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    Rasa3 RAS p21 protein activator 3 [ Mus musculus (house mouse) ]

    Gene ID: 19414, updated on 11-Apr-2024

    Summary

    Official Symbol
    Rasa3provided by MGI
    Official Full Name
    RAS p21 protein activator 3provided by MGI
    Primary source
    MGI:MGI:1197013
    See related
    Ensembl:ENSMUSG00000031453 AllianceGenome:MGI:1197013
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    scat; GAPIII; hlb381; E130011G04
    Summary
    Predicted to enable calcium-release channel activity. Predicted to be involved in intracellular signal transduction; negative regulation of Ras protein signal transduction; and regulation of GTPase activity. Predicted to act upstream of or within cellular response to heat. Predicted to be intrinsic component of the cytoplasmic side of the plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and neural retina. Used to study aplastic anemia. Orthologous to human RASA3 (RAS p21 protein activator 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in spleen adult (RPKM 50.1), mammary gland adult (RPKM 30.6) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Rasa3 in Genome Data Viewer
    Location:
    8 A1.1; 8 6.29 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (13617218..13727590, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (13567218..13677587, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 255B Neighboring gene growth arrest specific 6 Neighboring gene predicted gene, 53399 Neighboring gene RIKEN cDNA 1700029H14 gene Neighboring gene STARR-seq mESC enhancer starr_20769 Neighboring gene STARR-seq mESC enhancer starr_20770 Neighboring gene STARR-positive B cell enhancer ABC_E2857 Neighboring gene predicted gene, 34795 Neighboring gene VISTA enhancer mm1751 Neighboring gene STARR-positive B cell enhancer ABC_E10490 Neighboring gene predicted gene, 46032 Neighboring gene STARR-seq mESC enhancer starr_20774 Neighboring gene STARR-seq mESC enhancer starr_20775 Neighboring gene CFAP97 domain containing 2 Neighboring gene 3-phosphoglycerate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    severe combined anemia and thrombocytopenia
    GeneReviews: Not available

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Spontaneous (1)  1 citation
    • Targeted (8)  1 citation
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables intracellularly gated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to heat ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ras GTPase-activating protein 3
    Names
    GAP1(IP4BP)
    GAPIII activator 3
    R-Ras gap
    R-ras RTPase activating protein-3
    Ras GTPase-activating protein III
    ins P4-binding protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009025.2NP_033051.2  ras GTPase-activating protein 3

      See identical proteins and their annotated locations for NP_033051.2

      Status: VALIDATED

      Source sequence(s)
      BC057300, CA749631
      Consensus CDS
      CCDS40234.1
      UniProtKB/Swiss-Prot
      Q60790, Q6PG24, Q925V1
      UniProtKB/TrEMBL
      Q3UGJ5
      Related
      ENSMUSP00000112998.3, ENSMUST00000117551.4
      Conserved Domains (7) summary
      smart00107
      Location:679714
      BTK; Bruton's tyrosine kinase Cys-rich motif
      cd04010
      Location:146288
      C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
      cd08401
      Location:13133
      C2A_RasA2_RasA3; C2 domain first repeat present in RasA2 and RasA3
      cd05134
      Location:297565
      RasGAP_RASA3; Ras-GTPase Activating Domain of RASA3
      smart00323
      Location:275614
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd13371
      Location:562686
      PH_GAP1_mammal-like; GAP1(IP4BP) pleckstrin homology (PH) domain
      pfam00169
      Location:577676
      PH; PH domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      13617218..13727590 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508734.3XP_006508797.1  ras GTPase-activating protein 3 isoform X1

      UniProtKB/TrEMBL
      Q3UGJ5
      Conserved Domains (5) summary
      smart00107
      Location:647682
      BTK; Bruton's tyrosine kinase Cys-rich motif
      cd04010
      Location:114256
      C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
      cd08401
      Location:1101
      C2A_RasA2_RasA3; C2 domain first repeat present in RasA2 and RasA3
      cd05134
      Location:265533
      RasGAP_RASA3; Ras-GTPase Activating Domain of RASA3
      cd13371
      Location:530654
      PH_GAP1_mammal-like; GAP1(IP4BP) pleckstrin homology (PH) domain