Duox1 dual oxidase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Duox1provided by MGI
Official Full Name: dual oxidase 1provided by MGI
Primary source: MGI:MGI:2139422
See related: Ensembl:ENSMUSG00000033268 AllianceGenome:MGI:2139422
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Duox2; LNOX1; LNOX2; THOX1; THOX2; NOXEF1; NOXEF2; P138-TOX; 9930101G15Rik
Summary: Predicted to enable superoxide-generating NAD(P)H oxidase activity. Acts upstream of or within reactive oxygen species metabolic process. Located in plasma membrane. Is expressed in brain; placenta; and thyroid gland. Orthologous to human DUOX1 (dual oxidase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in stomach adult (RPKM 3.3), bladder adult (RPKM 2.4) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E5; 2 60.63 cM

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (122143525..122178454)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (122313010..122347972)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dual oxidase 1 is dispensable during Mycobacterium tuberculosis infection in mice.
Title: Dual oxidase 1 is dispensable during Mycobacterium tuberculosis infection in mice.
Diet-induced obesity worsens allergen-induced type 2/type 17 inflammation in airways by enhancing DUOX1 activation.
Title: Diet-induced obesity worsens allergen-induced type 2/type 17 inflammation in airways by enhancing DUOX1 activation.
Oxidation-Dependent Activation of Src Kinase Mediates Epithelial IL-33 Production and Signaling during Acute Airway Allergen Challenge.
Title: Oxidation-Dependent Activation of Src Kinase Mediates Epithelial IL-33 Production and Signaling during Acute Airway Allergen Challenge.
Dual oxidase 1 promotes antiviral innate immunity.
Title: Dual oxidase 1 promotes antiviral innate immunity.
Downregulation of DUOX1 function contributes to aging-related impairment of innate airway injury responses and accelerated senile emphysema.
Title: Downregulation of DUOX1 function contributes to aging-related impairment of innate airway injury responses and accelerated senile emphysema.
NADPH oxidase DUOX1 sustains TGF-beta1 signalling and promotes lung fibrosis.
Title: NADPH oxidase DUOX1 sustains TGF-β1 signalling and promotes lung fibrosis.
Downregulation of epithelial DUOX1 in chronic obstructive pulmonary disease.
Title: Downregulation of epithelial DUOX1 in chronic obstructive pulmonary disease.
Structures of mouse DUOX1-DUOXA1 provide mechanistic insights into enzyme activation and regulation.
Title: Structures of mouse DUOX1-DUOXA1 provide mechanistic insights into enzyme activation and regulation.
this study shows that Duox1 regulates primary B cell function under the influence of IL-4 through BCR-mediated generation of hydrogen peroxide
Title: Duox1 Regulates Primary B Cell Function under the Influence of IL-4 through BCR-Mediated Generation of Hydrogen Peroxide.
Cigarette smoke impairs A2A adenosine receptor mediated wound repair through up-regulation of Duox-1 expression.
Title: Cigarette Smoke Impairs A(2A) Adenosine Receptor Mediated Wound Repair through Up-regulation of Duox-1 Expression.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (1)
Chemically induced (ENU) (2) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

Duox1 (e-PCR), detects polymorphism
- UniSTS:462682

AW987690 (e-PCR)
- UniSTS:185493

Duox1 (e-PCR), detects polymorphism
- UniSTS:546745

Duox1 (e-PCR), detects polymorphism
- UniSTS:525521

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NAD(P)H oxidase H2O2-forming activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables superoxide-generating NAD(P)H oxidase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cuticle development	ISO Inferred from Sequence Orthology more info
involved_in cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in defense response	IBA Inferred from Biological aspect of Ancestor more info
involved_in hydrogen peroxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell motility	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of wound healing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within reactive oxygen species metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to cAMP	ISO Inferred from Sequence Orthology more info
involved_in superoxide anion generation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of NADPH oxidase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cell leading edge	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dual oxidase 1

Names: dual oxidase 2

NP_001092767.1

EC 1.6.3.1

XP_006500550.1

EC 1.6.3.1

XP_030108139.1

EC 1.6.3.1

XP_036018657.1

EC 1.6.3.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001099297.1 → NP_001092767.1 dual oxidase 1 precursor

See identical proteins and their annotated locations for NP_001092767.1

Status: VALIDATED

Source sequence(s)

AL844566

Consensus CDS

CCDS38222.1

UniProtKB/TrEMBL

A2AQ92

Related

ENSMUSP00000097060.4, ENSMUST00000099461.4

Conserved Domains (4) summary

cd06186
Location:1277 → 1551

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

cd09820
Location:32 → 591

dual_peroxidase_like; Dual oxidase and related animal heme peroxidases

PLN02292
Location:1089 → 1412

PLN02292; ferric-chelate reductase

cd00051
Location:820 → 881

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

122143525..122178454

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036162764.1 → XP_036018657.1 dual oxidase 1 isoform X2

Conserved Domains (2) summary

cd09820
Location:32 → 591

dual_peroxidase_like; Dual oxidase and related animal heme peroxidases

cd00051
Location:820 → 881

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
XM_006500487.4 → XP_006500550.1 dual oxidase 1 isoform X1

See identical proteins and their annotated locations for XP_006500550.1

UniProtKB/TrEMBL

A2AQ92

Conserved Domains (4) summary

cd06186
Location:1277 → 1551

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

cd09820
Location:32 → 591

dual_peroxidase_like; Dual oxidase and related animal heme peroxidases

PLN02292
Location:1089 → 1412

PLN02292; ferric-chelate reductase

cd00051
Location:820 → 881

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
XM_030252279.2 → XP_030108139.1 dual oxidase 1 isoform X1

UniProtKB/TrEMBL

A2AQ92

Conserved Domains (4) summary

cd06186
Location:1277 → 1551

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

cd09820
Location:32 → 591

dual_peroxidase_like; Dual oxidase and related animal heme peroxidases

PLN02292
Location:1089 → 1412

PLN02292; ferric-chelate reductase

cd00051
Location:820 → 881

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...