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    Phldb2 pleckstrin homology like domain, family B, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 208177, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Phldb2provided by MGI
    Official Full Name
    pleckstrin homology like domain, family B, member 2provided by MGI
    Primary source
    MGI:MGI:2444981
    See related
    Ensembl:ENSMUSG00000033149 AllianceGenome:MGI:2444981
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LL5b; LL5beta; C820004H04Rik
    Summary
    Predicted to be involved in several processes, including negative regulation of focal adhesion assembly; regulation of cytoskeleton organization; and regulation of embryonic development. Predicted to be located in several cellular components, including cell leading edge; cytosol; and intermediate filament cytoskeleton. Predicted to be active in basal cortex. Predicted to colocalize with focal adhesion. Orthologous to human PHLDB2 (pleckstrin homology like domain family B member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in bladder adult (RPKM 19.0), limb E14.5 (RPKM 13.1) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    16 B5; 16 30.08 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (45566593..45773961, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (45746230..45953598, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40920 Neighboring gene transgelin 3 Neighboring gene STARR-seq mESC enhancer starr_40921 Neighboring gene abhydrolase domain containing 10 Neighboring gene STARR-seq mESC enhancer starr_40922 Neighboring gene predicted gene 15638 Neighboring gene phosphatidylinositol-specific phospholipase C, X domain containing 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:46006394-46006690 Neighboring gene STARR-positive B cell enhancer ABC_E4173 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:46011002-46011185 Neighboring gene predicted gene, 24754

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Phldb2 is essential for regulating hippocampal dendritic spine morphology through drebrin in an adult-type isoform-specific manner. Xie MJ, et al. Neurosci Res, 2022 Dec. PMID 36162735
    2. PIP(3)-Phldb2 is crucial for LTP regulating synaptic NMDA and AMPA receptor density and PSD95 turnover. Xie MJ, et al. Sci Rep, 2019 Mar 13. PMID 30867511, Free PMC Article
    3. CLASP2-dependent microtubule capture at the neuromuscular junction membrane requires LL5β and actin for focal delivery of acetylcholine receptor vesicles. Basu S, et al. Mol Biol Cell, 2015 Mar 1. PMID 25589673, Free PMC Article
    4. BMP2-induced chemotaxis requires PI3K p55γ/p110α-dependent phosphatidylinositol (3,4,5)-triphosphate production and LL5β recruitment at the cytocortex. Hiepen C, et al. BMC Biol, 2014 May 30. PMID 24885555, Free PMC Article
    5. LL5beta: a regulator of postsynaptic differentiation identified in a screen for synaptically enriched transcripts at the neuromuscular junction. Kishi M, et al. J Cell Biol, 2005 Apr 25. PMID 15851520, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phldb2 is essential for regulating hippocampal dendritic spine morphology through drebrin in an adult-type isoform-specific manner.
      Title: Phldb2 is essential for regulating hippocampal dendritic spine morphology through drebrin in an adult-type isoform-specific manner.
    2. PIP3-Phldb2 is crucial for LTP regulating synaptic NMDA and AMPA receptor density and PSD95 turnover.
      Title: PIP(3)-Phldb2 is crucial for LTP regulating synaptic NMDA and AMPA receptor density and PSD95 turnover.
    3. A transport system, organized by agrin through PI3 kinase, GSK3beta, CLASP2, and LL5beta, for precise delivery of acetylcholine receptor vesicles from subsynaptic nuclei to overlying synaptic membrane was identified at neuromuscular junction membrane.
      Title: CLASP2-dependent microtubule capture at the neuromuscular junction membrane requires LL5β and actin for focal delivery of acetylcholine receptor vesicles.
    4. These results provide evidence for an important contribution of the BMP2-PI3K (p55gamma/p110alpha)- PIP3-LL5beta signalling axis in mesenchymal progenitor cell chemotaxis.
      Title: BMP2-induced chemotaxis requires PI3K p55γ/p110α-dependent phosphatidylinositol (3,4,5)-triphosphate production and LL5β recruitment at the cytocortex.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in establishment of cell polarity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in establishment of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of wound healing, spreading of epidermal cells ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of basement membrane assembly involved in embryonic body morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of gastrulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in basal cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in basal cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell leading edge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    colocalizes_with focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intermediate filament cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    pleckstrin homology-like domain family B member 2
    Names
    protein LL5-beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252442.1 → NP_001239371.1  pleckstrin homology-like domain family B member 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK087133, AK165251, BB851780, BC050915, BY442240
      Consensus CDS
      CCDS57031.1
      UniProtKB/TrEMBL
      D3Z069
      Related
      ENSMUSP00000075672.6, ENSMUST00000076333.12
      Conserved Domains (4) summary
      cd14673
      Location:1191 → 1295
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:1194 → 1290
      PH; PH domain
      cl02488
      Location:597 → 786
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl19107
      Location:1085 → 1155
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    2. NM_001357078.1 → NP_001344007.1  pleckstrin homology-like domain family B member 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC164979, AC166572
      UniProtKB/TrEMBL
      D3Z069
      Conserved Domains (4) summary
      TIGR00618
      Location:523 → 1070
      sbcc; exonuclease SbcC
      COG1196
      Location:575 → 767
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14673
      Location:1095 → 1199
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam17380
      Location:987 → 1054
      DUF5401; Family of unknown function (DUF5401)

    3. NM_153412.4 → NP_700461.2  pleckstrin homology-like domain family B member 2 isoform 2

      See identical proteins and their annotated locations for NP_700461.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon and uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC164979, AC166572
      Consensus CDS
      CCDS28202.1
      UniProtKB/Swiss-Prot
      Q3TNI3, Q80Y16, Q8BKV3, Q8K1N2
      UniProtKB/TrEMBL
      D3Z069
      Related
      ENSMUSP00000046496.7, ENSMUST00000036355.13
      Conserved Domains (4) summary
      cd14673
      Location:1138 → 1242
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00169
      Location:1141 → 1237
      PH; PH domain
      cl02488
      Location:597 → 786
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl19107
      Location:1032 → 1102
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      45566593..45773961 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159845.1 → XP_036015738.1  pleckstrin homology-like domain family B member 2 isoform X20

      UniProtKB/TrEMBL
      F6QU68, Q8BZE3
      Related
      ENSMUSP00000119718.2, ENSMUST00000131003.8
      Conserved Domains (3) summary
      cd14673
      Location:507 → 611
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      TIGR02168
      Location:30 → 180
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam17380
      Location:399 → 466
      DUF5401; Family of unknown function (DUF5401)

    2. XM_006521926.4 → XP_006521989.1  pleckstrin homology-like domain family B member 2 isoform X7

      See identical proteins and their annotated locations for XP_006521989.1

      UniProtKB/TrEMBL
      D3Z069
      Related
      ENSMUSP00000123284.2, ENSMUST00000134802.8
      Conserved Domains (3) summary
      COG1196
      Location:584 → 847
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14673
      Location:1183 → 1287
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam02463
      Location:626 → 1168
      SMC_N; RecF/RecN/SMC N terminal domain

    3. XM_006521921.4 → XP_006521984.1  pleckstrin homology-like domain family B member 2 isoform X2

      UniProtKB/TrEMBL
      D3Z069
      Conserved Domains (3) summary
      COG1196
      Location:580 → 843
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14673
      Location:1240 → 1344
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00769
      Location:1132 → 1205
      ERM; Ezrin/radixin/moesin family

    4. XM_030249020.1 → XP_030104880.1  pleckstrin homology-like domain family B member 2 isoform X15

      UniProtKB/TrEMBL
      D3Z069
      Conserved Domains (3) summary
      COG1196
      Location:620 → 841
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14673
      Location:1092 → 1196
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam17380
      Location:987 → 1055
      DUF5401; Family of unknown function (DUF5401)

    5. XM_006521928.4 → XP_006521991.1  pleckstrin homology-like domain family B member 2 isoform X10

      UniProtKB/TrEMBL
      D3Z069
      Conserved Domains (3) summary
      TIGR00618
      Location:568 → 1115
      sbcc; exonuclease SbcC
      COG1196
      Location:620 → 812
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14673
      Location:1140 → 1244
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain

    6. XM_006521923.4 → XP_006521986.1  pleckstrin homology-like domain family B member 2 isoform X5

      UniProtKB/TrEMBL
      D3Z069
      Conserved Domains (3) summary
      COG1196
      Location:620 → 812
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14673
      Location:1201 → 1305
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00769
      Location:1093 → 1166
      ERM; Ezrin/radixin/moesin family

    7. XM_036159842.1 → XP_036015735.1  pleckstrin homology-like domain family B member 2 isoform X17

      UniProtKB/TrEMBL
      D3Z069
      Conserved Domains (3) summary
      COG1196
      Location:584 → 847
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14673
      Location:1088 → 1192
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      TIGR02168
      Location:712 → 1053
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    8. XM_006521929.4 → XP_006521992.1  pleckstrin homology-like domain family B member 2 isoform X11

      UniProtKB/TrEMBL
      D3Z069
      Conserved Domains (3) summary
      COG0419
      Location:628 → 1094
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:584 → 847
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14673
      Location:1135 → 1239
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain

    9. XM_006521927.4 → XP_006521990.1  pleckstrin homology-like domain family B member 2 isoform X8

      UniProtKB/TrEMBL
      D3Z069
      Conserved Domains (3) summary
      COG0419
      Location:628 → 1119
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:584 → 847
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14673
      Location:1160 → 1264
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain

    10. XM_011245859.3 → XP_011244161.1  pleckstrin homology-like domain family B member 2 isoform X3

      UniProtKB/TrEMBL
      D3Z069
      Conserved Domains (3) summary
      COG1196
      Location:584 → 847
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14673
      Location:1221 → 1325
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam15921
      Location:642 → 1172
      CCDC158; Coiled-coil domain-containing protein 158

    11. XM_006521920.4 → XP_006521983.1  pleckstrin homology-like domain family B member 2 isoform X1

      UniProtKB/TrEMBL
      D3Z069
      Conserved Domains (3) summary
      COG1196
      Location:584 → 847
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14673
      Location:1244 → 1348
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam17380
      Location:1139 → 1207
      DUF5401; Family of unknown function (DUF5401)

    12. XM_030249019.1 → XP_030104879.1  pleckstrin homology-like domain family B member 2 isoform X2

      UniProtKB/TrEMBL
      D3Z069
      Conserved Domains (3) summary
      COG1196
      Location:580 → 843
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14673
      Location:1240 → 1344
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00769
      Location:1132 → 1205
      ERM; Ezrin/radixin/moesin family

    13. XM_006521925.5 → XP_006521988.1  pleckstrin homology-like domain family B member 2 isoform X6

      See identical proteins and their annotated locations for XP_006521988.1

      UniProtKB/TrEMBL
      D3Z069
      Conserved Domains (3) summary
      COG1196
      Location:539 → 802
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14673
      Location:1199 → 1303
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam17380
      Location:1094 → 1162
      DUF5401; Family of unknown function (DUF5401)

    14. XM_006521922.5 → XP_006521985.1  pleckstrin homology-like domain family B member 2 isoform X4

      UniProtKB/TrEMBL
      D3Z069
      Conserved Domains (3) summary
      COG1196
      Location:550 → 813
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14673
      Location:1210 → 1314
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam17380
      Location:1105 → 1173
      DUF5401; Family of unknown function (DUF5401)

    15. XM_036159837.1 → XP_036015730.1  pleckstrin homology-like domain family B member 2 isoform X9

      Conserved Domains (3) summary
      COG1196
      Location:575 → 767
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14673
      Location:1156 → 1260
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam17380
      Location:1048 → 1115
      DUF5401; Family of unknown function (DUF5401)

    16. XM_006521924.5 → XP_006521987.1  pleckstrin homology-like domain family B member 2 isoform X6

      See identical proteins and their annotated locations for XP_006521987.1

      UniProtKB/TrEMBL
      D3Z069
      Conserved Domains (3) summary
      COG1196
      Location:539 → 802
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14673
      Location:1199 → 1303
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam17380
      Location:1094 → 1162
      DUF5401; Family of unknown function (DUF5401)

    17. XM_036159839.1 → XP_036015732.1  pleckstrin homology-like domain family B member 2 isoform X13

      UniProtKB/TrEMBL
      D3Z069
      Conserved Domains (3) summary
      TIGR00618
      Location:534 → 1081
      sbcc; exonuclease SbcC
      COG1196
      Location:586 → 778
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14673
      Location:1106 → 1210
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain

    18. XM_036159843.1 → XP_036015736.1  pleckstrin homology-like domain family B member 2 isoform X18

      UniProtKB/TrEMBL
      D3Z069
      Conserved Domains (3) summary
      COG1196
      Location:575 → 796
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14673
      Location:1047 → 1151
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam17380
      Location:939 → 1006
      DUF5401; Family of unknown function (DUF5401)

    19. XM_036159840.1 → XP_036015733.1  pleckstrin homology-like domain family B member 2 isoform X14

      UniProtKB/TrEMBL
      D3Z069
      Conserved Domains (4) summary
      TIGR00618
      Location:523 → 1070
      sbcc; exonuclease SbcC
      COG1196
      Location:575 → 767
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14673
      Location:1095 → 1199
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam17380
      Location:987 → 1054
      DUF5401; Family of unknown function (DUF5401)

    20. XM_036159841.1 → XP_036015734.1  pleckstrin homology-like domain family B member 2 isoform X16

      UniProtKB/TrEMBL
      D3Z069
      Conserved Domains (3) summary
      COG1196
      Location:539 → 802
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14673
      Location:1090 → 1194
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam17380
      Location:982 → 1049
      DUF5401; Family of unknown function (DUF5401)

    21. XM_036159838.1 → XP_036015731.1  pleckstrin homology-like domain family B member 2 isoform X12

      UniProtKB/TrEMBL
      D3Z069
      Conserved Domains (3) summary
      COG1196
      Location:539 → 802
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14673
      Location:1115 → 1219
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam17380
      Location:1007 → 1074
      DUF5401; Family of unknown function (DUF5401)

    22. XM_036159844.1 → XP_036015737.1  pleckstrin homology-like domain family B member 2 isoform X19

      Conserved Domains (3) summary
      cd14673
      Location:568 → 672
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      TIGR02168
      Location:30 → 180
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam17380
      Location:460 → 527
      DUF5401; Family of unknown function (DUF5401)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K1N2.2 GenPept UniProtKB/Swiss-Prot:Q8K1N2

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