Nptn neuroplastin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nptnprovided by MGI
Official Full Name: neuroplastinprovided by MGI
Primary source: MGI:MGI:108077
See related: Ensembl:ENSMUSG00000032336 AllianceGenome:MGI:108077
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NP65; SDR-1; Sdfr1
Summary: Predicted to enable cell-cell adhesion mediator activity; transmembrane transporter binding activity; and type 1 fibroblast growth factor receptor binding activity. Involved in cellular calcium ion homeostasis and negative regulation of cytokine production. Acts upstream of or within excitatory synapse assembly; modulation of chemical synaptic transmission; and regulation of receptor localization to synapse. Located in dendrite and immunological synapse. Is expressed in several structures, including cardiovascular system; genitourinary system; gut; nervous system; and respiratory system. Orthologous to human NPTN (neuroplastin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in cortex adult (RPKM 131.7), cerebellum adult (RPKM 131.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 B; 9 31.79 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (58489504..58560162)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (58582240..58652879)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neuroplastin Expression in Male Mice Is Essential for Fertility, Mating, and Adult Testosterone Levels.
Title: Neuroplastin Expression in Male Mice Is Essential for Fertility, Mating, and Adult Testosterone Levels.
The role of neuroplastin65 in macrophage against E. coli infection in mice.
Title: The role of neuroplastin65 in macrophage against E. coli infection in mice.
Neuroplastin genetically interacts with Cadherin 23 and the encoded isoform Np55 is sufficient for cochlear hair cell function and hearing.
Title: Neuroplastin genetically interacts with Cadherin 23 and the encoded isoform Np55 is sufficient for cochlear hair cell function and hearing.
Plasma Membrane Calcium ATPase-Neuroplastin Complexes Are Selectively Stabilized in GM1-Containing Lipid Rafts.
Title: Plasma Membrane Calcium ATPase-Neuroplastin Complexes Are Selectively Stabilized in GM1-Containing Lipid Rafts.
The amino-terminal domain of GluA1 mediates LTP maintenance via interaction with neuroplastin-65.
Title: The amino-terminal domain of GluA1 mediates LTP maintenance via interaction with neuroplastin-65.
Np65 KO mice display display enhanced anxiety-like behavior, a reduction in some aspects of depressive-like behaviors, and increased sociability and memory. Np65 KO mice show increased neurons proliferation, reduced 5-HT level and impaired long-term potentiation in the hippocampus.
Title: Neuroplastin 65 modulates anxiety- and depression-like behavior likely through adult hippocampal neurogenesis and central 5-HT activity.
these results indicate that epilation induces McSCs activation through EDN3/EDNRB signaling and in turn leads to skin and hair hyperpigmentation. The findings suggest that EDN/EDNRB signaling may serve as a potential therapeutic target to promote repigmentation in hypopigmentation disorders.
Title: Neuroplastin deletion in glutamatergic neurons impairs selective brain functions and calcium regulation: implication for cognitive deterioration.
findings suggest that ablation of Np65 influences gene expression, which may contribute to abnormal brain development; these results provide clues to the mechanisms underlying the altered brain functions of Np65-deficient mice
Title: Microarray Analysis of Gene Expression Changes in Neuroplastin 65-Knockout Mice: Implications for Abnormal Cognition and Emotional Disorders.
results establish neuroplastin and basigin as obligatory auxiliary subunits of native Plasma Membrane Calcium Atpases and key regulators of intracellular Ca2+ concentration.
Title: Neuroplastin and Basigin Are Essential Auxiliary Subunits of Plasma Membrane Ca(2+)-ATPases and Key Regulators of Ca(2+) Clearance.
The current study shows that neuroplastin, a member of the Ig superfamily, which has previously been linked to the regulation of synaptic plasticity, is critical to maintain a stable mechanical link of outer hair cells with the tectorial membrane.
Title: Neuroplastin Isoform Np55 Is Expressed in the Stereocilia of Outer Hair Cells and Required for Normal Outer Hair Cell Function.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (6) 1 citation
Chemically induced (ENU) (2) 1 citation
Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_21804-21805:1025095690:1 (e-PCR)
- UniSTS:268634

UniSTS:236151 (e-PCR)
- UniSTS:236151

AW554172 (e-PCR)
- UniSTS:179920

47.MMHAP30FLH5.seq (e-PCR)
- UniSTS:124650

RH126347 (e-PCR)
- UniSTS:163055

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cell adhesion molecule binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info
enables type 1 fibroblast growth factor receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within excitatory synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	ISO Inferred from Sequence Orthology more info
involved_in intracellular calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of long-term neuronal synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of receptor localization to synapse	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within synapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in visual learning	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in immunological synapse	IDA Inferred from Direct Assay more info	PubMed
located_in inhibitory synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic active zone membrane	ISO Inferred from Sequence Orthology more info
located_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info
is_active_in synaptic membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: neuroplastin

Names: stromal cell derived factor receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001293673.2 → NP_001280602.1 neuroplastin isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 3. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 3.

Source sequence(s)

CT030640

Consensus CDS

CCDS81009.1

UniProtKB/TrEMBL

Z4YLB7

Related

ENSMUSP00000135541.2, ENSMUST00000176557.8

Conserved Domains (1) summary

cl11960
Location:133 → 216

Ig; Immunoglobulin domain
NM_001357751.2 → NP_001344680.1 neuroplastin isoform 3 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).

Source sequence(s)

CT030640

Conserved Domains (2) summary

cd00096
Location:48 → 121

Ig; Immunoglobulin domain

cl11960
Location:249 → 332

Ig; Immunoglobulin domain
NM_001406062.1 → NP_001392991.1 neuroplastin isoform 4 precursor

Status: VALIDATED

Source sequence(s)

CT030640

UniProtKB/Swiss-Prot

P97300, Q3U519, Q8C637, Q8C6H8
NM_009145.3 → NP_033171.2 neuroplastin isoform 1 precursor

See identical proteins and their annotated locations for NP_033171.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) lacks an alternate in-frame exon and uses an alternate in-frame splice junction compared to variant 3. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 3.

Source sequence(s)

CT030640

Consensus CDS

CCDS23245.1

UniProtKB/TrEMBL

Z4YLB7

Related

ENSMUSP00000082793.6, ENSMUST00000085651.12

Conserved Domains (1) summary

cl11960
Location:133 → 216

Ig; Immunoglobulin domain

RNA

NR_151824.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks an alternate exon and uses two alternate splice junctions compared to variant 3. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

CT030640

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

58489504..58560162

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006510883.3 → XP_006510946.1 neuroplastin isoform X1

See identical proteins and their annotated locations for XP_006510946.1

UniProtKB/Swiss-Prot

P97300, Q3U519, Q8C637, Q8C6H8

Related

ENSMUSP00000135199.2, ENSMUST00000177292.8

Conserved Domains (2) summary

cd00096
Location:48 → 121

Ig; Immunoglobulin domain

cl11960
Location:249 → 332

Ig; Immunoglobulin domain
XM_036154741.1 → XP_036010634.1 neuroplastin isoform X4

Conserved Domains (2) summary

cd00096
Location:32 → 36

Ig; Ig strand A [structural motif]

cl11960
Location:31 → 146

Ig; Immunoglobulin domain
XM_036154739.1 → XP_036010632.1 neuroplastin isoform X2

Conserved Domains (2) summary

cd00096
Location:32 → 36

Ig; Ig strand A [structural motif]

cl11960
Location:31 → 146

Ig; Immunoglobulin domain
XM_036154740.1 → XP_036010633.1 neuroplastin isoform X3

Conserved Domains (2) summary

cd00096
Location:32 → 36

Ig; Ig strand A [structural motif]

cl11960
Location:31 → 146

Ig; Immunoglobulin domain
XM_030244148.2 → XP_030100008.1 neuroplastin isoform X5

UniProtKB/TrEMBL

Z4YLB7

Conserved Domains (1) summary

cl11960
Location:133 → 216

Ig; Immunoglobulin domain