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    Polr2m polymerase (RNA) II (DNA directed) polypeptide M [ Mus musculus (house mouse) ]

    Gene ID: 28015, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Polr2mprovided by MGI
    Official Full Name
    polymerase (RNA) II (DNA directed) polypeptide Mprovided by MGI
    Primary source
    MGI:MGI:107282
    See related
    Ensembl:ENSMUSG00000032199 AllianceGenome:MGI:107282
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Grinl1a; D9Wsu138e; mKIAA4185
    Summary
    Predicted to enable DNA-directed 5'-3' RNA polymerase activity. Involved in maintenance of ER location. Located in neuronal cell body. Is expressed in brain; extraembryonic component; and genitourinary system. Orthologous to several human genes including GCOM1 (GCOM1, MYZAP-POLR2M combined locus). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 79.8), limb E14.5 (RPKM 68.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 D; 9 39.85 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (71385719..71393265, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (71478437..71485983, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24569 Neighboring gene aldehyde dehydrogenase family 1, subfamily A2 Neighboring gene STARR-seq mESC enhancer starr_24571 Neighboring gene predicted gene, 32769 Neighboring gene STARR-seq mESC enhancer starr_24572 Neighboring gene STARR-seq mESC enhancer starr_24574 Neighboring gene myocardial zonula adherens protein Neighboring gene STARR-seq mESC enhancer starr_24575 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:71418063-71418246 Neighboring gene MAD1 mitotic arrest deficient 1-like 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The mouse orthologue of the human ionotropic glutamate receptor-like gene (GRINL1A) maps(1) to mouse chromosome 9. Wydner KS, et al. Cytogenet Cell Genet, 2001. PMID 12063408
    2. The tumor suppressor MIR139 is silenced by POLR2M to promote AML oncogenesis. Stavast CJ, et al. Leukemia, 2022 Mar. PMID 34741119, Free PMC Article
    3. Transcriptional down-regulation of metabolic genes by Gdown1 ablation induces quiescent cell re-entry into the cell cycle. Jishage M, et al. Genes Dev, 2020 Jun 1. PMID 32381628, Free PMC Article
    4. Specific assembly with the NMDA receptor 3B subunit controls surface expression and calcium permeability of NMDA receptors. Matsuda K, et al. J Neurosci, 2003 Nov 5. PMID 14602821, Free PMC Article
    5. Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Ko MS, et al. Hum Mol Genet, 1998 Nov. PMID 9811942

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The tumor suppressor MIR139 is silenced by POLR2M to promote AML oncogenesis.
      Title: The tumor suppressor MIR139 is silenced by POLR2M to promote AML oncogenesis.
    2. Transcriptional down-regulation of metabolic genes by Gdown1 ablation induces quiescent cell re-entry into the cell cycle.
      Title: Transcriptional down-regulation of metabolic genes by Gdown1 ablation induces quiescent cell re-entry into the cell cycle.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA4185

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA polymerase II complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables transcription elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maintenance of ER location IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maintenance of ER location IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription elongation by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of DNA-directed RNA polymerase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in I band IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase II, core complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of RNA polymerase II, holoenzyme IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in intracellular anatomical structure IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuronal cell body IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription preinitiation complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DNA-directed RNA polymerase II subunit GRINL1A
    Names
    DNA-directed RNA polymerase II subunit M
    glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A
    glutamate receptor-like protein 1A
    protein GRINL1A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164793.1 → NP_001158265.1  DNA-directed RNA polymerase II subunit GRINL1A isoform 2

      See identical proteins and their annotated locations for NP_001158265.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AK002571, BE993895
      Consensus CDS
      CCDS52853.1
      UniProtKB/Swiss-Prot
      Q6P6I6
      Related
      ENSMUSP00000132335.2, ENSMUST00000163972.2
      Conserved Domains (1) summary
      pfam15328
      Location:1 → 135
      GCOM2; Putative GRINL1B complex locus protein 2

    2. NM_178602.3 → NP_848717.1  DNA-directed RNA polymerase II subunit GRINL1A isoform 1

      See identical proteins and their annotated locations for NP_848717.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK052037, BE993895, BQ443340
      Consensus CDS
      CCDS23326.1
      UniProtKB/Swiss-Prot
      Q6P6I6, Q8CG13, Q9CXJ7, Q9DCQ9
      Related
      ENSMUSP00000034720.6, ENSMUST00000034720.12
      Conserved Domains (1) summary
      pfam15328
      Location:37 → 239
      GCOM2; Putative GRINL1B complex locus protein 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      71385719..71393265 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P6I6.2 GenPept UniProtKB/Swiss-Prot:Q6P6I6

    Gene LinkOut

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