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    Nme6 NME/NM23 nucleoside diphosphate kinase 6 [ Mus musculus (house mouse) ]

    Gene ID: 54369, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Nme6provided by MGI
    Official Full Name
    NME/NM23 nucleoside diphosphate kinase 6provided by MGI
    Primary source
    MGI:MGI:1861676
    See related
    Ensembl:ENSMUSG00000032478 AllianceGenome:MGI:1861676
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    nm23-M6
    Summary
    Predicted to enable nucleoside diphosphate kinase activity. Predicted to be involved in negative regulation of cell growth and negative regulation of mitotic nuclear division. Predicted to act upstream of or within nucleotide metabolic process and phosphorylation. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; nervous system; and sensory organ. Orthologous to human NME6 (NME/NM23 nucleoside diphosphate kinase 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 39.4), placenta adult (RPKM 12.5) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 F2; 9 59.79 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (109661830..109672042)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (109832722..109842974)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51691 Neighboring gene serine peptidase inhibitor, Kazal type 8 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene cathelicidin antimicrobial peptide Neighboring gene STARR-positive B cell enhancer ABC_E9775 Neighboring gene predicted gene, 39427

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A shRNA functional screen reveals Nme6 and Nme7 are crucial for embryonic stem cell renewal. Wang CH, et al. Stem Cells, 2012 Oct. PMID 22899353
    2. NME6: a new member of the nm23/nucleoside diphosphate kinase gene family located on human chromosome 3p21.3. Mehus JG, et al. Hum Genet, 1999 Jun. PMID 10453732
    3. DDX1 vesicles control calcium-dependent mitochondrial activity in mouse embryos. Wang Y, et al. Nat Commun, 2022 Jul 1. PMID 35778392, Free PMC Article
    4. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812
    5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nme6 or Nme7 can regulate several critical processes in embryonic stem cell renewal.
      Title: A shRNA functional screen reveals Nme6 and Nme7 are crucial for embryonic stem cell renewal.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleoside diphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleoside diphosphate kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in CTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in UTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell growth IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of mitotic nuclear division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of mitotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within nucleotide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nucleoside diphosphate kinase 6
    Names
    NDK 6
    NDP kinase 6
    expressed in non-metastatic cells 6, protein (nucleoside diphosphate kinase)
    nm23/nucleoside diphosphate kinase 6
    non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase)
    nucleoside diphosphate kinase type 6
    NP_001396623.1
    NP_001396624.1
    NP_001396625.1
    NP_001396627.1
    NP_001396628.1
    NP_001396629.1
    NP_001396630.1
    NP_001396631.1
    NP_001396632.1
    NP_061227.1
    XP_006512262.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001409694.1 → NP_001396623.1  nucleoside diphosphate kinase 6 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC163619
      UniProtKB/Swiss-Prot
      O88425, Q99M53

    2. NM_001409695.1 → NP_001396624.1  nucleoside diphosphate kinase 6 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC163619
      UniProtKB/Swiss-Prot
      O88425, Q99M53
      Related
      ENSMUSP00000142609.2, ENSMUST00000200005.5

    3. NM_001409696.1 → NP_001396625.1  nucleoside diphosphate kinase 6 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC163619
      UniProtKB/Swiss-Prot
      O88425, Q99M53

    4. NM_001409698.1 → NP_001396627.1  nucleoside diphosphate kinase 6 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC163619
      UniProtKB/Swiss-Prot
      O88425, Q99M53
      Related
      ENSMUSP00000143021.2, ENSMUST00000200468.2

    5. NM_001409699.1 → NP_001396628.1  nucleoside diphosphate kinase 6 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC163619

    6. NM_001409700.1 → NP_001396629.1  nucleoside diphosphate kinase 6 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC163619
      Related
      ENSMUST00000196797.5

    7. NM_001409701.1 → NP_001396630.1  nucleoside diphosphate kinase 6 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC163619
      Related
      ENSMUST00000198201.5

    8. NM_001409702.1 → NP_001396631.1  nucleoside diphosphate kinase 6 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC163619

    9. NM_001409703.1 → NP_001396632.1  nucleoside diphosphate kinase 6 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC163619
      UniProtKB/TrEMBL
      A0A0G2JEH8
      Related
      ENSMUSP00000142778.2, ENSMUST00000197627.5

    10. NM_018757.2 → NP_061227.1  nucleoside diphosphate kinase 6 isoform 1

      See identical proteins and their annotated locations for NP_061227.1

      Status: VALIDATED

      Source sequence(s)
      AC163619
      Consensus CDS
      CCDS23558.1
      UniProtKB/Swiss-Prot
      O88425, Q99M53
      UniProtKB/TrEMBL
      A0A0G2JE30
      Related
      ENSMUSP00000035053.6, ENSMUST00000035053.12
      Conserved Domains (1) summary
      cd04414
      Location:12 → 146
      NDPk6; Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has ...

    RNA

    1. NR_176891.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC163619

    2. NR_176892.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC163619

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      109661830..109672042
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512199.4 → XP_006512262.1  nucleoside diphosphate kinase 6 isoform X1

      See identical proteins and their annotated locations for XP_006512262.1

      UniProtKB/Swiss-Prot
      O88425, Q99M53
      UniProtKB/TrEMBL
      A0A0G2JE30
      Conserved Domains (1) summary
      cd04414
      Location:12 → 146
      NDPk6; Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88425.1 GenPept UniProtKB/Swiss-Prot:O88425

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