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Ank2 ankyrin 2, brain [ Mus musculus (house mouse) ]

Gene ID: 109676, updated on 21-Apr-2024

Summary

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Official Symbol: Ank2provided by MGI
Official Full Name: ankyrin 2, brainprovided by MGI
Primary source: MGI:MGI:88025
See related: Ensembl:ENSMUSG00000032826 AllianceGenome:MGI:88025
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ank-2; Gm4392; 100043364
Summary: Enables several functions, including ATPase binding activity; potassium channel regulator activity; and transmembrane transporter binding activity. Involved in several processes, including positive regulation of ion transmembrane transporter activity; regulation of cardiac muscle cell action potential; and regulation of heart contraction. Acts upstream of or within several processes, including cardiac muscle contraction; regulation of cardiac muscle cell membrane potential; and regulation of cation channel activity. Located in several cellular components, including T-tubule; intercalated disc; and myofibril. Is integral component of plasma membrane. Is active in paranodal junction. Is expressed in central nervous system; eye; genitourinary system; and heart. Used to study sinoatrial node disease. Human ortholog(s) of this gene implicated in ankyrin-B-related cardiac arrhythmia; atrial fibrillation; long QT syndrome; and sick sinus syndrome. Orthologous to human ANK2 (ankyrin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cerebellum adult (RPKM 17.1), frontal lobe adult (RPKM 13.9) and 9 other tissues See more
Orthologs: human all
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Genomic context

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Location:: 3 G2; 3 56.07 cM

Exon count:: 63

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (126715256..127293996, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (126921607..127500347, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Physical and functional convergence of the autism risk genes Scn2a and Ank2 in neocortical pyramidal cell dendrites.
Title: Physical and functional convergence of the autism risk genes Scn2a and Ank2 in neocortical pyramidal cell dendrites.
Ankyrin B promotes developmental spine regulation in the mouse prefrontal cortex.
Title: Ankyrin B promotes developmental spine regulation in the mouse prefrontal cortex.
Early developmental deletion of forebrain Ank2 causes seizure-related phenotypes by reshaping the synaptic proteome.
Title: Early developmental deletion of forebrain Ank2 causes seizure-related phenotypes by reshaping the synaptic proteome.
Impact of stress on cardiac phenotypes in mice harboring an ankyrin-B disease variant.
Title: Impact of stress on cardiac phenotypes in mice harboring an ankyrin-B disease variant.
Kv7/KCNQ potassium channels in cortical hyperexcitability and juvenile seizure-related death in Ank2-mutant mice.
Title: Kv7/KCNQ potassium channels in cortical hyperexcitability and juvenile seizure-related death in Ank2-mutant mice.
Giant ankyrin-B mediates transduction of axon guidance and collateral branch pruning factor sema 3A.
Title: Giant ankyrin-B mediates transduction of axon guidance and collateral branch pruning factor sema 3A.
Coupling of the Na+/K+-ATPase to Ankyrin B controls Na+/Ca2+ exchanger activity in cardiomyocytes.
Title: Coupling of the Na+/K+-ATPase to Ankyrin B controls Na+/Ca2+ exchanger activity in cardiomyocytes.
These novel findings have important implications for understanding the role of AnkB and Cav2.1 in the regulation of neuronal function in health and disease.
Title: Ankyrin B and Ankyrin B variants differentially modulate intracellular and surface Cav2.1 levels.
findings introduce what we believe to be a new pathway for Arrhythmogenic cardiomyopathy, a role of ankyrin-B in cardiac structure and signaling, a molecular link between ankyrin-B and beta-catenin, and evidence for targeted activation of the WNT/beta-catenin pathway as a potential treatment for this disease.
Title: Ankyrin-B dysfunction predisposes to arrhythmogenic cardiomyopathy and is amenable to therapy.
Gain of axon branching due to giant ankB deficiency/mutation is a candidate cellular mechanism to explain aberrant structural connectivity and penetrant behavioral consequences in mice as well as humans bearing autism spectrum disorder-related ANK2 mutations.
Title: ANK2 autism mutation targeting giant ankyrin-B promotes axon branching and ectopic connectivity.

Submit: New GeneRIF Correction See all GeneRIFs (35)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (9) 1 citation
Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE101848 (e-PCR)
- UniSTS:243755

WIAF-2193 (e-PCR)
- UniSTS:5702

AI835472 (e-PCR)
- UniSTS:164225

28.MHAa63c4.seq (e-PCR)
- UniSTS:123811

AW491075 (e-PCR)
- UniSTS:178931

NIB1562 (e-PCR)
- UniSTS:13305

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATPase binding	IPI Inferred from Physical Interaction more info	PubMed
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables phosphorylation-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables potassium channel regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-macromolecule adaptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables spectrin binding	ISO Inferred from Sequence Orthology more info
enables structural constituent of cytoskeleton	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in SA node cell action potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in SA node cell to atrial cardiac muscle cell communication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in SA node cell to atrial cardiac muscle cell communication	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within T-tubule organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in T-tubule organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in atrial cardiac muscle cell action potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in atrial cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in atrial cardiac muscle cell to AV node cell communication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in atrial septum development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endocytosis	IEA Inferred from Electronic Annotation more info
involved_in intracellular calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of calcium ion transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cation channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of potassium ion transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of potassium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	ISO Inferred from Sequence Orthology more info
involved_in protein localization to M-band	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to T-tubule	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to T-tubule	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to cell surface	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to endoplasmic reticulum	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
involved_in protein localization to organelle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization to plasma membrane	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of AV node cell action potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of SA node cell action potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of SA node cell action potential	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of apoptotic process	RCA inferred from Reviewed Computational Analysis more info	PubMed
involved_in regulation of atrial cardiac muscle cell action potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of atrial cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium ion transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of cardiac muscle cell contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cardiac muscle cell contraction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cardiac muscle cell membrane potential	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of cardiac muscle cell membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cardiac muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cardiac muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cardiac muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of cardiac muscle contraction by calcium ion signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cardiac muscle contraction by calcium ion signaling	ISO Inferred from Sequence Orthology more info
involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	IC Inferred by Curator more info	PubMed
involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cation channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of heart rate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of heart rate	ISO Inferred from Sequence Orthology more info
involved_in regulation of heart rate by cardiac conduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of heart rate by cardiac conduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein stability	IC Inferred by Curator more info	PubMed
involved_in regulation of release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
involved_in regulation of ventricular cardiac muscle cell membrane repolarization	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in ventricular cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in A band	IDA Inferred from Direct Assay more info	PubMed
located_in M band	IDA Inferred from Direct Assay more info	PubMed
located_in M band	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in T-tubule	IBA Inferred from Biological aspect of Ancestor more info
located_in T-tubule	IDA Inferred from Direct Assay more info	PubMed
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in costamere	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info
is_active_in extrinsic component of cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in intercalated disc	IDA Inferred from Direct Assay more info	PubMed
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
is_active_in paranodal junction	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	NAS Non-traceable Author Statement more info	PubMed
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed
located_in sarcolemma	IMP Inferred from Mutant Phenotype more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ankyrin-2

Names: ankyrin-B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001034168.1 → NP_001029340.1 ankyrin-2 isoform 3

Status: VALIDATED

Source sequence(s)

AK083826, BC043123, BP753425

UniProtKB/Swiss-Prot

Q8C8R3

Conserved Domains (1) summary

cd08804
Location:494 → 577

Death_ank2; Death domain of Ankyrin-2
NM_001327938.1 → NP_001314867.1 ankyrin-2 isoform 4

Status: VALIDATED

Source sequence(s)

AC102480, AC102591, AC113952, BP753425

Conserved Domains (8) summary

smart00218
Location:961 → 1098

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

smart00248
Location:525 → 550

ANK; ankyrin repeats

COG0666
Location:302 → 500

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd00204
Location:223 → 348

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08804
Location:3543 → 3626

Death_ank2; Death domain of Ankyrin-2

pfam12796
Location:233 → 324

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:33 → 80

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:426 → 457

ANK; ANK repeat [structural motif]
NM_001327939.1 → NP_001314868.1 ankyrin-2 isoform 5

Status: VALIDATED

Source sequence(s)

AC102480, AC102591, AC105163, BP753425

Consensus CDS

CCDS84672.1

UniProtKB/TrEMBL

S4R2R5

Related

ENSMUSP00000138753.4, ENSMUST00000182078.9

Conserved Domains (8) summary

smart00218
Location:912 → 1016

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

smart00248
Location:574 → 602

ANK; ankyrin repeats

COG0666
Location:285 → 483

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd00204
Location:206 → 331

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08804
Location:3461 → 3544

Death_ank2; Death domain of Ankyrin-2

pfam12796
Location:216 → 307

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:16 → 63

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:409 → 440

ANK; ANK repeat [structural motif]
NM_178655.3 → NP_848770.2 ankyrin-2 isoform 2

See identical proteins and their annotated locations for NP_848770.2

Status: VALIDATED

Source sequence(s)

AK032060, BC043123, BC059251, BP753425

Consensus CDS

CCDS38625.1

UniProtKB/Swiss-Prot

Q8C8R3

Related

ENSMUSP00000043765.8, ENSMUST00000044443.15

Conserved Domains (2) summary

smart00218
Location:128 → 232

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08804
Location:611 → 694

Death_ank2; Death domain of Ankyrin-2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

126715256..127293996 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036162834.1 → XP_036018727.1 ankyrin-2 isoform X25

Conserved Domains (10) summary

smart00218
Location:996 → 1133

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PTZ00449
Location:2244 → 2651

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:392 → 677

PHA03095; ankyrin-like protein; Provisional

PHA03307
Location:3193 → 3520

PHA03307; transcriptional regulator ICP4; Provisional

COG5665
Location:2741 → 2972

COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]

cd08804
Location:3578 → 3661

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:418 → 449

ANK; ANK repeat [structural motif]

pfam13637
Location:749 → 801

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1354 → 1483

UPA_2; UPA domain

cl39094
Location:549 → 773

Ank_2; Ankyrin repeats (3 copies)
XM_036162844.1 → XP_036018737.1 ankyrin-2 isoform X37

Conserved Domains (11) summary

smart00218
Location:971 → 1108

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PTZ00449
Location:2219 → 2626

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:25 → 333

PHA03095; ankyrin-like protein; Provisional

PHA03307
Location:3168 → 3495

PHA03307; transcriptional regulator ICP4; Provisional

COG5665
Location:2716 → 2947

COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]

cd08804
Location:3553 → 3636

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:426 → 457

ANK; ANK repeat [structural motif]

pfam13637
Location:724 → 776

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1329 → 1458

UPA_2; UPA domain

pfam12796
Location:398 → 489

Ank_2; Ankyrin repeats (3 copies)

cl39094
Location:473 → 748

Ank_2; Ankyrin repeats (3 copies)
XM_006500891.3 → XP_006500954.1 ankyrin-2 isoform X28

Conserved Domains (10) summary

smart00218
Location:986 → 1123

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PTZ00449
Location:2234 → 2641

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:400 → 685

PHA03095; ankyrin-like protein; Provisional

PHA03307
Location:3183 → 3510

PHA03307; transcriptional regulator ICP4; Provisional

COG5665
Location:2731 → 2962

COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]

cd08804
Location:3568 → 3651

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:426 → 457

ANK; ANK repeat [structural motif]

pfam13637
Location:757 → 809

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1344 → 1473

UPA_2; UPA domain

cl39094
Location:557 → 781

Ank_2; Ankyrin repeats (3 copies)
XM_036162832.1 → XP_036018725.1 ankyrin-2 isoform X21

Conserved Domains (10) summary

smart00218
Location:1004 → 1141

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PTZ00449
Location:2252 → 2659

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:400 → 685

PHA03095; ankyrin-like protein; Provisional

PHA03307
Location:3201 → 3528

PHA03307; transcriptional regulator ICP4; Provisional

COG5665
Location:2749 → 2980

COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]

cd08804
Location:3586 → 3669

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:426 → 457

ANK; ANK repeat [structural motif]

pfam13637
Location:757 → 809

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1362 → 1491

UPA_2; UPA domain

cl39094
Location:557 → 781

Ank_2; Ankyrin repeats (3 copies)
XM_036162820.1 → XP_036018713.1 ankyrin-2 isoform X9

Conserved Domains (10) summary

smart00218
Location:1037 → 1174

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PTZ00449
Location:2285 → 2692

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:433 → 718

PHA03095; ankyrin-like protein; Provisional

PHA03307
Location:3234 → 3561

PHA03307; transcriptional regulator ICP4; Provisional

COG5665
Location:2782 → 3013

COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]

cd08804
Location:3619 → 3702

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:459 → 490

ANK; ANK repeat [structural motif]

pfam13637
Location:790 → 842

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1395 → 1524

UPA_2; UPA domain

cl39094
Location:590 → 814

Ank_2; Ankyrin repeats (3 copies)
XM_036162849.1 → XP_036018742.1 ankyrin-2 isoform X44

Conserved Domains (11) summary

smart00218
Location:954 → 1091

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PTZ00449
Location:2202 → 2609

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:8 → 316

PHA03095; ankyrin-like protein; Provisional

PHA03307
Location:3151 → 3478

PHA03307; transcriptional regulator ICP4; Provisional

COG5665
Location:2699 → 2930

COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]

cd08804
Location:3536 → 3619

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:409 → 440

ANK; ANK repeat [structural motif]

pfam13637
Location:707 → 759

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1312 → 1441

UPA_2; UPA domain

pfam12796
Location:381 → 472

Ank_2; Ankyrin repeats (3 copies)

cl39094
Location:456 → 731

Ank_2; Ankyrin repeats (3 copies)
XM_036162846.1 → XP_036018739.1 ankyrin-2 isoform X41

Conserved Domains (10) summary

smart00218
Location:965 → 1102

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PTZ00449
Location:2213 → 2620

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:383 → 668

PHA03095; ankyrin-like protein; Provisional

PHA03307
Location:3162 → 3489

PHA03307; transcriptional regulator ICP4; Provisional

COG5665
Location:2710 → 2941

COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]

cd08804
Location:3547 → 3630

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:409 → 440

ANK; ANK repeat [structural motif]

pfam13637
Location:740 → 792

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1323 → 1452

UPA_2; UPA domain

cl39094
Location:540 → 764

Ank_2; Ankyrin repeats (3 copies)
XM_006500893.4 → XP_006500956.1 ankyrin-2 isoform X39

Conserved Domains (10) summary

smart00218
Location:969 → 1106

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PTZ00449
Location:2217 → 2624

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:383 → 668

PHA03095; ankyrin-like protein; Provisional

PHA03307
Location:3166 → 3493

PHA03307; transcriptional regulator ICP4; Provisional

COG5665
Location:2714 → 2945

COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]

cd08804
Location:3551 → 3634

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:409 → 440

ANK; ANK repeat [structural motif]

pfam13637
Location:740 → 792

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1327 → 1456

UPA_2; UPA domain

cl39094
Location:540 → 764

Ank_2; Ankyrin repeats (3 copies)
XM_036162835.1 → XP_036018728.1 ankyrin-2 isoform X26

Conserved Domains (10) summary

smart00218
Location:987 → 1124

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PTZ00449
Location:2235 → 2642

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:383 → 668

PHA03095; ankyrin-like protein; Provisional

PHA03307
Location:3184 → 3511

PHA03307; transcriptional regulator ICP4; Provisional

COG5665
Location:2732 → 2963

COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]

cd08804
Location:3569 → 3652

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:409 → 440

ANK; ANK repeat [structural motif]

pfam13637
Location:740 → 792

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1345 → 1474

UPA_2; UPA domain

cl39094
Location:540 → 764

Ank_2; Ankyrin repeats (3 copies)
XM_036162850.1 → XP_036018743.1 ankyrin-2 isoform X45

Related

ENSMUSP00000138620.4, ENSMUST00000182064.9

Conserved Domains (10) summary

smart00218
Location:940 → 1077

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PTZ00449
Location:2188 → 2595

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:378 → 663

PHA03095; ankyrin-like protein; Provisional

PHA03307
Location:3137 → 3464

PHA03307; transcriptional regulator ICP4; Provisional

COG5665
Location:2685 → 2916

COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]

cd08804
Location:3522 → 3605

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:404 → 435

ANK; ANK repeat [structural motif]

pfam13637
Location:735 → 787

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1298 → 1427

UPA_2; UPA domain

cl39094
Location:535 → 759

Ank_2; Ankyrin repeats (3 copies)
XM_036162840.1 → XP_036018733.1 ankyrin-2 isoform X33

Conserved Domains (10) summary

smart00218
Location:979 → 1116

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PTZ00449
Location:2227 → 2634

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:375 → 660

PHA03095; ankyrin-like protein; Provisional

PHA03307
Location:3176 → 3503

PHA03307; transcriptional regulator ICP4; Provisional

COG5665
Location:2724 → 2955

COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]

cd08804
Location:3561 → 3644

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:401 → 432

ANK; ANK repeat [structural motif]

pfam13637
Location:732 → 784

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1337 → 1466

UPA_2; UPA domain

cl39094
Location:532 → 756

Ank_2; Ankyrin repeats (3 copies)
XM_036162829.1 → XP_036018722.1 ankyrin-2 isoform X18

Conserved Domains (10) summary

smart00218
Location:1012 → 1149

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PTZ00449
Location:2260 → 2667

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:408 → 693

PHA03095; ankyrin-like protein; Provisional

PHA03307
Location:3209 → 3536

PHA03307; transcriptional regulator ICP4; Provisional

COG5665
Location:2757 → 2988

COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]

cd08804
Location:3594 → 3677

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:434 → 465

ANK; ANK repeat [structural motif]

pfam13637
Location:765 → 817

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1370 → 1499

UPA_2; UPA domain

cl39094
Location:565 → 789

Ank_2; Ankyrin repeats (3 copies)
XM_036162836.1 → XP_036018729.1 ankyrin-2 isoform X27

Conserved Domains (10) summary

smart00218
Location:987 → 1124

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PTZ00449
Location:2235 → 2642

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:392 → 668

PHA03095; ankyrin-like protein; Provisional

PHA03307
Location:3184 → 3511

PHA03307; transcriptional regulator ICP4; Provisional

COG5665
Location:2732 → 2963

COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]

cd08804
Location:3569 → 3652

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:409 → 440

ANK; ANK repeat [structural motif]

pfam13637
Location:740 → 792

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1345 → 1474

UPA_2; UPA domain

cl39094
Location:540 → 764

Ank_2; Ankyrin repeats (3 copies)
XM_036162837.1 → XP_036018730.1 ankyrin-2 isoform X29

Conserved Domains (11) summary

smart00218
Location:987 → 1124

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PTZ00449
Location:2235 → 2642

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:39 → 349

PHA03095; ankyrin-like protein; Provisional

PHA03307
Location:3184 → 3511

PHA03307; transcriptional regulator ICP4; Provisional

COG5665
Location:2732 → 2963

COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]

cd08804
Location:3569 → 3652

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:442 → 473

ANK; ANK repeat [structural motif]

pfam13637
Location:740 → 792

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1345 → 1474

UPA_2; UPA domain

pfam12796
Location:414 → 505

Ank_2; Ankyrin repeats (3 copies)

cl39094
Location:489 → 764

Ank_2; Ankyrin repeats (3 copies)
XM_036162825.1 → XP_036018718.1 ankyrin-2 isoform X14

Conserved Domains (10) summary

smart00218
Location:1020 → 1157

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PTZ00449
Location:2268 → 2675

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:416 → 701

PHA03095; ankyrin-like protein; Provisional

PHA03307
Location:3217 → 3544

PHA03307; transcriptional regulator ICP4; Provisional

COG5665
Location:2765 → 2996

COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]

cd08804
Location:3602 → 3685

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:442 → 473

ANK; ANK repeat [structural motif]

pfam13637
Location:773 → 825

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1378 → 1507

UPA_2; UPA domain

cl39094
Location:573 → 797

Ank_2; Ankyrin repeats (3 copies)
XM_036162843.1 → XP_036018736.1 ankyrin-2 isoform X36

Conserved Domains (10) summary

smart00218
Location:974 → 1111

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PTZ00449
Location:2222 → 2629

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:370 → 655

PHA03095; ankyrin-like protein; Provisional

PHA03307
Location:3171 → 3498

PHA03307; transcriptional regulator ICP4; Provisional

COG5665
Location:2719 → 2950

COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]

cd08804
Location:3556 → 3639

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:396 → 427

ANK; ANK repeat [structural motif]

pfam13637
Location:727 → 779

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1332 → 1461

UPA_2; UPA domain

cl39094
Location:527 → 751

Ank_2; Ankyrin repeats (3 copies)
XM_036162839.1 → XP_036018732.1 ankyrin-2 isoform X32

Conserved Domains (10) summary

smart00218
Location:982 → 1119

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PTZ00449
Location:2230 → 2637

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:378 → 663

PHA03095; ankyrin-like protein; Provisional

PHA03307
Location:3179 → 3506

PHA03307; transcriptional regulator ICP4; Provisional

COG5665
Location:2727 → 2958

COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]

cd08804
Location:3564 → 3647

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:404 → 435

ANK; ANK repeat [structural motif]

pfam13637
Location:735 → 787

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1340 → 1469

UPA_2; UPA domain

cl39094
Location:535 → 759

Ank_2; Ankyrin repeats (3 copies)
XM_036162852.1 → XP_036018745.1 ankyrin-2 isoform X47

Conserved Domains (10) summary

smart00218
Location:873 → 1010

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PTZ00449
Location:2121 → 2528

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:269 → 554

PHA03095; ankyrin-like protein; Provisional

PHA03307
Location:3070 → 3397

PHA03307; transcriptional regulator ICP4; Provisional

COG5665
Location:2618 → 2849

COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]

cd08804
Location:3455 → 3538

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:295 → 326

ANK; ANK repeat [structural motif]

pfam13637
Location:626 → 678

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1231 → 1360

UPA_2; UPA domain

cl39094
Location:426 → 650

Ank_2; Ankyrin repeats (3 copies)
XM_036162847.1 → XP_036018740.1 ankyrin-2 isoform X42

Conserved Domains (10) summary

smart00218
Location:961 → 1098

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PTZ00449
Location:2209 → 2616

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:375 → 660

PHA03095; ankyrin-like protein; Provisional

PHA03307
Location:3158 → 3485

PHA03307; transcriptional regulator ICP4; Provisional

COG5665
Location:2706 → 2937

COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]

cd08804
Location:3543 → 3626

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:401 → 432

ANK; ANK repeat [structural motif]

pfam13637
Location:732 → 784

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1319 → 1448

UPA_2; UPA domain

cl39094
Location:532 → 756

Ank_2; Ankyrin repeats (3 copies)
XM_036162851.1 → XP_036018744.1 ankyrin-2 isoform X46

Conserved Domains (11) summary

smart00218
Location:936 → 1073

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PHA02876
Location:260 → 600

PHA02876; ankyrin repeat protein; Provisional

PTZ00449
Location:2184 → 2591

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:39 → 349

PHA03095; ankyrin-like protein; Provisional

PHA03307
Location:3133 → 3460

PHA03307; transcriptional regulator ICP4; Provisional

COG5665
Location:2681 → 2912

COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]

cd08804
Location:3518 → 3601

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:640 → 671

ANK; ANK repeat [structural motif]

pfam13637
Location:707 → 759

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1294 → 1423

UPA_2; UPA domain

cl39094
Location:507 → 731

Ank_2; Ankyrin repeats (3 copies)
XM_030252368.2 → XP_030108228.1 ankyrin-2 isoform X40

Conserved Domains (11) summary

smart00218
Location:969 → 1106

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PTZ00449
Location:2217 → 2624

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:39 → 349

PHA03095; ankyrin-like protein; Provisional

PHA03307
Location:3166 → 3493

PHA03307; transcriptional regulator ICP4; Provisional

COG5665
Location:2714 → 2945

COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]

cd08804
Location:3551 → 3634

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:442 → 473

ANK; ANK repeat [structural motif]

pfam12796
Location:414 → 505

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:740 → 792

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1327 → 1456

UPA_2; UPA domain

cl39094
Location:489 → 764

Ank_2; Ankyrin repeats (3 copies)
XM_030252365.2 → XP_030108225.1 ankyrin-2 isoform X30

Conserved Domains (10) summary

smart00218
Location:985 → 1122

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PTZ00449
Location:2233 → 2640

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:416 → 701

PHA03095; ankyrin-like protein; Provisional

PHA03307
Location:3182 → 3509

PHA03307; transcriptional regulator ICP4; Provisional

COG5665
Location:2730 → 2961

COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]

cd08804
Location:3567 → 3650

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:442 → 473

ANK; ANK repeat [structural motif]

pfam13637
Location:773 → 825

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1343 → 1472

UPA_2; UPA domain

cl39094
Location:573 → 797

Ank_2; Ankyrin repeats (3 copies)
XM_006500886.4 → XP_006500949.1 ankyrin-2 isoform X23

Conserved Domains (10) summary

smart00218
Location:1002 → 1139

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PTZ00449
Location:2250 → 2657

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:416 → 701

PHA03095; ankyrin-like protein; Provisional

PHA03307
Location:3199 → 3526

PHA03307; transcriptional regulator ICP4; Provisional

COG5665
Location:2747 → 2978

COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]

cd08804
Location:3584 → 3667

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:442 → 473

ANK; ANK repeat [structural motif]

pfam13637
Location:773 → 825

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1360 → 1489

UPA_2; UPA domain

cl39094
Location:573 → 797

Ank_2; Ankyrin repeats (3 copies)
XM_036162831.1 → XP_036018724.1 ankyrin-2 isoform X20

Conserved Domains (10) summary

smart00218
Location:1066 → 1203

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PTZ00449
Location:2314 → 2721

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:462 → 747

PHA03095; ankyrin-like protein; Provisional

PHA03307
Location:3263 → 3590

PHA03307; transcriptional regulator ICP4; Provisional

COG5665
Location:2811 → 3042

COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]

cd08804
Location:3648 → 3731

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:488 → 519

ANK; ANK repeat [structural motif]

pfam13637
Location:819 → 871

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1424 → 1553

UPA_2; UPA domain

cl39094
Location:619 → 843

Ank_2; Ankyrin repeats (3 copies)
XM_036162824.1 → XP_036018717.1 ankyrin-2 isoform X13

Conserved Domains (10) summary

smart00218
Location:1054 → 1158

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PTZ00449
Location:2269 → 2676

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:462 → 747

PHA03095; ankyrin-like protein; Provisional

PHA03307
Location:3218 → 3545

PHA03307; transcriptional regulator ICP4; Provisional

COG5665
Location:2766 → 2997

COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]

cd08804
Location:3603 → 3686

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:488 → 519

ANK; ANK repeat [structural motif]

pfam13637
Location:819 → 871

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1379 → 1508

UPA_2; UPA domain

cl39094
Location:619 → 843

Ank_2; Ankyrin repeats (3 copies)
XM_036162827.1 → XP_036018720.1 ankyrin-2 isoform X16

Conserved Domains (10) summary

smart00218
Location:1046 → 1150

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PTZ00449
Location:2261 → 2668

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:462 → 747

PHA03095; ankyrin-like protein; Provisional

PHA03307
Location:3210 → 3537

PHA03307; transcriptional regulator ICP4; Provisional

COG5665
Location:2758 → 2989

COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]

cd08804
Location:3595 → 3678

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:488 → 519

ANK; ANK repeat [structural motif]

pfam13637
Location:819 → 871

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1371 → 1500

UPA_2; UPA domain

cl39094
Location:619 → 843

Ank_2; Ankyrin repeats (3 copies)
XM_036162853.1 → XP_036018746.1 ankyrin-2 isoform X48

Conserved Domains (7) summary

smart00218
Location:1066 → 1203

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PHA03095
Location:462 → 747

PHA03095; ankyrin-like protein; Provisional

cd08804
Location:1582 → 1665

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:488 → 519

ANK; ANK repeat [structural motif]

pfam13637
Location:819 → 871

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1424 → 1553

UPA_2; UPA domain

cl39094
Location:619 → 843

Ank_2; Ankyrin repeats (3 copies)
XM_011239990.1 → XP_011238292.1 ankyrin-2 isoform X8

Conserved Domains (10) summary

smart00218
Location:846 → 983

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PTZ00449
Location:2094 → 2501

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:269 → 554

PHA03095; ankyrin-like protein; Provisional

PHA03307
Location:3043 → 3370

PHA03307; transcriptional regulator ICP4; Provisional

COG5665
Location:2591 → 2822

COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]

cd08804
Location:3428 → 3511

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:295 → 326

ANK; ANK repeat [structural motif]

pfam13637
Location:626 → 678

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1204 → 1333

UPA_2; UPA domain

cl39094
Location:426 → 650

Ank_2; Ankyrin repeats (3 copies)
XM_011239986.1 → XP_011238288.1 ankyrin-2 isoform X7

Conserved Domains (10) summary

smart00218
Location:851 → 988

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PTZ00449
Location:2099 → 2506

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:269 → 554

PHA03095; ankyrin-like protein; Provisional

PHA03307
Location:3048 → 3375

PHA03307; transcriptional regulator ICP4; Provisional

COG5665
Location:2596 → 2827

COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]

cd08804
Location:3433 → 3516

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:295 → 326

ANK; ANK repeat [structural motif]

pfam13637
Location:626 → 678

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1209 → 1338

UPA_2; UPA domain

cl39094
Location:426 → 650

Ank_2; Ankyrin repeats (3 copies)
XM_036162817.1 → XP_036018710.1 ankyrin-2 isoform X4

Conserved Domains (10) summary

smart00218
Location:864 → 1001

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PTZ00449
Location:2112 → 2519

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:269 → 554

PHA03095; ankyrin-like protein; Provisional

PHA03307
Location:3061 → 3388

PHA03307; transcriptional regulator ICP4; Provisional

COG5665
Location:2609 → 2840

COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]

cd08804
Location:3446 → 3529

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:295 → 326

ANK; ANK repeat [structural motif]

pfam13637
Location:626 → 678

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1222 → 1351

UPA_2; UPA domain

cl39094
Location:426 → 650

Ank_2; Ankyrin repeats (3 copies)
XM_036162818.1 → XP_036018711.1 ankyrin-2 isoform X5

Conserved Domains (10) summary

smart00218
Location:861 → 998

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PTZ00449
Location:2109 → 2516

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:269 → 554

PHA03095; ankyrin-like protein; Provisional

PHA03307
Location:3058 → 3385

PHA03307; transcriptional regulator ICP4; Provisional

COG5665
Location:2606 → 2837

COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]

cd08804
Location:3443 → 3526

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:295 → 326

ANK; ANK repeat [structural motif]

pfam13637
Location:626 → 678

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1219 → 1348

UPA_2; UPA domain

cl39094
Location:426 → 650

Ank_2; Ankyrin repeats (3 copies)
XM_036162814.1 → XP_036018707.1 ankyrin-2 isoform X1

Conserved Domains (10) summary

smart00218
Location:869 → 1006

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PTZ00449
Location:2117 → 2524

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:269 → 554

PHA03095; ankyrin-like protein; Provisional

PHA03307
Location:3066 → 3393

PHA03307; transcriptional regulator ICP4; Provisional

COG5665
Location:2614 → 2845

COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]

cd08804
Location:3451 → 3534

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:295 → 326

ANK; ANK repeat [structural motif]

pfam13637
Location:626 → 678

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1227 → 1356

UPA_2; UPA domain

cl39094
Location:426 → 650

Ank_2; Ankyrin repeats (3 copies)
XM_036162815.1 → XP_036018708.1 ankyrin-2 isoform X2

Conserved Domains (10) summary

smart00218
Location:868 → 1005

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PTZ00449
Location:2116 → 2523

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:269 → 554

PHA03095; ankyrin-like protein; Provisional

PHA03307
Location:3065 → 3392

PHA03307; transcriptional regulator ICP4; Provisional

COG5665
Location:2613 → 2844

COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]

cd08804
Location:3450 → 3533

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:295 → 326

ANK; ANK repeat [structural motif]

pfam13637
Location:626 → 678

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1226 → 1355

UPA_2; UPA domain

cl39094
Location:426 → 650

Ank_2; Ankyrin repeats (3 copies)
XM_036162819.1 → XP_036018712.1 ankyrin-2 isoform X6

Conserved Domains (10) summary

smart00218
Location:853 → 990

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PTZ00449
Location:2101 → 2508

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:269 → 554

PHA03095; ankyrin-like protein; Provisional

PHA03307
Location:3050 → 3377

PHA03307; transcriptional regulator ICP4; Provisional

COG5665
Location:2598 → 2829

COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]

cd08804
Location:3435 → 3518

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:295 → 326

ANK; ANK repeat [structural motif]

pfam13637
Location:626 → 678

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1211 → 1340

UPA_2; UPA domain

cl39094
Location:426 → 650

Ank_2; Ankyrin repeats (3 copies)
XM_036162816.1 → XP_036018709.1 ankyrin-2 isoform X3

Conserved Domains (10) summary

smart00218
Location:865 → 1002

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PTZ00449
Location:2113 → 2520

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:269 → 554

PHA03095; ankyrin-like protein; Provisional

PHA03307
Location:3062 → 3389

PHA03307; transcriptional regulator ICP4; Provisional

COG5665
Location:2610 → 2841

COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]

cd08804
Location:3447 → 3530

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:295 → 326

ANK; ANK repeat [structural motif]

pfam13637
Location:626 → 678

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1223 → 1352

UPA_2; UPA domain

cl39094
Location:426 → 650

Ank_2; Ankyrin repeats (3 copies)
XM_036162821.1 → XP_036018714.1 ankyrin-2 isoform X10

Conserved Domains (10) summary

smart00218
Location:873 → 977

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PTZ00449
Location:2088 → 2495

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:269 → 554

PHA03095; ankyrin-like protein; Provisional

PHA03307
Location:3037 → 3364

PHA03307; transcriptional regulator ICP4; Provisional

COG5665
Location:2585 → 2816

COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]

cd08804
Location:3422 → 3505

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:295 → 326

ANK; ANK repeat [structural motif]

pfam13637
Location:626 → 678

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1198 → 1327

UPA_2; UPA domain

cl39094
Location:426 → 650

Ank_2; Ankyrin repeats (3 copies)
XM_036162845.1 → XP_036018738.1 ankyrin-2 isoform X38

Conserved Domains (11) summary

smart00218
Location:967 → 1104

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PTZ00449
Location:2215 → 2622

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:27 → 329

PHA03095; ankyrin-like protein; Provisional

PHA03307
Location:3164 → 3491

PHA03307; transcriptional regulator ICP4; Provisional

COG5665
Location:2712 → 2943

COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]

cd08804
Location:3549 → 3632

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:422 → 453

ANK; ANK repeat [structural motif]

pfam13637
Location:720 → 772

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1325 → 1454

UPA_2; UPA domain

pfam12796
Location:394 → 485

Ank_2; Ankyrin repeats (3 copies)

cl39094
Location:469 → 744

Ank_2; Ankyrin repeats (3 copies)
XM_036162833.1 → XP_036018726.1 ankyrin-2 isoform X22

Conserved Domains (10) summary

smart00218
Location:1000 → 1137

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PTZ00449
Location:2248 → 2655

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:396 → 681

PHA03095; ankyrin-like protein; Provisional

PHA03307
Location:3197 → 3524

PHA03307; transcriptional regulator ICP4; Provisional

COG5665
Location:2745 → 2976

COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]

cd08804
Location:3582 → 3665

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:422 → 453

ANK; ANK repeat [structural motif]

pfam13637
Location:753 → 805

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1358 → 1487

UPA_2; UPA domain

cl39094
Location:553 → 777

Ank_2; Ankyrin repeats (3 copies)
XM_036162841.1 → XP_036018734.1 ankyrin-2 isoform X34

UniProtKB/TrEMBL

S4R2F3

Conserved Domains (10) summary

smart00218
Location:975 → 1112

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PTZ00449
Location:2223 → 2630

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:380 → 656

PHA03095; ankyrin-like protein; Provisional

PHA03307
Location:3172 → 3499

PHA03307; transcriptional regulator ICP4; Provisional

COG5665
Location:2720 → 2951

COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]

cd08804
Location:3557 → 3640

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:397 → 428

ANK; ANK repeat [structural motif]

pfam13637
Location:728 → 780

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1333 → 1462

UPA_2; UPA domain

cl39094
Location:528 → 752

Ank_2; Ankyrin repeats (3 copies)
XM_036162848.1 → XP_036018741.1 ankyrin-2 isoform X43

UniProtKB/TrEMBL

S4R2F3

Conserved Domains (11) summary

smart00218
Location:957 → 1094

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PTZ00449
Location:2205 → 2612

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:27 → 337

PHA03095; ankyrin-like protein; Provisional

PHA03307
Location:3154 → 3481

PHA03307; transcriptional regulator ICP4; Provisional

COG5665
Location:2702 → 2933

COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]

cd08804
Location:3539 → 3622

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:430 → 461

ANK; ANK repeat [structural motif]

pfam13637
Location:728 → 780

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1315 → 1444

UPA_2; UPA domain

pfam12796
Location:402 → 493

Ank_2; Ankyrin repeats (3 copies)

cl39094
Location:477 → 752

Ank_2; Ankyrin repeats (3 copies)
XM_036162842.1 → XP_036018735.1 ankyrin-2 isoform X35

UniProtKB/TrEMBL

S4R2F3

Conserved Domains (11) summary

smart00218
Location:975 → 1112

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PTZ00449
Location:2223 → 2630

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:27 → 337

PHA03095; ankyrin-like protein; Provisional

PHA03307
Location:3172 → 3499

PHA03307; transcriptional regulator ICP4; Provisional

COG5665
Location:2720 → 2951

COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]

cd08804
Location:3557 → 3640

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:430 → 461

ANK; ANK repeat [structural motif]

pfam13637
Location:728 → 780

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1333 → 1462

UPA_2; UPA domain

pfam12796
Location:402 → 493

Ank_2; Ankyrin repeats (3 copies)

cl39094
Location:477 → 752

Ank_2; Ankyrin repeats (3 copies)
XM_036162830.1 → XP_036018723.1 ankyrin-2 isoform X19

UniProtKB/TrEMBL

S4R2F3

Conserved Domains (10) summary

smart00218
Location:1008 → 1145

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PTZ00449
Location:2256 → 2663

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:404 → 689

PHA03095; ankyrin-like protein; Provisional

PHA03307
Location:3205 → 3532

PHA03307; transcriptional regulator ICP4; Provisional

COG5665
Location:2753 → 2984

COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]

cd08804
Location:3590 → 3673

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:430 → 461

ANK; ANK repeat [structural motif]

pfam13637
Location:761 → 813

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1366 → 1495

UPA_2; UPA domain

cl39094
Location:561 → 785

Ank_2; Ankyrin repeats (3 copies)
XM_036162838.1 → XP_036018731.1 ankyrin-2 isoform X31

Conserved Domains (10) summary

smart00218
Location:982 → 1119

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PTZ00449
Location:2230 → 2637

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:396 → 681

PHA03095; ankyrin-like protein; Provisional

PHA03307
Location:3179 → 3506

PHA03307; transcriptional regulator ICP4; Provisional

COG5665
Location:2727 → 2958

COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]

cd08804
Location:3564 → 3647

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:422 → 453

ANK; ANK repeat [structural motif]

pfam13637
Location:753 → 805

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1340 → 1469

UPA_2; UPA domain

cl39094
Location:553 → 777

Ank_2; Ankyrin repeats (3 copies)
XM_017319427.2 → XP_017174916.1 ankyrin-2 isoform X24

Conserved Domains (10) summary

smart00218
Location:997 → 1134

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PTZ00449
Location:2245 → 2652

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:411 → 696

PHA03095; ankyrin-like protein; Provisional

PHA03307
Location:3194 → 3521

PHA03307; transcriptional regulator ICP4; Provisional

COG5665
Location:2742 → 2973

COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]

cd08804
Location:3579 → 3662

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:437 → 468

ANK; ANK repeat [structural motif]

pfam13637
Location:768 → 820

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1355 → 1484

UPA_2; UPA domain

cl39094
Location:568 → 792

Ank_2; Ankyrin repeats (3 copies)
XM_036162823.1 → XP_036018716.1 ankyrin-2 isoform X12

Conserved Domains (10) summary

smart00218
Location:1023 → 1160

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PTZ00449
Location:2271 → 2678

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:419 → 704

PHA03095; ankyrin-like protein; Provisional

PHA03307
Location:3220 → 3547

PHA03307; transcriptional regulator ICP4; Provisional

COG5665
Location:2768 → 2999

COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]

cd08804
Location:3605 → 3688

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:445 → 476

ANK; ANK repeat [structural motif]

pfam13637
Location:776 → 828

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1381 → 1510

UPA_2; UPA domain

cl39094
Location:576 → 800

Ank_2; Ankyrin repeats (3 copies)
XM_036162826.1 → XP_036018719.1 ankyrin-2 isoform X15

Conserved Domains (10) summary

smart00218
Location:1015 → 1152

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PTZ00449
Location:2263 → 2670

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:411 → 696

PHA03095; ankyrin-like protein; Provisional

PHA03307
Location:3212 → 3539

PHA03307; transcriptional regulator ICP4; Provisional

COG5665
Location:2760 → 2991

COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]

cd08804
Location:3597 → 3680

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:437 → 468

ANK; ANK repeat [structural motif]

pfam13637
Location:768 → 820

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1373 → 1502

UPA_2; UPA domain

cl39094
Location:568 → 792

Ank_2; Ankyrin repeats (3 copies)
XM_036162855.1 → XP_036018748.1 ankyrin-2 isoform X50

Conserved Domains (10) summary

smart00218
Location:1005 → 1142

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PTZ00449
Location:2253 → 2660

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:413 → 698

PHA03095; ankyrin-like protein; Provisional

PHA03307
Location:3202 → 3529

PHA03307; transcriptional regulator ICP4; Provisional

COG5665
Location:2750 → 2981

COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]

cd08804
Location:3587 → 3670

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:439 → 470

ANK; ANK repeat [structural motif]

pfam13637
Location:770 → 822

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1363 → 1492

UPA_2; UPA domain

cl39094
Location:570 → 794

Ank_2; Ankyrin repeats (3 copies)
XM_036162854.1 → XP_036018747.1 ankyrin-2 isoform X49

Conserved Domains (10) summary

smart00218
Location:1013 → 1150

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PTZ00449
Location:2261 → 2668

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:421 → 706

PHA03095; ankyrin-like protein; Provisional

PHA03307
Location:3210 → 3537

PHA03307; transcriptional regulator ICP4; Provisional

COG5665
Location:2758 → 2989

COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]

cd08804
Location:3595 → 3678

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:447 → 478

ANK; ANK repeat [structural motif]

pfam13637
Location:778 → 830

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1371 → 1500

UPA_2; UPA domain

cl39094
Location:578 → 802

Ank_2; Ankyrin repeats (3 copies)
XM_036162822.1 → XP_036018715.1 ankyrin-2 isoform X11

Conserved Domains (10) summary

smart00218
Location:1025 → 1162

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PTZ00449
Location:2273 → 2680

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:421 → 706

PHA03095; ankyrin-like protein; Provisional

PHA03307
Location:3222 → 3549

PHA03307; transcriptional regulator ICP4; Provisional

COG5665
Location:2770 → 3001

COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]

cd08804
Location:3607 → 3690

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:447 → 478

ANK; ANK repeat [structural motif]

pfam13637
Location:778 → 830

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1383 → 1512

UPA_2; UPA domain

cl39094
Location:578 → 802

Ank_2; Ankyrin repeats (3 copies)
XM_036162828.1 → XP_036018721.1 ankyrin-2 isoform X17

Conserved Domains (10) summary

smart00218
Location:1013 → 1150

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

PTZ00449
Location:2261 → 2668

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:421 → 706

PHA03095; ankyrin-like protein; Provisional

PHA03307
Location:3210 → 3537

PHA03307; transcriptional regulator ICP4; Provisional

COG5665
Location:2758 → 2989

COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]

cd08804
Location:3595 → 3678

Death_ank2; Death domain of Ankyrin-2

sd00045
Location:447 → 478

ANK; ANK repeat [structural motif]

pfam13637
Location:778 → 830

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1371 → 1500

UPA_2; UPA domain

cl39094
Location:578 → 802

Ank_2; Ankyrin repeats (3 copies)