Stra6 stimulated by retinoic acid gene 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Stra6provided by MGI
Official Full Name: stimulated by retinoic acid gene 6provided by MGI
Primary source: MGI:MGI:107742
See related: Ensembl:ENSMUSG00000032327 AllianceGenome:MGI:107742
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable retinol transmembrane transporter activity. Acts upstream of or within positive regulation of receptor signaling pathway via JAK-STAT and retinol transport. Located in plasma membrane. Is expressed in several structures, including central nervous system; embryo mesenchyme; extraembryonic component; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in syndromic microphthalmia 9. Orthologous to human STRA6 (signaling receptor and transporter of retinol STRA6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in ovary adult (RPKM 12.1), subcutaneous fat pad adult (RPKM 11.6) and 17 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 9 B; 9 31.63 cM

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (57971076..58061287)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (58063793..58154004)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Unraveling the mystery of ocular retinoid turnover: Insights from albino mice and the role of STRA6.
Title: Unraveling the mystery of ocular retinoid turnover: Insights from albino mice and the role of STRA6.
STRA6 Promotes Thyroid Carcinoma Progression via Activation of the ILK/AKT/mTOR Axis in Cells and Female Nude Mice.
Title: STRA6 Promotes Thyroid Carcinoma Progression via Activation of the ILK/AKT/mTOR Axis in Cells and Female Nude Mice.
This study first indicates that STRA6-retinol signals were directly disrupted by O-GlcNAcylation in diabetic kidney.
Title: O-GlcNAcylation disrupts STRA6-retinol signals in kidneys of diabetes.
The STRA6 is potent regulators of diurnal insulin responses and suggest that the holo-RBP/STRA6 signaling axis may represent a novel therapeutic target in type II diabetes.
Title: The retinol-binding protein receptor STRA6 regulates diurnal insulin responses.
Suppression of STRA6 cascades is involved in renal apoptosis and fibrosis caused by electronegative low density lipoproteins.
Title: Electronegative low density lipoprotein induces renal apoptosis and fibrosis: STRA6 signaling involved.
These results showed that STRA6 is critical for vitamin A homeostasis and the adaption of this process to the fluctuating supply of the vitamin.-
Title: Transport of vitamin A across blood-tissue barriers is facilitated by STRA6.
Studies indicate that STRA6 is indeed a bona fide vitamin A transporter and provide novel insights into the regulatory mechanism that governs vitamin A homeostasis in peripheral tissues.
Title: STRA6 is critical for cellular vitamin A uptake and homeostasis.
Total vitamin A levels are dramatically lower in the eyes of STRA6 KO mice as compared to those of WT mice, but the levels in other organs were not significantly affected after STRA6 deletion under vitamin A sufficient conditions.
Title: To investigate the necessity of STRA6 upregulation in T cells during T cell immune responses.
STRA6 reduction in adipocytes in adipose-Stra6(-/-) mice.
Title: Downregulation of STRA6 in adipocytes and adipose stromovascular fraction in obesity and effects of adipocyte-specific STRA6 knockdown in vivo.
Rbp4 and its membrane receptor STRA6 control adipogenesis by regulating cellular retinoid homeostasis and RARalpha activity.
Title: Retinol-binding protein 4 and its membrane receptor STRA6 control adipogenesis by regulating cellular retinoid homeostasis and retinoic acid receptor α activity.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation
Targeted (5) 1 citation
Endonuclease-mediated (4)

General gene information

Go to the top of the page Help

Markers

AI891933 (e-PCR)
- UniSTS:165637

Stra6 (e-PCR), detects polymorphism
- UniSTS:498410

Stra6 (e-PCR), detects polymorphism
- UniSTS:516093

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables retinal binding	IEA Inferred from Electronic Annotation more info
enables retinol binding	IEA Inferred from Electronic Annotation more info
enables retinol transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adrenal gland development	ISO Inferred from Sequence Orthology more info
involved_in alveolar primary septum development	ISO Inferred from Sequence Orthology more info
involved_in artery morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in blood vessel development	ISO Inferred from Sequence Orthology more info
involved_in camera-type eye development	ISO Inferred from Sequence Orthology more info
involved_in cognition	ISO Inferred from Sequence Orthology more info
involved_in developmental growth	ISO Inferred from Sequence Orthology more info
involved_in diaphragm development	ISO Inferred from Sequence Orthology more info
involved_in digestive tract morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in ductus arteriosus closure	ISO Inferred from Sequence Orthology more info
involved_in ear development	ISO Inferred from Sequence Orthology more info
involved_in embryonic camera-type eye formation	ISO Inferred from Sequence Orthology more info
involved_in embryonic digestive tract development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eyelid development in camera-type eye	ISO Inferred from Sequence Orthology more info
involved_in face morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in feeding behavior	ISO Inferred from Sequence Orthology more info
involved_in female genitalia development	ISO Inferred from Sequence Orthology more info
involved_in head development	ISO Inferred from Sequence Orthology more info
involved_in head morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in heart development	ISO Inferred from Sequence Orthology more info
involved_in kidney development	ISO Inferred from Sequence Orthology more info
involved_in learning	ISO Inferred from Sequence Orthology more info
involved_in lung alveolus development	ISO Inferred from Sequence Orthology more info
involved_in lung development	ISO Inferred from Sequence Orthology more info
involved_in lung vasculature development	ISO Inferred from Sequence Orthology more info
involved_in neuromuscular process	ISO Inferred from Sequence Orthology more info
involved_in nose morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in paramesonephric duct development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of receptor signaling pathway via JAK-STAT	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pulmonary artery morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in pulmonary valve morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retinol transport	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within retinol transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retinol transport	ISO Inferred from Sequence Orthology more info
involved_in smooth muscle tissue development	ISO Inferred from Sequence Orthology more info
involved_in uterus morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in ventricular septum development	ISO Inferred from Sequence Orthology more info
involved_in vitamin A import into cell	IBA Inferred from Biological aspect of Ancestor more info
involved_in vocal learning	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: receptor for retinol uptake STRA6

Names: retinoic acid-responsive protein; retinol-binding protein receptor STRA6; stimulated by retinoic acid gene 6 protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001162475.1 → NP_001155947.1 receptor for retinol uptake STRA6

See identical proteins and their annotated locations for NP_001155947.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.

Source sequence(s)

BC075657, CO043377

Consensus CDS

CCDS23236.1

UniProtKB/Swiss-Prot

O70491, Q6DIA8

UniProtKB/TrEMBL

A0A0R4J115

Related

ENSMUSP00000082820.3, ENSMUST00000085677.9

Conserved Domains (1) summary

pfam14752
Location:41 → 657

RBP_receptor; Retinol binding protein receptor
NM_001162476.1 → NP_001155948.1 receptor for retinol uptake STRA6

See identical proteins and their annotated locations for NP_001155948.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1-4 encode the same protein.

Source sequence(s)

AC158996, BC075657, CF536552, CO043377

Consensus CDS

CCDS23236.1

UniProtKB/Swiss-Prot

O70491, Q6DIA8

UniProtKB/TrEMBL

A0A0R4J115

Related

ENSMUSP00000130232.2, ENSMUST00000170397.8

Conserved Domains (1) summary

pfam14752
Location:41 → 657

RBP_receptor; Retinol binding protein receptor
NM_001162479.1 → NP_001155951.1 receptor for retinol uptake STRA6

See identical proteins and their annotated locations for NP_001155951.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.

Source sequence(s)

BC075657, CF742607, CO043377

Consensus CDS

CCDS23236.1

UniProtKB/Swiss-Prot

O70491, Q6DIA8

UniProtKB/TrEMBL

A0A0R4J115

Related

ENSMUSP00000128417.2, ENSMUST00000167479.8

Conserved Domains (1) summary

pfam14752
Location:41 → 657

RBP_receptor; Retinol binding protein receptor
NM_009291.2 → NP_033317.2 receptor for retinol uptake STRA6

See identical proteins and their annotated locations for NP_033317.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.

Source sequence(s)

AC158996, BC075657, CF730004, CF735552, CO043377, CX237908

Consensus CDS

CCDS23236.1

UniProtKB/Swiss-Prot

O70491, Q6DIA8

UniProtKB/TrEMBL

A0A0R4J115

Related

ENSMUSP00000034880.4, ENSMUST00000034880.10

Conserved Domains (1) summary

pfam14752
Location:41 → 657

RBP_receptor; Retinol binding protein receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

57971076..58061287

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006510941.3 → XP_006511004.2 receptor for retinol uptake STRA6 isoform X1

See identical proteins and their annotated locations for XP_006511004.2

UniProtKB/Swiss-Prot

O70491, Q6DIA8

UniProtKB/TrEMBL

A0A0R4J115

Conserved Domains (1) summary

pfam14752
Location:41 → 657

RBP_receptor; Retinol binding protein receptor
XM_036154773.1 → XP_036010666.1 receptor for retinol uptake STRA6 isoform X3

Conserved Domains (1) summary

pfam14752
Location:41 → 434

RBP_receptor; Retinol binding protein receptor
XM_017313262.1 → XP_017168751.1 receptor for retinol uptake STRA6 isoform X2

UniProtKB/Swiss-Prot

O70491, Q6DIA8

Conserved Domains (1) summary

pfam14752
Location:74 → 690

RBP_receptor; Retinol binding protein receptor
XM_006510945.5 → XP_006511008.1 receptor for retinol uptake STRA6 isoform X1

See identical proteins and their annotated locations for XP_006511008.1

UniProtKB/Swiss-Prot

O70491, Q6DIA8

UniProtKB/TrEMBL

A0A0R4J115

Conserved Domains (1) summary

pfam14752
Location:41 → 657

RBP_receptor; Retinol binding protein receptor
XM_006510943.3 → XP_006511006.1 receptor for retinol uptake STRA6 isoform X1

See identical proteins and their annotated locations for XP_006511006.1

UniProtKB/Swiss-Prot

O70491, Q6DIA8

UniProtKB/TrEMBL

A0A0R4J115

Conserved Domains (1) summary

pfam14752
Location:41 → 657

RBP_receptor; Retinol binding protein receptor
XM_006510944.4 → XP_006511007.1 receptor for retinol uptake STRA6 isoform X1

See identical proteins and their annotated locations for XP_006511007.1

UniProtKB/Swiss-Prot

O70491, Q6DIA8

UniProtKB/TrEMBL

A0A0R4J115

Conserved Domains (1) summary

pfam14752
Location:41 → 657

RBP_receptor; Retinol binding protein receptor
XM_030244180.2 → XP_030100040.1 receptor for retinol uptake STRA6 isoform X1

UniProtKB/Swiss-Prot

O70491, Q6DIA8

UniProtKB/TrEMBL

A0A0R4J115

Conserved Domains (1) summary

pfam14752
Location:41 → 657

RBP_receptor; Retinol binding protein receptor
XM_006510946.3 → XP_006511009.1 receptor for retinol uptake STRA6 isoform X1

See identical proteins and their annotated locations for XP_006511009.1

UniProtKB/Swiss-Prot

O70491, Q6DIA8

UniProtKB/TrEMBL

A0A0R4J115

Conserved Domains (1) summary

pfam14752
Location:41 → 657

RBP_receptor; Retinol binding protein receptor