MGI:1917336
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cltr2; Cyslt2; CYSLT2R; 2300001H05Rik
Summary: Enables cysteinyl leukotriene receptor activity. Predicted to be involved in several processes, including neuropeptide signaling pathway; positive regulation of ERK1 and ERK2 cascade; and positive regulation of angiogenesis. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Located in membrane. Human ortholog(s) of this gene implicated in aspirin-induced respiratory disease and asthma. Orthologous to human CYSLTR2 (cysteinyl leukotriene receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in thymus adult (RPKM 1.4), spleen adult (RPKM 0.4) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 D3; 14 38.54 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (73263043..73286554, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (73025672..73049114, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The CysLT2R receptor mediates leukotriene C4-driven acute and chronic itch.
Title: The CysLT(2)R receptor mediates leukotriene C(4)-driven acute and chronic itch.
this study shows that cysteinyl leukotriene receptor 2 drives lung immunopathology through a platelet and high mobility box 1-dependent mechanism
Title: Cysteinyl leukotriene receptor 2 drives lung immunopathology through a platelet and high mobility box 1-dependent mechanism.
CysLT2 receptors were constitutively expressed in the lung, and expression was strengthened in asthmatic mice. Activation of CysLT2 receptors was functionally involved in allergic leukocyte infiltration into the lung.
Title: Increased expression of CysLT(2) receptors in the lung of asthmatic mice and role in allergic responses.
CysLT2R signaling, IL-33-dependent group 2 innate lymphoid cell expansion, and IL-33-driven mast cell activation are necessary for induction of type 2 immunopathology and aspirin sensitivity. CysLT2R-targeted drugs may interrupt these processes.
Title: Type 2 Cysteinyl Leukotriene Receptors Drive IL-33-Dependent Type 2 Immunopathology and Aspirin Sensitivity.
It plays a critical role in Ab1e42-induced neurotoxicity.
Title: Involvement of cysteinyl leukotriene receptor 1 in Aβ1-42-induced neurotoxicity in vitro and in vivo.
The CysLT(1) and CysLT(2) receptors were primarily localized in neurons, microglia and neutrophils
Title: Aggravated inflammation and increased expression of cysteinyl leukotriene receptors in the brain after focal cerebral ischemia in AQP4-deficient mice.
Suggest that endothelial and nonendothelial CysLT2R niches have separate roles in mediating inflammatory responses in ischemic/perfusion injury.
Title: Multiple-site activation of the cysteinyl leukotriene receptor 2 is required for exacerbation of ischemia/reperfusion injury.
LTC4 activates mouse platelets exclusively through CysLT2R. LTC4/CysLT2R signaling required an autocrine ADP-mediated response through P2Y12 receptors.
Title: Cutting edge: Leukotriene C4 activates mouse platelets in plasma exclusively through the type 2 cysteinyl leukotriene receptor.
CysLT1R, CysLT2R and GPR17 might be involved in the MPTP-induced Parkinson disease damage in mice.
Title: [Expression and distribution of cysteinyl leukotriene receptors CysLT1R and CysLT2R, and GPR17 in brain of Parkinson disease model mice].
CysLT2R negatively regulates the development of cys-LT-dependent T helper cell (Th)2 pulmonary inflammation by inhibiting both CysLT1R signaling and house dust mite-induced LTC4S-dependent cell surface expression of CysLT1R on dendritic cells.
Title: Cysteinyl leukotriene 2 receptor on dendritic cells negatively regulates ligand-dependent allergic pulmonary inflammation.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (7)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables cysteinyl leukotriene receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteinyl leukotriene receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables leukotriene receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of glial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cysteinyl leukotriene receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001162412.2 → NP_001155884.1 cysteinyl leukotriene receptor 2

See identical proteins and their annotated locations for NP_001155884.1

Status: VALIDATED

Source sequence(s)

AC155237, CT571265

Consensus CDS

CCDS27265.1

UniProtKB/Swiss-Prot

A2RT90, Q920A1

UniProtKB/TrEMBL

Q8R528

Related

ENSMUSP00000125958.2, ENSMUST00000169168.3

Conserved Domains (2) summary

cd14964
Location:25 → 49

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:23 → 300

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
NM_133720.4 → NP_598481.2 cysteinyl leukotriene receptor 2

See identical proteins and their annotated locations for NP_598481.2

Status: VALIDATED

Source sequence(s)

AC155237, CT571265

Consensus CDS

CCDS27265.1

UniProtKB/Swiss-Prot

A2RT90, Q920A1

UniProtKB/TrEMBL

Q8R528

Related

ENSMUSP00000040715.5, ENSMUST00000044664.12

Conserved Domains (2) summary

cd14964
Location:25 → 49

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:23 → 300

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

73263043..73286554 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030248001.2 → XP_030103861.1 cysteinyl leukotriene receptor 2 isoform X1

UniProtKB/Swiss-Prot

A2RT90, Q920A1

UniProtKB/TrEMBL

Q8R528

Conserved Domains (2) summary

cd14964
Location:25 → 49

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:23 → 300

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily