Dctn6 dynactin 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dctn6provided by MGI
Official Full Name: dynactin 6provided by MGI
Primary source: MGI:MGI:1343154
See related: Ensembl:ENSMUSG00000031516 AllianceGenome:MGI:1343154
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p27; WS-3
Summary: Enables dynein complex binding activity. Acts upstream of or within mitotic spindle organization. Part of dynactin complex. Is expressed in embryo; extraembryonic component; oocyte; primitive endoderm; and yolk sac. Orthologous to human DCTN6 (dynactin subunit 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in bladder adult (RPKM 26.7), CNS E14 (RPKM 22.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 A4; 8 20.9 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (34557574..34575866, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (34090420..34108712, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dynactin 6 deficiency enhances aging-associated dystrophic neurite formation in mouse brains.
Title: Dynactin 6 deficiency enhances aging-associated dystrophic neurite formation in mouse brains.
Dynactin helps target Polo-like kinase 1 to kinetochores via its left-handed beta-helical p27 subunit.
Title: Dynactin helps target Polo-like kinase 1 to kinetochores via its left-handed beta-helical p27 subunit.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU044699 (e-PCR)
- UniSTS:159752

D19214 (e-PCR)
- UniSTS:124792

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables catalytic activity	NAS Non-traceable Author Statement more info	PubMed
enables dynein complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in lipid biosynthetic process	NAS Non-traceable Author Statement more info	PubMed
involved_in mitochondrion organization	NAS Non-traceable Author Statement more info	PubMed
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mitotic spindle organization	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
part_of dynactin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of dynactin complex	IDA Inferred from Direct Assay more info	PubMed
located_in kinetochore	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: dynactin subunit 6

Names: RGD containing protein; dynactin subunit p27; p27 dynactin subunit; protein WS-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001293757.1 → NP_001280686.1 dynactin subunit 6 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AK003618, BU756370, CA573939, DV062065

Consensus CDS

CCDS80870.1

UniProtKB/TrEMBL

D3Z4E5

Related

ENSMUSP00000113716.2, ENSMUST00000117243.8

Conserved Domains (1) summary

cd04646
Location:36 → 184

LbH_Dynactin_6; Dynactin 6 (or subunit p27): Dynactin is a major component of the activator complex that stimulates dynein-mediated vesicle transport. Dynactin is a heterocomplex of at least eight subunits, including a 150,000-MW protein called Glued, the actin-capping ...
NM_001293758.1 → NP_001280687.1 dynactin subunit 6 isoform 3

See identical proteins and their annotated locations for NP_001280687.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate internal exon and has an alternate first exon compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

AK003618, BU756370, CA579919, DV042569

Consensus CDS

CCDS80871.1

UniProtKB/TrEMBL

D3Z6H3

Related

ENSMUSP00000113280.2, ENSMUST00000118811.8

Conserved Domains (1) summary

cd04646
Location:5 → 174

LbH_Dynactin_6; Dynactin 6 (or subunit p27): Dynactin is a major component of the activator complex that stimulates dynein-mediated vesicle transport. Dynactin is a heterocomplex of at least eight subunits, including a 150,000-MW protein called Glued, the actin-capping ...
NM_001293759.1 → NP_001280688.1 dynactin subunit 6 isoform 4

See identical proteins and their annotated locations for NP_001280688.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks an alternate exon and contains another alternate exon compared to variant 1. The resulting isoform (4) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AK003618, BU756370, CA573939, CV560309

UniProtKB/Swiss-Prot

Q9WUB4

Conserved Domains (1) summary

cd04646
Location:1 → 98

LbH_Dynactin_6; Dynactin 6 (or subunit p27): Dynactin is a major component of the activator complex that stimulates dynein-mediated vesicle transport. Dynactin is a heterocomplex of at least eight subunits, including a 150,000-MW protein called Glued, the actin-capping ...
NM_011722.4 → NP_035852.1 dynactin subunit 6 isoform 2

See identical proteins and their annotated locations for NP_035852.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

AK003618, BU756370, CA573939

Consensus CDS

CCDS22238.1

UniProtKB/Swiss-Prot

Q8C2M9, Q9QZB8, Q9WUB4

Related

ENSMUSP00000033913.5, ENSMUST00000033913.11

Conserved Domains (1) summary

cd04646
Location:10 → 179

LbH_Dynactin_6; Dynactin 6 (or subunit p27): Dynactin is a major component of the activator complex that stimulates dynein-mediated vesicle transport. Dynactin is a heterocomplex of at least eight subunits, including a 150,000-MW protein called Glued, the actin-capping ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

34557574..34575866 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006509094.3 → XP_006509157.1 dynactin subunit 6 isoform X1

Conserved Domains (1) summary

cd04646
Location:10 → 197

LbH_Dynactin_6; Dynactin 6 (or subunit p27): Dynactin is a major component of the activator complex that stimulates dynein-mediated vesicle transport. Dynactin is a heterocomplex of at least eight subunits, including a 150,000-MW protein called Glued, the actin-capping ...
XM_030243416.2 → XP_030099276.1 dynactin subunit 6 isoform X3

Conserved Domains (1) summary

cd04646
Location:18 → 166

LbH_Dynactin_6; Dynactin 6 (or subunit p27): Dynactin is a major component of the activator complex that stimulates dynein-mediated vesicle transport. Dynactin is a heterocomplex of at least eight subunits, including a 150,000-MW protein called Glued, the actin-capping ...
XM_036153882.1 → XP_036009775.1 dynactin subunit 6 isoform X4

Conserved Domains (1) summary

cd04646
Location:1 → 98

LbH_Dynactin_6; Dynactin 6 (or subunit p27): Dynactin is a major component of the activator complex that stimulates dynein-mediated vesicle transport. Dynactin is a heterocomplex of at least eight subunits, including a 150,000-MW protein called Glued, the actin-capping ...
XM_036153881.1 → XP_036009774.1 dynactin subunit 6 isoform X2

Conserved Domains (1) summary

cd04646
Location:5 → 192

LbH_Dynactin_6; Dynactin 6 (or subunit p27): Dynactin is a major component of the activator complex that stimulates dynein-mediated vesicle transport. Dynactin is a heterocomplex of at least eight subunits, including a 150,000-MW protein called Glued, the actin-capping ...
XM_030243417.2 → XP_030099277.1 dynactin subunit 6 isoform X4

Conserved Domains (1) summary

cd04646
Location:1 → 98

LbH_Dynactin_6; Dynactin 6 (or subunit p27): Dynactin is a major component of the activator complex that stimulates dynein-mediated vesicle transport. Dynactin is a heterocomplex of at least eight subunits, including a 150,000-MW protein called Glued, the actin-capping ...